Patents by Inventor Mario Rottlander

Mario Rottlander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alcohol derivatives as KV7 potassium channel openers
    Patent number: 11548849
    Abstract: The present invention provides novel compounds (e.g., compounds of Formula I) which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: January 10, 2023
    Assignee: H. Lundbeck A/S
    Inventors: Mario Rottlander, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen, Anette Graven Sams, Krestian Larsen
  • ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS
    Publication number: 20220380300
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Application
    Filed: July 20, 2022
    Publication date: December 1, 2022
    Applicant: H. Lundbeck A/S
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS FOR USE IN EPILEPSY OR SEIZURES
    Publication number: 20220280455
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Applicant: H. Lundbeck A/S
    Inventors: Anette Graven Sams, Mario Rottlãnder, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen, Jesper Frank Bastlund, Jelena Ivkovic, Karina Krøjer Søby, Morten Grupe Larsen
  • Alcohol derivatives as KV7 potassium channel openers
    Patent number: 11434199
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: September 6, 2022
    Assignee: H. Lundbeck A/S
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS
    Publication number: 20210032196
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Inventors: Mario Rottlander, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen, Anette Graven Sams, Krestian Larsen
  • ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS
    Publication number: 20200172474
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Application
    Filed: February 4, 2020
    Publication date: June 4, 2020
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • Alcohol derivatives of carboxamides as Kv7 potassium channel openers
    Patent number: 10590067
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Exemplary compounds of the invention have the structure of Formula 1. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: March 17, 2020
    Assignee: H. Lundbeck A/S
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS
    Publication number: 20190256456
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Application
    Filed: February 20, 2018
    Publication date: August 22, 2019
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • Substituted pyridine derivatives
    Patent number: 8299071
    Abstract: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: October 30, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Nikolay Khanzhin, Mario Rottlander, William Patrick Watson, Daniel Rodriguez Greve
  • Substituted thiomorpholine derivatives
    Patent number: 8299075
    Abstract: The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: October 30, 2012
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Mario Rottlander, Nikolay Khanzhin, William Patrick Watson, Andreas Ritzen
  • SUBSTITUTED THIOMORPHOLINE DERIVATIVES
    Publication number: 20110294787
    Abstract: The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Application
    Filed: July 28, 2011
    Publication date: December 1, 2011
    Applicant: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornøe, Mario Rottländer, Nikolay Khanzhin, Andreas Ritzèn, William Patrick Watson
  • Substituted thiomorpholine derivatives
    Patent number: 8012962
    Abstract: The present invention relates to thiomorpholine derivatives of formula I or pharmaceutically acceptable salts thereof and their use in treating seizure disorders, anxiety disorders, bipolar disorders, neuropathic pain disorders and migraine pain disorders.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: September 6, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Mario Rottlander, Nikolay Khanzhin, Andreas Ritzen, William Patrick Watson
  • Substituted p-diaminobenzene derivatives
    Patent number: 7906537
    Abstract: The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: March 15, 2011
    Assignee: H. Lundbeck A/S
    Inventors: Nikolay Khanzhin, Mario Rottlander, Andreas Ritzen, William P. Watson
  • SUBSITUTED PYRIDINE DERIVATIVES
    Publication number: 20110003811
    Abstract: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.
    Type: Application
    Filed: September 14, 2010
    Publication date: January 6, 2011
    Applicant: H. LUNDBECK A/S
    Inventors: Christian Wenzel Tornøe, Nikolay Khanzhin, Mario Rottländer, William Patrick Watson, Daniel Rodriguez Greve
  • Substituted pyridine derivatives
    Patent number: 7812020
    Abstract: The present invention relates to pyridine derivatives of the general formula (I) and their use as openers of the KCNQ family potassium ion channels for the treatment of CNS disorders.
    Type: Grant
    Filed: March 2, 2006
    Date of Patent: October 12, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornøe, Nikolay Khanzhin, Mario Rottländer, William Patrick Watson, Daniel Rodriguez Greve
  • Methods of using substituted morpholine derivatives
    Patent number: 7812023
    Abstract: The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Grant
    Filed: November 5, 2009
    Date of Patent: October 12, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornøe, Mario Rottländer, Nikolay Khanzhin, Andreas Ritzèn, William Patrick Watson
  • SUBSTITUTED PYRIMIDINE DERIVATIVES
    Publication number: 20100137311
    Abstract: The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use.
    Type: Application
    Filed: January 30, 2010
    Publication date: June 3, 2010
    Applicant: H. LUNDBECK A/S
    Inventors: Nikolay Khanzhin, Daniel Rodriguez Greve, Mario Rottländer
  • Substituted pyrimidine derivatives
    Patent number: 7683058
    Abstract: The present invention relates to pyrimidine derivatives of the general formula I or salts thereof and their use.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: March 23, 2010
    Assignee: H. Lundbeck A/S
    Inventors: Nikolay Khanzhin, Daniel Rodriguez Greve, Mario Rottländer
  • Methods of using substituted morpholine derivatives
    Publication number: 20100063033
    Abstract: The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.
    Type: Application
    Filed: November 5, 2009
    Publication date: March 11, 2010
    Inventors: Christian Wenzel Tornøe, Mario Rottländer, Nikolay Khanzhin, Andreas Ritzén, William Patrick Watson
  • SUBSTITUTED ANILINE DERIVATIVES
    Publication number: 20100063044
    Abstract: The present invention relates to aniline derivatives of formula I: wherein R1, R2, R3, R4, Z and q are as defined herein; or salts thereof and their use.
    Type: Application
    Filed: August 17, 2009
    Publication date: March 11, 2010
    Applicant: H. Lundbeck A/S
    Inventors: Christian Wenzel Tornoe, Mario Rottlãnder, Daniel Rodriguez Greve, Nikolay Khanzhin, Andreas Ritzén, William Patrick Watson