Patents by Inventor Mariano Stivanello

Mariano Stivanello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of intermediates useful in the synthesis of imatinib
    Patent number: 8334381
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: December 18, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • METHOD FOR THE MANUFACTURING OF NALTREXONE
    Publication number: 20120116085
    Abstract: The present invention relates to an improved process for producing naltrexone[17-(cyclopropylmethyl)-4,5?-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone[4,5-?-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 10, 2012
    Applicant: H. Lundbeck A/S
    Inventors: Carla De Faveri, Florian Anton Martin Huber, Mariano Stivanello
  • Process for the preparation of imatinib and intermediates thereof
    Patent number: 8168787
    Abstract: A process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 1, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Process for the synthesis of terbinafine and derivatives thereof
    Patent number: 7838704
    Abstract: The present invention relates to a synthetic method for terbinafine and analogues thereof using metal catalysts, preferably Ni(II) salts and/or complexes.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: November 23, 2010
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Federico Della Negra, Cristiano Grandini, Mariano Stivanello
  • PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF
    Publication number: 20100234598
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Application
    Filed: May 20, 2010
    Publication date: September 16, 2010
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • PROCESS FOR THE PREPARATION OF IMATINIB AND INTERMEDIATES THEREOF
    Publication number: 20100076189
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Application
    Filed: November 15, 2007
    Publication date: March 25, 2010
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Process for the Synthesis of Terbinafine and Derivatives Thereof
    Publication number: 20070244336
    Abstract: The present invention relates to a synthetic method for terbinafine and analogues thereof using metal catalysts, preferably Ni(II) salts and/or complexes.
    Type: Application
    Filed: March 4, 2005
    Publication date: October 18, 2007
    Inventors: Federico Negra, Cristiano Grandini, Mariano Stivanello
  • Resolution of 3-amino alkylnitriles
    Patent number: 7026345
    Abstract: The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active ?-amino alkylnitriles, and also to a process for preparing optically active ?-amino alkylnitriles by resolving racemic ?-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.
    Type: Grant
    Filed: September 17, 2004
    Date of Patent: April 11, 2006
    Assignee: Pfizer Inc.
    Inventors: Juan Colberg, Samuela Zambelli Franz, Riccardo Motterle, Mariano Stivanello
  • Resolution of 3-amino alkylnitriles
    Publication number: 20050107453
    Abstract: The present invention relates to chiral N-acetyl-alpha-amino acid salts of optically active ?-amino alkylnitriles, and also to a process for preparing optically active ?-amino alkylnitriles by resolving racemic ?-amino alkylnitriles using chiral N-acetyl-alpha-amino acids as resolving agent.
    Type: Application
    Filed: September 17, 2004
    Publication date: May 19, 2005
    Inventors: Juan Colberg, Samuela Franz, Riccardo Motterle, Mariano Stivanello
  • Process for the synthesis of 1,7-diarly or heteroaryl-heptane-4-ols and new synthetic intermediates
    Patent number: 5973157
    Abstract: This invention offers a process for the synthesis of a compound of the formula ##STR1## wherein R' is a phenyl, a substituted phenyl, a heterocyclic aromatic group, a heterocyclic aromatic substituted group, a linear or branched alkyl group, or a cycloalkyl group.The invention also comprises the following compounds of a formula 1' and 2' as useful new synthesis intermediates. ##STR2## wherein R is a phenyl, a substituted phenyl, an alkyl, a cycloalkyl and X is Cl, Br, I, F, CH.sub.3 SO.sub.3, p--CH.sub.3 --C.sub.6 H.sub.4 --SO.sub.3.
    Type: Grant
    Filed: April 20, 1998
    Date of Patent: October 26, 1999
    Assignee: F.I.S. Fabbrica Iltaliana Sintetici S.p.A.
    Inventor: Mariano Stivanello
  • Process for preparing [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxylphenyl)-1-methyl-ethy l]-oxazolidin-2-one
    Patent number: 5663360
    Abstract: The present invention relates to a process for preparing [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)-1-methyl-ethyl]- oxazolidin-2-one of Formula (1), characterized in that said process comprises the step of reacting (R)-3, 4-methoxy-amphetamine of Formula (3), with (R)-3-chloro-mandelic acid, of Formula (9): ##STR1##
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: September 2, 1997
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Roberto Bortolaso, Mariano Stivanello