Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: A printhead having at least first and second rows of print nozzles. Each nozzle has first circuitry of a first type arranged asymmetrically to second circuitry of a second type. The respective positions of the first and second circuitry of each nozzle of the first row are arranged mirrored with respect to the first and second circuitry of each nozzle of the second row.

Abstract: An inkjet printer that has a printhead IC an array of nozzles for ejecting drops of printing fluid onto a media substrate and drive circuitry for driving the array of nozzles and, a print engine controller (PEC) for sending print data to the printhead IC. The drive circuitry is configured to extract a clock signal from the data transmission from the PEC.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: An inkjet printer comprising: an array of nozzles arranged into rows, each row of nozzles is divided into a series of groups; and, drive circuitry for sending a drive pulse to each of the nozzles individually such that they eject a drop of printing fluid; wherein, the drive circuitry delays sending the drive pulses to one of the groups relative to at least one of the other groups.

Abstract: The present invention is directed to an excavator that is operable in manual and automatic modes and uses state machines to effect unit operations, rotationally offset swing actuators to rotate boom and cutter head, a fail safe hydraulic system to maintain gripper pressure in the event of a malfunction of the hydraulic system, differing position and pressure control functions in the hydraulic actuators, a kinematic module to effect pitch and roll adjustments, a cutting face profile generator to generate a profile of the excavation face, and an optimization module to realize a high degree of optimization of excavator operation.

Abstract: A printhead controller is provided for supplying dot data to a printhead module having a plurality of nozzles for expelling ink. The printhead module includes a plurality of thermal sensors. Each of the thermal sensors is configured to respond to a temperature at or adjacent at least one of the nozzles. The printhead controller is configured to modify operation of at least some of the nozzles in response to the temperature rising above a first threshold. The printhead module is a thermal inkjet printhead module and each of the nozzles includes a thermal ink ejection mechanism. Each thermal sensor comprises at least part of one of the thermal inkjet mechanisms.

Abstract: A printer controller for controlling a printhead comprising at least one monolithic printhead module, the at least one printhead module having a plurality of rows of nozzles configured to extend, in use, across at least part of a printable pagewidth of the printhead, the nozzles in each row being grouped into at least first and second fire groups, the printhead module being configured to sequentially fire, for each row, the nozzles of each fire group, such that each nozzle in the sequence from each fire group is fired simultaneously with respective corresponding nozzles in the sequence in the other fire groups, wherein the nozzles are fired row by row such that the nozzles of each row are all fired before the nozzles of each subsequent row, wherein the printer controller is configured to provide one or more control signals that control the order of firing of the nozzles.

Abstract: A printer is provided having a printhead having ejection nozzles and a plurality of controllers configured to process print data for printing and to output the processed data to the printhead. The plurality of controllers are connected to a common input of the printhead.

Abstract: A printhead IC is provided having an ejection nozzle, drive circuitry for generating drive signals for driving the ejection nozzle, and a temperature sensor connected to the drive circuitry. The drive circuitry adjusts the drive signals in response to output of the temperature sensor so as to generate the drive signals as print signals and de-clog signals. The de-clog signals have a longer duration than the print signals.

Abstract: A print engine is provided having printhead modules and a controller. Each printhead module has a plurality of ejection nozzles. The nozzles of at least one of the printhead modules is rotationally displaced relative to the other printhead modules. The controller communicates ejection data to the ejection nozzles in accordance with a cumulative correction factor for each printhead module, including printhead modules having non-rotationally displaced nozzles, to at least partially compensate for the rotational displacement.

Abstract: A printer is provided having a carrier, a printhead having a plurality of nozzles, at least one of the nozzles being rotationally displaced relative to the carrier, and a controller for determining and communicating print data to the nozzles. The controller is configured to determine the rotational displacement, determine a correction factor for compensating for a printing error caused by the determined rotational displacement, and alter the print data based on the correction factor to at least partially compensate for the rotational displacement. The correction factor is at least partially based on a thickness of media being printed on.

Abstract: A folder includes a first cylinder having at least one first gripper for holding signatures and at least one tucker for tucking the signatures to define a first fold, a second cylinder having at least one first jaw for holding the signatures at the first fold, a first motor driving the at least one first gripper, and a second motor separate from the first motor, the second motor driving the at least one tucker of the first cylinder and the at least one first jaw of the second cylinder.

Abstract: A printer controller is provided for supplying ejection data to a printhead mounted to a carrier and having a plurality of ejection nozzles. The printer controller is configured to determine a rotational displacement of the printhead relative to the carrier, determine a correction factor at least partially based on a thickness of media being printed on so as to at least partially compensate for the determined rotational displacement, and alter the supply of the ejection data based on the correction factor.

Abstract: A load securing system comprises a tensioning member (18), and a securing member (22) on the tensioning member. First and second containers (12) can be arranged adjacent each other in an array of containers. Each of said first and second containers has a cooperating formation (28) to cooperate with the securing member. The tensioning member can extend across the containers to the aforesaid cooperating formations, and the securing member can be secured to the cooperating formations. The tensioning member can be tensioned to secure the first and second containers to each other.

Abstract: A method, system, and computer program product for detecting and enforcing compliance with access requirements for a computer system in a restricted computer network. A compliance validation configuration file is created for the computer system. A maintenance service utility is configured to launch a compliance validation executable file at a specified time during operation of the computer system. A digital hash is generated for the compliance validation executable file and for the compliance validation configuration file. A determination is made if the computer system or a computer system user is a member of a configured restricted group. If the computer system or the computer system user is a member of a configured restricted group, a determination is made if a directory site code for a subnet of the restricted computer network to which the computer system is connected corresponds to a configured and allowed site.

Abstract: Provided is a print engine pipeline subsystem of a printer controller. The subsystem includes a print engine pipeline controller for reading and writing print engine pipeline registers, and a contone decoder unit for expanding JPEG compressed continuous tone (“contone”) layers. Also included are a lossless bi-level decoder for expanding compressed bi-level layers, a line loader unit for expanding page images for a printhead, and a printhead interface for sending dot data to the printhead and for providing line synchronization between multiple printer controllers.

Abstract: A printhead IC comprising: an array of nozzles; an ejection actuator corresponding to each of the nozzles respectively, the ejection actuator having a resistive heater that is activated when the actuator ejects ink through the corresponding nozzle; drive circuitry for receiving print data and activating the actuators with drive signals in accordance with the print data; and, open actuator test circuitry for selectively disabling the actuators when they receive a drive signal while comparing the resistance of the resistive heater to a predetermined threshold to assess whether the actuator is defective.