Patents by Inventor Mark A. Osborne

Mark A. Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method to detect protein-protein interactions
    Patent number: 5637463
    Abstract: Methods are provided for studying protein-protein interactions which require posttranslational modification of one of the proteins. The interaction is detected by reconstituting the activity of a transcriptional activator. This activity is dependent on the interactions between three different proteins. These include two chimeric proteins, one of which must be posttranslationally modified by the activity of the third protein in order for the chimeric proteins to interact. One of the chimeric proteins contains a transcriptional activation domain fused to a test protein. The second chimeric protein contains a DNA-binding domain of a transcriptional activator fused to the other test protein.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: June 10, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephen Dalton, Jarema P. Kochan, Mark A. Osborne