Patents by Inventor Mark A. Gallop

Mark A. Gallop has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of propofol, compositions and uses thereof
    Patent number: 7241807
    Abstract: The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.
    Type: Grant
    Filed: July 12, 2005
    Date of Patent: July 10, 2007
    Assignee: XenoPort, Inc.
    Inventors: Feng Xu, Mark A. Gallop
  • Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
    Patent number: 7232924
    Abstract: The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: June 19, 2007
    Assignee: Xenoport, Inc.
    Inventors: Stephen P. Raillard, Cindy X. Zhou, Fenmei Yao, Suresh Kumar Manthati, Jia-Ning Xiang, Mark A. Gallop
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Publication number: 20070135356
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Application
    Filed: January 18, 2007
    Publication date: June 14, 2007
    Applicant: XenoPort
    Inventors: Randall Scheuerman, Mark Gallop, Kenneth Cundy, Ronald Barrett
  • Compounds displayed on icosahedral phage and methods of using same
    Patent number: 7229757
    Abstract: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: June 12, 2007
    Assignee: Xenoport, Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Mark Gallop, Thomas F. Woiwode, Steven E. Cwirla
  • Aromatic prodrugs of propofol, compositions and uses thereof
    Patent number: 7230003
    Abstract: Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: June 12, 2007
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Feng Xu
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Patent number: 7227028
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Grant
    Filed: December 30, 2004
    Date of Patent: June 5, 2007
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Xuedong Dai, Randall A. Scheuerman, Stephen P. Raillard, Suresh K. Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Amino acid derived prodrugs of propofol, compositions and uses thereof
    Patent number: 7220875
    Abstract: The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: May 22, 2007
    Inventors: Mark A. Gallop, Feng Xu, Kenneth C. Cundy, Vivek Susikumar, Thomas W. Woiwode
  • Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use
    Patent number: 7208611
    Abstract: Platinum containing compounds exhibiting cytostatic activity, methods of synthesizing platinum-containing compounds exhibiting cytostatic activity pharmaceutical compositions comprising platinum containing compounds, and methods of using such compounds and compositions for treating cancer are disclosed.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 24, 2007
    Assignee: XenoPort, Inc.
    Inventors: Qingzhi Gao, Mark A. Gallop, Jia-Ning Xiang
  • COMPOUNDS DISPLAYED ON ICOSAHEDRAL PHAGE AND METHODS OF USING SAME
    Publication number: 20070082330
    Abstract: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen a library of compounds for a desired biological activity are also provided, especially assays for compounds that are substrates for receptor-mediated transport processes such as endocytosis and transcytosis.
    Type: Application
    Filed: March 21, 2002
    Publication date: April 12, 2007
    Applicant: XenoPort, Inc.
    Inventors: Ronald Barrett, William Dower, Mark Gallop, Thomas Woiwode, Steven Cwirla
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Publication number: 20070054945
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Application
    Filed: August 21, 2006
    Publication date: March 8, 2007
    Applicant: XenoPort, Inc.
    Inventors: Mark Gallop, Fenmei Yao, Maria Ludwikow, Thu Phan, Ge Peng
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7186855
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: March 6, 2007
    Assignee: Xenoport, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang Gregory Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollman
  • Amino acid conjugates providing for sustained systemic concentrations of GABA analogues
    Patent number: 7183259
    Abstract: This invention is directed to compounds that provide for sustained systemic concentrations of GABA analogs following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such compounds.
    Type: Grant
    Filed: May 13, 2003
    Date of Patent: February 27, 2007
    Assignee: XenoPort
    Inventors: Randall A. Scheuerman, Mark A. Gallop, Kenneth C. Cundy, Ronald W. Barrett
  • Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
    Publication number: 20070037988
    Abstract: Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
    Type: Application
    Filed: December 30, 2004
    Publication date: February 15, 2007
    Inventors: Mark Gallop, Xuedong Dai, Randall Scheuerman, Stephen Raillard, Suresh Manthati, Fenmei Yao, Thu Phan, Maria Ludwikow, Ge Peng, Seema Bhat
  • Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
    Publication number: 20070015716
    Abstract: Disclosed are methods for providing enhanced systemic blood concentrations of orally delivered drugs that are incompletely translocated across the intestinal wall of an animal. Also disclosed are methods for the sustained release of drugs, whether poorly or readily bioavailable via oral delivery to animals. Still further, disclosed are compounds and pharmaceutical compositions that are used in such methods.
    Type: Application
    Filed: July 11, 2006
    Publication date: January 18, 2007
    Inventors: Mark Gallop, Kenneth Cundy
  • Prodrugs of GABA analogs, compositions and uses thereof
    Publication number: 20070010453
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: May 22, 2006
    Publication date: January 11, 2007
    Inventors: Mark Gallop, Kenneth Cundy, Cindy Zhou, Fayang Qiu, Fenmei Yao, Jia-Ning Xiang, Ian Ollmann
  • Aromatic prodrugs of propofol, compositions and uses thereof
    Publication number: 20060287525
    Abstract: Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.
    Type: Application
    Filed: August 21, 2006
    Publication date: December 21, 2006
    Inventors: Mark Gallop, Feng Xu
  • Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
    Publication number: 20060287250
    Abstract: The synthesis of 1-(acyloxy)-alkyl carbamates of GABA analogs from 1-haloalkyl carbamates of GABA analogs are described. Also described are new 1-haloalkyl carbamates of GABA analogs.
    Type: Application
    Filed: August 21, 2006
    Publication date: December 21, 2006
    Inventors: Stephen Raillard, Cindy Zhou, Fenmei Yao, Suresh Manthati, Jia-Ning Xiang, Mark Gallop
  • Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
    Patent number: 7144877
    Abstract: Disclosed are methods for providing enhanced systemic blood concentrations of orally delivered drugs that are incompletely translocated across the intestinal wall of an animal. Also disclosed are methods for the sustained release of drugs, whether poorly or readily bioavailable via oral delivery to animals. Still further, disclosed are compounds and pharmaceutical compositions that are used in such methods.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: December 5, 2006
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy
  • Prodrugs of GABA analogs, compositions and uses thereof
    Publication number: 20060229361
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: April 6, 2005
    Publication date: October 12, 2006
    Inventors: Mark Gallop, Kenneth Cundy, Cindy Zhou, Fenmei Yao, Jia-Ning Xiang, Ian Ollman, Fayang Qiu
  • Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
    Patent number: 7109239
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: September 19, 2006
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng