Abstract: Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity against a variety of infective diseases, where the diseases are caused by pathogens containing a basic amino acid PIP-2 pincer (BAAPP) domain that interacts with phosphatidylinositol 4,5-bisphosphate (PIP-2) to mediate pathogen replication. Also provided are methods of inhibiting a PI4-kinase and methods of inhibiting viral infection. In some embodiments, the compound is a PI4-kinase inhibiting compound that is a 5-aryl-thiazole or a 5-heteroaryl-thiazole. The subject compounds may be formulated or provided to a subject in combination with a second anti-infective agent, e.g. interferon, ribavirin, and the like.

Abstract: Various embodiments of the present technology relate to solutions for gas leak detection in natural gas extraction and storage environments. In some examples, a machine learning interface generates feature vectors based on video data that depicts a natural gas storage facility and feeds the feature vectors to a machine learning engine. The machine learning engine ingests the feature vectors and generates a machine learning output that indicates the presence of the gas leak in the natural gas storage facility. The machine learning interface receives the machine learning output that indicates the presence of a gas leak in the natural gas storage facility. The machine learning interface generates and transfers an alert based on the machine learning output.

Abstract: Delivery systems for liquid embolics and methods of using them are disclosed. The devices generally include a catheter and one or more retention elements to limit migration of the liquid embolic to non-target sites.

Abstract: Binaural hearing systems presented herein are configured to provide a recipient with magnified binaural cues. In certain embodiments, the techniques presented herein use static sideways beamforming with interaural magnification to capture and prepare sound signals for subsequent processing. That is, sound signals are captured at each of the binaural prostheses in accordance with a sideways directional pattern (e.g., directional patterns facing away from the head of the recipient). The sound signals captured with the sideways directional patterns, referred to as sideways directional signals, are then used to perform interaural magnification. In other embodiments, the techniques presented herein use constrained adaptive beamformers to capture sound signals for subsequent processing.

Abstract: The various embodiments described herein relate to systems, methods, and devices associated with distributed ledger systems (e.g., distributed ledger technology implemented on a decentralized network) that can be used to handle and manage the distribution and access of data in a manner that preserves the benefits of distributed ledger technology while enabling the private sharing of data. More specifically, the distributed ledger systems contemplated herein involve distributed ledger technology (DLT)-based data management platforms that can be implemented on nodes of a data management network.

Abstract: An inkjet printer has a print assembly and a print material feed system comprising a first circulation circuit and a second circulation circuit, the first circulation circuit fluidly coupled between the second circulation circuit and the print assembly.

Abstract: An axle assembly having a drop gear set and a countershaft transmission. The drop gear set may operatively connect a rotor of an electric motor to a countershaft. The countershaft transmission may operatively connect the countershaft to a drive pinion. The electric motor and the countershaft transmission may be positioned on opposite sides of a differential assembly.

Abstract: An axle assembly having a differential carrier, a differential assembly, and a lubricant deflector. The differential assembly is mounted to the differential carrier and is rotatable about a differential axis. The lubricant deflector is mounted to the differential carrier and directs lubricant that is splashed or sprayed by a ring gear of the differential assembly into a lubricant passage of the differential carrier.

Abstract: Extended-release microsphere formulations comprising a BTK inhibitor are provided. In one aspect, the microsphere formulations are characterized in that the BTK inhibitor is ibrutinib, and the ibrutinib is released in vivo in humans over a period of from about 7 to about 28 days. Methods for making and using the formulations are also provided.

Abstract: Techniques are provided for implementing a persistent memory storage tier to manage persistent memory of a node. The persistent memory is managed by the persistent memory storage tier at a higher level within a storage operating system storage stack than a level at which a storage file system of the node is managed. The persistent memory storage tier intercepts an operation targeting the storage file system. The persistent memory storage tier retargets the operation from targeting the storage file system to targeting the persistent memory. The operation is transmitted to the persistent memory.

Abstract: A memory module socket, including a first member extending between a first end and a second end of the socket, the second end of the socket opposite to the first end of the socket, the first member positioned along a first side of the socket, the first member including: a plurality of first contact pins, each of the first contact pins including a first contact point and a second contact point; a plurality of first resistive coatings connecting two or more of the first contact pins to define first groupings of contact pins; a plurality of first ribs separating each of the first groupings of first contact pins; wherein when the first contact pins are in a first position, the second contact points of the first contact pins are in contact with respective first resistive coatings to complete a termination to ground.

Abstract: A multi-purpose vehicle includes reconfigurable bumper ends each including a vehicle bumper end body configured to securely attach to a vehicle bumper and extend along a side of a vehicle on which the vehicle bumper is mounted. A socket formed within the vehicle bumper end body is configured to receive an insert portion of a bumper end insert. Bumper end inserts may include a step insert or a safety indicator insert.

Abstract: For use as an accessory with a multi-purpose vehicle having enclosed and rooftop cargo storage, a ladder/ramp includes a pair of siderails and crossbars extending between the siderails. A plurality of panels are each rotatably mounted between the siderails adjacent to one of a plurality of the crossbars, with each panel selectively rotatable between a closed position substantially aligned with the siderails and an open position extending outwardly from the siderails. When the panels are in the closed position, the panels and the crossbars collectively form a substantially continuous surface between the siderails on which wheels can be rolled. When the panels are in the open position, the panels each form a step that may support at least about 250 pounds. The panels may snap into place when moved into the open or closed positions, to prevent inadvertent movement therefrom.

Abstract: Presented herein are techniques for adapting/transitioning operation of a medical prosthesis, such as an auditory prosthesis, from a first or initial group of settings to a second or target group of settings. The adaptation in the operation of the medical prosthesis from the first group of settings to the second group of settings occurs over a period of time and in a series of individualized (recipient-specific) incremental steps. That is, the adaptation process occurs in incremental steps that are set based on attributes/characteristics of the recipient of the specific medical prosthesis so that the adaptation is made as unobtrusive to the recipient as possible.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0099’ particularly distinguished by its small to medium size plant with round plant habit, a medium to large size semi double flower, a yellow flower color with somewhat quilled petals, and a natural season response in mid to late September.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0106’ particularly distinguished by its medium to large size plant with round plant habit, a medium size semi double flower, and a natural season response in mid October. Flowers start as bronze buds and open to rich yellow flower color with bronze flower center.