Patents by Inventor Maria Moreno

Maria Moreno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250057981
    Abstract: Described herein are epigenetic modulators that modulate expression of voltage gated sodium channels, such as Nav1.7 and Nav1.8, without editing the genetic sequence. An epigenetic modulator may include a nucleic acid-binding agent that binds to a target sequence within a gene encoding the voltage gated sodium channel and an expression modulating agent that modulates expression of the gene. Also described herein are methods of treating inflammation, pain, or both using an epigenetic modulator of Nav1.7 or Nav1.8.
    Type: Application
    Filed: June 25, 2024
    Publication date: February 20, 2025
    Inventors: Ana Maria MORENO COLLADO, Fernando ALEMAN GUILLEN
  • Publication number: 20250057960
    Abstract: The present disclosure provides complexes comprising: i) a cationic oligosaccharide comprising one or more cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6; ii) a surfactant; and iii) one or more additives selected from: a sterol, a helper lipid, an immunomodulator, and a targeting molecule; and uses thereof.
    Type: Application
    Filed: October 21, 2022
    Publication date: February 20, 2025
    Inventors: Jorge Moreno Herrero, Heinrich Haas, Stephanie Erbar, Theo Benjamin Stahl, José Manuel García Fernández, Juan Manuel Benito Hernández, Jose Lopez Fernandez, Maria del Carmen Ortiz Mellet, Noelia de la Cruz Ruiz, Manuel González Cuesta, Egon Jack Jacobus Ambuludi, Irena Vlatkovic
  • Publication number: 20250055764
    Abstract: A method (200) is disclosed for orchestrating management of a plurality of operational parameters in an environment of a communication network. Each of the operational parameters is managed by a respective Agent, and at least one performance parameter of the communication network is operable to be impacted by each of the operational parameters. The method comprises obtaining a representation of a state of the environment (210), and generating a prediction, using an ML process and the obtained state representation, of which of the Agents, if allowed to execute within the environment an action selected by the Agent for management of its operational parameter, will result in the greatest increase of a performance measure for the communication network (220). The method further comprises selecting an Agent on the basis of the prediction (230) and initiating execution by the selected Agent of its selected action (240).
    Type: Application
    Filed: May 20, 2022
    Publication date: February 13, 2025
    Inventors: Jose Outes Carnero, Adriano Mendo Mateo, Yak Ng Molina, Juan Ramiro Moreno, Jose Maria Ruiz Aviles, Paulo Antonio Moreira Mijares, Rakibul Islam Rony
  • Publication number: 20250031842
    Abstract: The invention relates to a workspace wall (1) for placement on a desk to reduce noise within a noise reduction area (7) in an operating orientation (11). The workspace wall (1) comprises a main wall element (3), at least one wing panel (4), optionally at least one sound detection element (21) for detecting a sound signal input (12), and at least one sound generating device (22), preferably for active noise reduction and/or a passive noise reduction element (20). The at least one sound generating device (22) and/or the passive noise reduction element (20) is configured to reduce the level of noise within the noise reduction area (7). (FIG.
    Type: Application
    Filed: November 24, 2022
    Publication date: January 30, 2025
    Applicant: WOAS SA
    Inventors: Julien LACOUR-GAYET, Marcel SCHLOTTERBECK, Blake Ramsay MCELDOWNEY, Jaime Tomas MORENO MEDINA, Diego GARCIA GARCÍA, Juan SORIANO BLANCO, Peter KUKORELLI, Alejandro ROQUERO MENDIOLA, Carlos FERNÁNDEZ DE TROCÓNIZ CRESPO, Mauricio Iván OCAMPO JORDÁN, Barbara GALA SAN ROMAN FUENTES, Ahmad AL ZUBAIDI, Wilhelmus Maria WAGENAARS, Analena VATER, Hervé LISSEK, Stanislav SERGEEV
  • Publication number: 20240408249
    Abstract: Compounds, e.g., radioimmunoconjuguates including a chelating moiety or a metal complex thereof, a linker, and an EGFRVIII targeting moiety. Pharmaceutical compositions of such compounds and methods of treatment for conditions. e.g., cancer, using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 29, 2022
    Publication date: December 12, 2024
    Inventors: Natalie Grinshtein, Julie Metcalf, Ian R. Duffy, William Leslie Turnbull, Anne Marcil, Maria Jaramillo, Traian Sulea, Maria Moreno, Cunle Wu
  • Publication number: 20240400697
    Abstract: Antigen-binding agents such as humanized antibodies or antigen-binding fragments thereof, that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRVIII-specific humanized antibodies or antigen-binding fragments thereof may be used for the treatment of cancer.
    Type: Application
    Filed: September 29, 2021
    Publication date: December 5, 2024
    Inventors: Anne MARCIL, Maria JARAMILLO, Traian SULEA, Maria MORENO, Cunle WU
  • Publication number: 20240366795
    Abstract: Described herein are compositions and methods to modulate gene expression without permanently editing the genome. The compositions and methods may be useful to treat neurological diseases and pain.
    Type: Application
    Filed: January 31, 2022
    Publication date: November 7, 2024
    Inventors: Fernando ALEMAN GUILLEN, Ana Maria MORENO COLLADO
  • Publication number: 20240309366
    Abstract: Provided herein are compositions and methods for treating metabolic disorders, such as hepatic steatosis, adipose tissue dysfunction, and insulin resistance. Small interfering RNAs (siRNAs) targeting LPS-binding protein (LBP) that include unlocked nucleotides (UNA) and their therapeutic applications for the treatment of metabolic disorders are provided herein.
    Type: Application
    Filed: December 30, 2021
    Publication date: September 19, 2024
    Inventors: Ramón Díaz TRELLES, Kiyoshi TACHIKAWA, Priya Prakash KARMALI, Rajesh MUKTHAVARAM, Padmanabh CHIVUKULA, José María MORENO-NAVARRETE, Aleix Gavaldá NAVARRO, José Manuel FERNÁNDEZ-REAL, Marta Giralt OMS, Francesc Villarroya GOMBAU
  • Patent number: 11945858
    Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: April 2, 2024
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Marzia Martina, Balu Chakravarthy, Yves Durocher, Mehdi Arbabi-Ghahroudi, Anne Marcil, Danica Stanimirovic, Traian Sulea, Maria Moreno, Umberto Banderali
  • Publication number: 20230270445
    Abstract: An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Applicant: MicroVention, Inc.
    Inventors: Jared Shimizu, Heath Bowman, Kiet Lam, Rohini Retarekar, Maria Moreno, Rogelio Cortez
  • Patent number: 11678888
    Abstract: An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.
    Type: Grant
    Filed: June 26, 2020
    Date of Patent: June 20, 2023
    Assignee: MicroVention, Inc.
    Inventors: Jared Shimizu, Heath Bowman, Kiet Lam, Rohini Retarekar, Maria Moreno, Rogelio Cortez
  • Publication number: 20220193132
    Abstract: Antigen-binding agents such as antibodies or antigen-binding fragments thereof, chimeric antigen receptors (CARs), bispecific T-cell engagers (BiTEs) and the like that specifically bind to epidermal growth factor receptor variant III (EGFRvIII) are provided. The EGFRvIII-specific antibodies or antigen-binding fragments, CARs and BiTEs thereof may be used for the treatment of cancer. Antibody drug conjugates targeting EGFRvIII-expressing cells are particularly contemplated.
    Type: Application
    Filed: March 23, 2020
    Publication date: June 23, 2022
    Inventors: Anne MARCIL, Maria JARAMILLO, Traian SULEA, Maria MORENO, Cunle WU
  • Patent number: 11225503
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: January 18, 2022
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • Publication number: 20210277410
    Abstract: The present invention pertains to genetically modified plants, particularly maize, sorghum and rice, with an all pistillate or all staminate phenotype and methods of the same. The survival of functional pistils in maize requires the action of the sk1 gene. SK1 encodes a glycosyltransferase (GT) that protects pistils from tasselseed-mediated cell death. sk1-dependent pistil protection at a developing floret gives rise to stamen arrest at the same floret, and so determines the pistillate floral fate. This is the first single gain-of-function gene known to control sexuality. The present invention further provides a direct strategy to extend hybrid technologies to related cereals such as sorghum and rice. Tasselseed and silkless genes represent major sex determination genes in maize, a pathway that permits the efficient production of hybrid seed and the associated benefits of heterosis-increased yield, resistance to pathogens, etc.
    Type: Application
    Filed: August 11, 2017
    Publication date: September 9, 2021
    Inventors: Stephen L. DELLAPORTA, Andrew HAYWARD, Maria MORENO, Albert KAUSCH, John MOTTINGER
  • Publication number: 20210206842
    Abstract: The present disclosure concerns antibodies specific for the Na v.7 polypeptides which are capable of antagonizing the biological activity of the Na v.7 polypeptide. The anti-Na v.7 antibodies can be used for alleviating the symptoms of pain and/or for treating or alleviating the symptoms of an hyperproliferative disease. The presence disclosure also concerns immunogens and methods for making antibodies, such as the anti-Na v.7 antibodies, comprising a single-domain antibody.
    Type: Application
    Filed: May 17, 2019
    Publication date: July 8, 2021
    Inventors: Marzia MARTINA, Balu CHAKRAVARTHY, Yves DUROCHER, Mehdi ARBABI-GHAHROUDI, Anne MARCIL, Danica STANIMIROVIC, Traian SULEA, Maria MORENO, Umberto BANDERALI
  • Publication number: 20200331964
    Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Application
    Filed: June 10, 2020
    Publication date: October 22, 2020
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
  • Publication number: 20200323534
    Abstract: An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.
    Type: Application
    Filed: June 26, 2020
    Publication date: October 15, 2020
    Applicant: MicroVention, Inc.
    Inventors: Jared Shimizu, Heath Bowman, Kiet Lam, Rohini Retarekar, Maria Moreno, Rogelio Cortez
  • Patent number: 10793600
    Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 6, 2020
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
  • Patent number: 10729447
    Abstract: An occlusive device, occlusive device delivery system, method of using, and method of delivering an occlusive device, and method of making an occlusive device to treat various intravascular conditions is described.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: August 4, 2020
    Assignee: MicroVention, Inc.
    Inventors: Jared Shimizu, Heath Bowman, Kiet Lam, Rohini Retarekar, Maria Moreno, Rogelio Cortez
  • Patent number: 10519099
    Abstract: The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: December 31, 2019
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel