Patents by Inventor Mark A. Gallop

Mark A. Gallop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINO ACID CONJUGATES PROVIDING FOR SUSTAINED SYSTEMIC CONCENTRATION OF GABA ANALOGUES
    Publication number: 20080226716
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Application
    Filed: May 28, 2008
    Publication date: September 18, 2008
    Applicant: XenoPort
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
    Patent number: 7423169
    Abstract: The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: September 9, 2008
    Assignee: Xenoport, Inc.
    Inventors: Stephen P. Raillard, Cindy X. Zhou, Fenmei Yao, Suresh Kumar Manthati, Jia-Ning Xiang, Mark A. Gallop
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7420002
    Abstract: Compounds that provide for sustained systemic concentrations of GABA analogs following oral administration to animals are disclosed. Pharmaceutical compositions including, and methods using, such compounds are also disclosed.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: September 2, 2008
    Assignee: Xenoport
    Inventors: Mark Gallop, Kenneth C. Cundy, Randall A. Scheuerman, Ronald W. Barrett, Noa Zerangue
  • Substrates and screening methods for transport proteins
    Patent number: 7413536
    Abstract: A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: August 19, 2008
    Assignee: XenoPort, Inc.
    Inventors: William J. Dower, Mark A. Gallop, Ronald W. Barrett, Kenneth C. Cundy, Tania Chernov-Rogan
  • ACYLOXYALKYL CARBAMATE PRODRUGS OF TRANEXAMIC ACID, METHODS OF SYNTHESIS AND USE
    Publication number: 20080153898
    Abstract: Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
    Type: Application
    Filed: October 12, 2007
    Publication date: June 26, 2008
    Inventors: Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A. Gallop
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Publication number: 20080146526
    Abstract: Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
    Type: Application
    Filed: September 13, 2007
    Publication date: June 19, 2008
    Inventors: Mark A. Gallop, Feng Xu, Thu Phan, Usha Dilip, Ge Peng
  • Levodopa prodrugs, and compositions and uses thereof
    Publication number: 20080132570
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: January 10, 2008
    Publication date: June 5, 2008
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou
  • Levodopa prodrugs, and compositions and uses thereof
    Publication number: 20080103200
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: December 11, 2007
    Publication date: May 1, 2008
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark Gallop, Cindy Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth Cundy
  • ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE
    Publication number: 20080096960
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: October 24, 2007
    Publication date: April 24, 2008
    Inventors: Mark Gallop, Fenmei Yao, Maria Ludwikow, Thu Phan, Ge Peng
  • Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
    Patent number: 7351740
    Abstract: Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl) -cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl) -cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl) -cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: April 1, 2008
    Assignee: XenoPort, Inc.
    Inventors: Noa Zerangue, Bernd Jandeleit, Yunxiao Li, Mark A. Gallop
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7342131
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: March 11, 2008
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Methods for Synthesis of Acyloxyalkyl Derivatives of GABA Analogs
    Publication number: 20080058546
    Abstract: The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
    Type: Application
    Filed: November 1, 2007
    Publication date: March 6, 2008
    Inventors: Stephen Raillard, Cindy Zhou, Fenmei Yao, Suresh Manthati, Jia-Ning Xiang, Mark Gallop
  • Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
    Publication number: 20080051458
    Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
    Type: Application
    Filed: July 26, 2007
    Publication date: February 28, 2008
    Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark Gallop
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7323585
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: June 3, 2005
    Date of Patent: January 29, 2008
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy
  • Gemcitabine Prodrugs, Pharmaceutical Compositions and Uses Thereof
    Publication number: 20080021208
    Abstract: The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions of using gemcitabine prodrugs to treat or prevent diseases or disorders such as cancer or viral infections.
    Type: Application
    Filed: August 24, 2007
    Publication date: January 24, 2008
    Applicant: XenoPort, Inc.
    Inventors: Mark Gallop, Ge Peng, Thomas Woiwode, Kenneth Cundy
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Patent number: 7300956
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: November 27, 2007
    Assignee: Xenoport, Inc.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • 2'-C-Methyl-Ribofuranosyl Cytidine Prodrugs, Pharmaceutical Compositions and Uses Thereof
    Publication number: 20070270374
    Abstract: The present disclosure provides 2?-C-methyl-ribofuranosyl cytidine prodrugs, methods of making 2?-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions of 2?-C-methyl-ribofuranosyl cytidine prodrugs, and methods of using 2?-C-methyl-ribofuranosyl cytidine prodrugs and pharmaceutical compositions thereof to treat viral diseases such as hepatitis C.
    Type: Application
    Filed: May 22, 2007
    Publication date: November 22, 2007
    Inventor: Mark A. Gallop
  • Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof
    Publication number: 20070244331
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: May 25, 2007
    Publication date: October 18, 2007
    Inventors: Mark GALLOP, Xuedong Dai, Randall Scheuerman, Stephen Raillard, Suresh Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
    Patent number: 7265096
    Abstract: The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as cancer or viral infections.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: September 4, 2007
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Ge Peng, Thomas F. Woiwode, Kenneth C. Cundy
  • CORNEAL TOPOGRAPHER
    Publication number: 20070188709
    Abstract: A corneal topographer, and a method for corneal topography are disclosed. In one embodiment, the topographer includes an illumination projection subsystem to project a series of preselected different stationary patterns of one or more slits of light in ordered succession onto the surface of the cornea. An image capture subsystem captures a still image of each projected pattern. An image processing subsystem converts the still images into topographical information of the cornea. The method involves projecting a series of preselected different stationary patterns of one or more slits of light in ordered succession onto the surface of the cornea, capturing a still image of each projected pattern and converting the still images into topographical information of the cornea.
    Type: Application
    Filed: April 16, 2007
    Publication date: August 16, 2007
    Applicant: Clearmark Technologies Pty, Ltd.
    Inventors: Paul Saarloos, Mark Gallop, Robert Ellelboom