Abstract: Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.

Abstract: Porous polymer microspheres having a size of from about 3 to about 50 microns and a geometric standard deviation of about 1.25 or less are disclosed. The porous polymer microspheres are made by a method including the steps of preparing an emulsion comprised of polymer particles having an average particle size of less than about 3 microns and a diluent, subjecting the emulsion to an aggregating condition to form aggregated polymer particles, optionally coalescing the aggregated polymer particles, and removing the diluent to form the porous polymer microspheres.

Abstract: A printhead IC comprising: an array of nozzles having a plurality of adjacent regions; and, drive circuitry for sending an electrical pulse to each of the nozzles individually such that they eject a drop of printing fluid; and, a plurality of temperature sensors for sensing the temperature of the printhead IC within each of the regions respectively.

Abstract: A printhead controller is provided for supplying print data to a printhead having first and second rows of inkjet nozzles configured to print ink of a similar color. The controller is configured to supply the print data to the printhead such that, in the event a nozzle in the first row is faulty, a corresponding nozzle in the second row prints at a position on print media at or adjacent a position where the faulty nozzle would otherwise have printed.

Abstract: A printhead having at least first and second rows of print nozzles. Each nozzle has first circuitry of a first type arranged asymmetrically to second circuitry of a second type. The respective positions of the first and second circuitry of each nozzle of the first row are arranged mirrored with respect to the first and second circuitry of each nozzle of the second row.

Abstract: A printhead IC is provided having ejection nozzles, drive circuitry for sending drive pulses to resistive heaters of the nozzles to cause ejection from the nozzles, sensing circuitry being activated to sense the temperature of the printhead IC and adjust the profile of the sent drive pulses in accordance with the sensed temperature and being de-activated after a period of use, and test circuitry for selectively disabling the resistive heaters when they receive the drive pulses while comparing the resistance of the resistive heaters against a predetermined threshold to assess whether the resistive heaters are defective.

Abstract: A printer includes a printhead having first and second elongate printhead modules; and first and second printer controllers receiving print data and processing the print data to output dot data to the printhead, the first printer controller outputting dot data to the first printhead module and the second printer controller outputting dot data to the second printhead module. The first elongate printhead module is informationally isolated from the second elongate printhead module, whereby no dot data passes therebetween. The first printer controller and the second printer controller communicate therebetween a synchronization signal to effect synchronization therebetween.

Abstract: A variable format signature collection apparatus is provided. The variable format signature collection apparatus includes a sprocket and a timing belt traveling about the sprocket. The timing belt includes a plurality of gripper mounts. The gripper mounts include a first set of gripper mounts arranged on the timing belt to support grippers for receiving first signatures of a first cutoff length and a second set of gripper mounts positioned to support grippers for receiving second signatures of a second cutoff length.

Abstract: A print engine is provided which has a printhead capable of printing a maximum of n channels of print data and a controller. Each channel is associated with rows of printing nozzles of the printhead. The controller controls the printhead to print in: a first mode, in which the printhead receives from the controller, print data for a first number of the channels; and a second mode, in which the printhead receives from the controller, print data for a second number of the channels less than the first number and dummy data for a portion of each nozzle row associated with the remaining number of the channels. The first number is less than n.

Abstract: A manufacturing system including an apparatus in which a plurality differently configured workpieces requiring manufacturing operations are processed. The apparatus includes a work surface configured to receive apparatus components and a plurality of differently configured workpieces, a tool table adjacent the work surface providing support for tooling and apparatus components required to process various manufacturing operations on the workpieces, and a robotic manipulator positioned adjacent to the work surface and the tool table and having a gripping device configured to grip at least one of the apparatus components. Also, an automated feed system optionally included in the system for supplying component parts to the manufacturing operation. Also, a method of assembling first and second differently configured workpieces.

Abstract: A wheelchair includes a frame, and a front pivot arm pivotally mounted to the frame at a front pivot point, the front pivot arm having a caster for supporting the frame. A rear pivot arm is pivotally mounted to the frame at a rear pivot point, the rear pivot arm having a caster for supporting the frame. A ground engaging mid-wheel drive wheel is connected to the frame. A linkage connects the front and rear pivot arms to each other in a manner such that an upward or downward rotation of one of the pivot arms about its pivot point causes rotation of the other pivot arm about its pivot point in an opposite rotational direction.

Abstract: A printhead is provided having a plurality of nozzle rows which have displaced row portions. The displaced row portions of at least some of the rows are different in length than the displaced row portions of at least some of the other rows.

Abstract: A printhead IC for receiving print data from a print engine controller (PEC) which may be one of a plurality of different types of PEC. The printhead IC has an array of nozzles for ejecting drops of printing fluid onto a media substrate and drive circuitry for driving the array of nozzles. The drive circuitry is configured for connection to a power source in the printer. The drive circuitry is configured to reset itself to a known initial state in response to receiving power from the power source after a period of not receiving power from the power source.

Abstract: A printhead is provided which has a plurality of types of printheads modules. Each type of module is determined by its geometric shape in plan so that the combination of the determined module types forms the printhead to extend and print across a pagewidth. At least one row of printhead nozzles defined across the determined types of modules includes at least one displaced row portion.

Abstract: Provided is a print engine controller for an inkjet printhead with a plurality of nozzle arrangements operatively actuated by thermal actuators. The controller has controller circuitry with an open actuator test circuit to test each respective actuator. The controller circuitry includes an open actuator test input, a column enable input and a row enable input, as well as a drive transistor operatively linking said thermal actuator to a power supply. The circuitry also includes a bleed transistor arranged in parallel with the thermal actuator, and a sense transistor operatively linking an output of the drive transistor and inputs of the thermal actuator and bleed transistor to a sensing node. The controller circuitry is configured so that when only the column enable and row enable inputs are activated the bleed and sense transistors are deactivated and the drive transistor is activated to link the thermal actuator to the power supply.

Abstract: Microsclerotia of entomopathogenic fungi, including Metarhizium species, Beauveria species, and Lecanicillium species, may be produced. These microsclerotia are effective for the control of a wide variety of insect pests, particularly soil-dwelling insect pests.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: A printhead IC is provided having an ejection nozzle having a heater for heating printing fluid, and drive circuitry for generating print pulses and maintenance pulses for driving the heater of the ejection nozzle. The maintenance pulses have a series of sub-ejection pulses preceding a de-clog pulse. The print signals are generated to heat the heater to form a first vapor bubble in printing fluid that causes ejection of the printing fluid from the nozzle. The de-clog pulse is generated to have lower power and longer duration than the print pulses so as to heat the heaters to form a second vapor bubble in the printing fluid which does not cause ejection. The sub-ejection pulses are generated to have lower power than the print pulses and shorter duration than the de-clog pulse so as to heat the heater without sufficient energy to nucleate a vapor bubble in the printing fluid.

Abstract: Provided is a printhead integrated circuit for an inkjet printer that has a nozzle and a corresponding actuator for ejecting ink through the nozzle. The Printhea IC also has drive circuitry for controlling the operation of the actuator. The drive circuitry has an open actuator test circuit comprising an open actuator test input, a column enable input and a row enable input, a drive transistor operatively linking said actuator to a power supply, a bleed transistor arranged in parallel with the actuator, a sense transistor operatively linking an output of the drive transistor and inputs of the actuator and bleed transistor to a sensing node. Actuating the actuator to eject ink by enabling the column and row enable inputs, deactivates the bleed transistor and activates the drive transistor to link the actuator to the power supply.

Abstract: A printhead is provided having at least first and second rows of print nozzles. Each nozzle has first circuitry of a first type arranged on an opposite side of the nozzle as second circuitry of a second type. The respective positions of the first and second circuitry of each nozzle of the first row are rotated 180 degrees relative to the respective positions of the first and second circuitry of each nozzle of the second row.