Abstract: A gastrectomy device includes an elongated member defining a centerline that extends through proximal and distal ends thereof. A shape modification member coupled to the elongated member is movable relative to the centerline of the elongated member. The shape modification member is movable between a first state, adjacent to the elongated member, and a second state, spaced from the elongated member. The shape modification member conforms to a portion of a patient's stomach in the second state.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including Dravet syndrome or epilepsy are also provided herein.

Abstract: A road embedded battery includes a first encapsulation layer disposed on top of a road grade base. A first conductor mesh is disposed on top of the first encapsulation layer and an anode material is embedded into to first conductor mesh. A permeable membrane is disposed on top of the anode material. A second conductor mesh is disposed on top of the permeable membrane and a cathode material is embedded into the second conductor mesh. A second encapsulation layer is disposed on top of the cathode material.

Abstract: A gastrectomy device includes an elongated member defining a centerline that extends through proximal and distal ends thereof. A shape modification member coupled to the elongated member is movable relative to the centerline of the elongated member. The shape modification member is movable between a first state, adjacent to the elongated member, and a second state, spaced from the elongated member. The shape modification member conforms to a portion of a patient's stomach in the second state.

Abstract: A device 10 for gathering tissue in a patient includes an elongated catheter 14 and a capture assembly 13 at a distal portion of the catheter. The capture assembly has a closed side 18 and a door 20 rotatable between an open condition and a closed condition. The closed side 18 of the capture assembly 13 and the door 20 in the closed condition may collectively define a tissue capturing compartment 19. Movement of the door 20 from the open condition to the closed condition adjacent the tissue may capture a portion 44 of the tissue in the tissue capturing compartment 19. A clip may then be applied from the capture assembly 13 to the captured tissue 44 to hold the tissue substantially in a gathered configuration.

Abstract: A device 10 for repairing mitral valve leaflets 2, 3 includes a jaw mechanism 15 that may be positioned adjacent a mitral valve leaflet 2, 3. The jaw mechanism 15 may move between an open position and a closed position by pivoting a first jaw relative 16 to a second jaw 18. The first jaw 16 may include a rivet 28 that may move from a stored position to an application position projecting away from the first jaw 16 when the jaw mechanism 15 is moved from the closed to the open position. Closing the jaws 16, 18 about a valve leaflet 2, 3 causes the rivet 28 to pierce the leaflet. The jaw mechanism 15 may then be rotated to wind the leaflet 2, 3 thereabout and again pierce the leaflet. The rivet 28 may then be released from the jaw mechanism 25 and the device 10 removed from the patient.

Abstract: The present invention provides a fatty acid mixture enriched with palmitoleic acid and palmitoleic acid derivatives relative to the starting lipid mixture; fractionations procedure describe herein are winterization methods. The invention provides methods of dry winterization and solvent-aided winterization alone and in combination. In some embodiments, the palmitoleic acid and palmitoleic acid derivative enriched mixture described herein contains less than 1% of palmitic acid and palmitic acid derivative. The invention also provides palmitoleic derivatives of use as dietary supplements.

Abstract: The inventive system processes large quantities of client data. The inventive system can include an inbound message gateway (IMG) which receives event data from a plurality of clients. The IMG performs one or more processes on the event data and transmits sample data streams to an analytics cluster that includes a plurality of physical hardware nodes. Each of the physical hardware nodes can include a plurality of processes at a plurality of different time granularities. Database shards store recorded data from each of the processes in the physical nodes.

Abstract: A rack and a method of assembling the rack are disclosed that includes guard plates welded to right and left sides of a tubular frame. Each guard plate includes a fixed bushing. A locking bar pivots on pivot bushings provided on right and left swing arms. Right and left pins are assembled into one of the fixed and pivot bushings with a head of each pin contacting one pivot bushing, and a shaft of each pin being welded to the fixed bushing.

Abstract: A method of gathering tissue of a heart valve leaflet 2 may include inserting an elongated catheter assembly 12 to a position adjacent the heart valve leaflet, the catheter assembly including a capture tool 22 and a tissue support member 30. The capture tool 22 and the tissue support member 30 may each be independently moveable between a retracted position and an extended position. Partially retracting the capture tool 22 with the tissue support member 30 in the extended position gathers tissue 15 of the heart valve leaflet 2 between the capture tool and the tissue support member. A clip 55 may then be applied from the catheter assembly 12 to the gathered tissue 15 to hold the tissue substantially in a gathered configuration.

Abstract: An apparatus for gathering of tissue of a heart valve leaflet comprises an elongated member and a grasping assembly movable in the elongated member between a retracted position and an extended position. The grasping assembly includes an actuating arm having a proximal end and a distal end. The grasping assembly is attached to the distal end of the activating arm. The grasping assembly is operable to gather and clamp the tissue of the heart valve leaflet such that clamped tissue has a gathered configuration.

Abstract: A guiding sheath has a braided layer for improved deflection characteristics and ring electrodes for electrical sensing, mapping and visualization, wherein lead wires for the ring electrodes are passed through lumened tubing position under the braided layer in a proximal portion of the guiding sheath shaft and above the braided layer in a distal portion of the guiding sheath shaft. Moreover, the hemostatic valve includes an improved friction ring with air vents to reduce the risk of air being introduced into the valve.

Abstract: A tissue clipping apparatus comprises a clip including a proximal end received within a capsule. The clip includes a clip locking member biased to engage a first locking structure of the capsule to lock the clip in the capsule in a closed configuration. The apparatus also comprises a tension member releasably coupling the clip to a proximal end of the device which, during use, remains accessible to a user. The tension member is coupled to the clip by a joint designed to release when subject to a predetermined load to separate the clip from the device, release of the joint releasing the locking member to engage the first locking structure.

Abstract: A tissue clipping apparatus comprises a clip including a proximal end received within a capsule. The clip includes a clip locking member biased to engage a first locking structure of the capsule to lock the clip in the capsule in a closed configuration. The apparatus also comprises a tension member releasably coupling the clip to a proximal end of the device which, during use, remains accessible to a user. The tension member is coupled to the clip by a joint designed to release when subject to a predetermined load to separate the clip from the device, release of the joint releasing the locking member to engage the first locking structure.

Abstract: A device for repair of a heart valve leaflet includes an elongated catheter assembly having a proximal end and a distal end, and a tip at the distal end of the catheter assembly. A capture mechanism having a first free end and a second free end is rotatably coupled to a distal end of the tip. A plication mechanism has an open configuration and a closed configuration, and extends between the first free end and the second free end of the capture mechanism when in the open configuration. The device may also include a clip housing at a proximal end of the tip configured to hold a clip therein.

Abstract: Systems, methods, and computer programs for monitoring production of fluids from a subterranean formation includes receiving, from a first sensor array at a first time, a first set of electromagnetic signals generated by an electroseismic or seismoelectric conversion of seismic signals caused, at least in part, by the production of fluid from the subterranean formation; receiving, from the first sensor array at a second time, a second set of electromagnetic signals generated by an electroseismic or seismoelectric conversion of seismic signals caused, at least in part, by the production of fluid from the subterranean formation; and determining one or more reservoir properties based, at least in part, on the first and second sets signals received from the first sensor array.

Abstract: The present invention concerns phospholipid compositions having a relatively high concentration of compounds of the following structure (I): wherein at least one of R1 and R2 is palmitoleoyl, myristoleoyl or lauroleoyl and methods for their preparation. The present invention also concerns the use of these phospholipid compositions to treat a variety of disorders by administering the composition to a patient in need thereof.

Abstract: A gastrectomy device includes an elongated member defining a centerline that extends through proximal and distal ends thereof. A shape modification member coupled to the elongated member is movable relative to the centerline of the elongated member. The shape modification member is movable between a first state, adjacent to the elongated member, and a second state, spaced from the elongated member. The shape modification member conforms to a portion of a patient's stomach in the second state.

Abstract: A device 10 for gathering tissue in a patient includes an elongated catheter 14 and a capture assembly 13 at a distal portion of the catheter. The capture assembly has a closed side 18 and a door 20 rotatable between an open condition and a closed condition. The closed side 18 of the capture assembly 13 and the door 20 in the closed condition may collectively define a tissue capturing compartment 19. Movement of the door 20 from the open condition to the closed condition adjacent the tissue may capture a portion 44 of the tissue in the tissue capturing compartment 19. A clip may then be applied from the capture assembly 13 to the captured tissue 44 to hold the tissue substantially in a gathered configuration.