Patents by Inventor Mark A. Cunningham

Mark A. Cunningham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treatment using human anti-IL-23 antibodies
    Patent number: 8221760
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: July 17, 2012
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • DIHYDROFOLATE REDUCTASE INHIBITORS
    Publication number: 20120136014
    Abstract: The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.
    Type: Application
    Filed: June 2, 2011
    Publication date: May 31, 2012
    Applicant: TRIUS THERAPEUTICS, INC.
    Inventors: Zhiyong Chen, Christopher J. Creghton, Mark Cunningham, John Finn, Mark Hilgers, Michael Jung, Lucy Aguirre Kohnen, Thanh Lam, Xiaoming Li, Mark Stidham, Les Tari, Michael Trzoss, Junhu Zhang
  • Toll like receptor 3 antagonists, methods and uses
    Patent number: 8153583
    Abstract: Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists, and methods of making and using the foregoing are disclosed.
    Type: Grant
    Filed: November 30, 2005
    Date of Patent: April 10, 2012
    Inventors: Jill M. Carton, Shizhong Chen, Mark Cunningham, Anuk Das, Karen Duffy, Jill M. Giles-Komar, Theresa J. Goletz, David M. Knight, Roberta Lamb, Mouhamadou L. Mbow, Kristen Picha, Gopalan Raghunathan, Lani San Mateo, Robert T. Sarisky, Vedrana Stojanovic-Susulic, Nicole Stowell, Raymond Sweet, Shanrong Zhao
  • TOLL-LIKE RECEPTOR 3 ANTAGONISTS FOR THE TREATMENT OF METABOLIC AND CARDIOVASCULAR DISEASES
    Publication number: 20120064095
    Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 15, 2012
    Inventors: Mark Cunningham, Yiqing Feng, Katharine Heeringa, Jinquan Luo, Robert Rauchenberger, Mark Rutz, Lani San Mateo, Robert Sarisky, Vedrana Stojanovic-Susulic, Raymond Sweet, Fang Teng, Alexey Teplyakov, Linda Wu, Sheng-Jiun Wu
  • Nucleic acids encoding human anti-IL-23 antibodies
    Patent number: 8106177
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: January 31, 2012
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • METHODS FOR GENERATING ANTI-IL-23 ANTIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20110319292
    Abstract: A protein variant of IL-23p19 that has conserved residues in positions 93-102, 93-110, and/or 127-137 of SEQ ID NO:1, can be used to generate anti-IL-23p19 antibodies.
    Type: Application
    Filed: September 13, 2011
    Publication date: December 29, 2011
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Methods of Treatment Using Human Anti-IL-23 Antibodies
    Publication number: 20110287028
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: June 30, 2011
    Publication date: November 24, 2011
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • ANTI-CD147 ANTIBODIES, METHODS AND USES
    Publication number: 20110200627
    Abstract: The present invention provides antibodies immunospecific for human CD 147 capable of blocking bioactivity of CD 147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD 147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
    Type: Application
    Filed: August 19, 2009
    Publication date: August 18, 2011
    Inventors: Mark Cunningham, Bethany Swencki-Underwood, Yi Tang, Li Yan
  • Nucleic Acids Encoding Human Anti-IL-23 Antibodies
    Publication number: 20110195455
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: April 4, 2011
    Publication date: August 11, 2011
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • Human anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 7993645
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: August 9, 2011
    Assignee: Janssen Biotech, Inc.
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • Human anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 7935344
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: May 3, 2011
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Jacqueline Benson, Jill Carton, Mark Cunningham, Yevgeniya I. Orlovsky, Robert Rauchenberger, Raymond Sweet
  • Melanocortin receptor binding mimetibodies, compositions, methods and uses
    Patent number: 7910101
    Abstract: Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 22, 2011
    Assignee: Centocor, Inc.
    Inventors: Mark Cunningham, Vedrana Stojanovic-Susulic, Karyn O'Neil, Chichi Huang, Jeffrey Luo
  • Human Anti-IL-23 Antibodies, Compositions, Methods and Uses
    Publication number: 20110040249
    Abstract: A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 17, 2011
    Inventors: JACQUELINE BENSON, JILL CARTON, MARK CUNNINGHAM, YEVGENIYA I. ORLOVSKY, ROBERT RAUCHENBERGER, RAYMOND SWEET
  • Toll-Like Receptor 3 Antagonists
    Publication number: 20110008352
    Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: April 29, 2010
    Publication date: January 13, 2011
    Inventors: Mark Cunningham, Yiqing Feng, Katharine Heeringa, Jinquan Luo, Robert Rauchenberger, Mark Rutz, Lani San Mateo, Robert Sarisky, Raymond Sweet, Fang Teng, Alexey Teplyakov, Sheng-Jiun Wu
  • Methods and Uses of Anti-IL-23 Antibodies
    Publication number: 20100322863
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: August 31, 2010
    Publication date: December 23, 2010
    Inventors: JACQUELINE BENSON, MARK CUNNINGHAM, CYNTHIA DUCHALA, JILL M. GILES-KOMAR, JINQUAN LUO, MICHAEL A. RYCYZYN, SWEET RAYMOND
  • IL-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses
    Patent number: 7807471
    Abstract: An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.
    Type: Grant
    Filed: June 26, 2007
    Date of Patent: October 5, 2010
    Assignee: Centocor Ortho Biotech, Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Jeffrey (Sinquan) Luo
  • Anti-IL-23 antibodies, compositions, methods and uses
    Patent number: 7807414
    Abstract: An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: October 5, 2010
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Jacqueline Benson, Mark Cunningham, Cynthia Duchala, Jill M. Giles-Komar, Jinquan Luo, Michael A. Rycyzyn, Sweet Raymond
  • Implantable pump for protein delivery for obesity control by drug infusion into the brain
    Patent number: 7790671
    Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: September 7, 2010
    Assignee: Codman & Shurtleff, Inc.
    Inventors: Vedrana Stojanovic-Susulic, Ramakrishna Venugopalan, Mark Cunningham
  • IMPLANTABLE PUMP FOR PROTEIN DELIVERY FOR OBESITY CONTROL BY DRUG INFUSION INTO THE BRAIN
    Publication number: 20100183700
    Abstract: Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
    Type: Application
    Filed: February 22, 2010
    Publication date: July 22, 2010
    Applicant: CODMAN & SHURTLEFF, INC.
    Inventors: Vedrana Stojanovic-Susulic, Ramakrishna Venugopalan, Mark Cunningham
  • Toll-Like Receptor 3 Antagonists
    Publication number: 20100166778
    Abstract: Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: October 30, 2009
    Publication date: July 1, 2010
    Inventors: Mark Cunningham, Yiqing Feng, Katharine Heeringa, Jinquan Luo, Robert Rauchenberger, Mark Rutz, Lani San Mateo, Robert Sarisky, Raymond Sweet, Fang Teng, Alexey Teplyakov, Sheng-Jiun Wu