Abstract: The present invention relates to a compound of the Formula: and pharmaceutically salts thereof. The compound of the present invention inhibits Pol?. This novel therapeutic compound is therefore useful for the treatment and/or prevention of diseases and conditions in which Pol? activity is implicated, such as, for example but not limited to, the treatment and/or prevention of cancer. The present invention also relates to pharmaceutical compositions comprising the novel therapeutic compound defined herein, to processes for synthesising the compound and to their use for the treatment of diseases and/or conditions in which Pol? activity is implicated.

Abstract: A multi-legged equipment support, components thereof, and associated methods. The equipment support comprises a stand and an equipment holder. The stand includes a hub and multiple legs pivotable with respect to the hub. The legs are pivotable outward from stowed positions to preset operational pivoted positions. The user can select a preset operational pivoted position in which outward pivoting of a leg will stop based on moving an actuator between preset locations.

Abstract: Methods, apparatus, devices, subsystems, and systems for holographically displaying three-dimensional objects are provided. In one aspect, an optical device includes: an optical guiding device configured to guide light to propagate along a first direction within the optical guiding device, the light including multiple colors of light; an in-coupling diffractive structure configured to diffract the light to propagate in the optical guiding device; and a plurality of out-coupling diffractive structures arranged downstream of the in-coupling diffractive structure along the first direction and configured to diffract at least part of the light out of the optical guiding device along a second direction different from the first direction. The optical device can be configured for at least one of: color crosstalk suppression among the multiple colors of light, display zero order light suppression, dispersion compensation, or ambient light blocking.

Abstract: A utility vehicle includes a wheeled chassis and a side-dump bed. The wheeled chassis includes a chassis frame extending along a fore-and-aft vehicle axis. The side-dump bed is configured to contain and selectively discharge material toward a dump side of the wheeled chassis. The side-dump bed is shiftably attached to the chassis frame for movement between a lowered condition, in which the side-dump bed extends laterally from the dump side of the wheeled chassis to the other side, and a raised condition, in which the side-dump bed is shifted toward the dump side to discharge material.

Abstract: Closure (1), for sealing of a neck finish (2) of a liquid container, comprising a top deck (3) and an outer skirt (4) extending from the top deck (3) in an axial direction (z) away from the top deck (3). The outer skirt (4) comprises a top section (5) arranged adjacent to the top deck (2) and a bottom section (6) separated from the top section (5) by a gap (7). The top section (5) and the bottom section (6) are interconnected to each other by a hinge (8). The outer skirt (4) comprises an inwardly protruding locking bead (9) extending along an inner surface (10) of the outer skirt (4), wherein the locking bead (9) at at least one location continues across the gap (7).

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: A sealing process includes applying a first reactant to a substrate having a porous structure, the first reactant comprising a chromium (III) precursor and a transition metal precursor and applying a second reactant to the first reactant, the second reactant comprising a rare earth element precursor and an alkaline earth element precursor to form reservoirs of trivalent chromium in pore space of the porous structure, and a physical barrier over the substrate and the reservoirs.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: A method includes: accessing objects, generated by a set of sources, representing attributes of assets, affiliated with a computer network, including a set of endpoint devices and a first application; partitioning the objects into object groups including a first object group representing the first application; aggregating objects in the first object group into a first user container representing the first application during the first time interval; and, in response to selection of the first application at an operator portal: generating a visualization representing a subset of endpoint devices, in the set of endpoint devices, on which the first application is installed during the first time interval based on a set of attributes, exhibited by the first application during the first time interval, contained in the first application container; and rendering the visualization at the operator interface.

Abstract: Provided are compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the antigen expression from a virus, gene or trans-gene expression from a virus, or virus protein expression in cells. Other uses, compositions and methods of using same are also provided.

Abstract: An apparatus comprises a target to rotate about an axis; an excitation coil to carry an excitation signal; and a first sense coil to carry a sense signal induced by the excitation signal. The first sense coil comprises two or more lobes in one or more planes that are perpendicular to the axis. The two or more lobes comprise a first lobe at a first position relative to the axis and a second lobe at a second position relative to the axis. The second position is substantially the same radial distance from the axis as the first position is from the axis. The second position is at an angular distance of ? from the first position, where ?=180°±?/2, and ? is a measurement range for angular-position sensing (e.g., ?=60°) within a range of 50% to 150% of ?.

Abstract: An electro-optic media includes either a plurality of microcapsules in a binder, a polymeric sheet containing sealed microcells, or droplets in a continuous polymeric phase. Each of the microcapsules, microcells, or droplets contain a dispersion that includes a plurality of charged composite particles and a suspending fluid, and the charged particles move through the suspending fluid under the influence of an electric field. The composite particles include one or more types of pigment particles that are at least partially coated with a polymeric material. Each of the binder, polymeric sheet, continuous polymeric phase, the charged composite particles, and the suspending fluid have an index of refraction, and a difference between the index of refraction of the composite particles and at least one of the binder, polymeric sheet, continuous polymeric phase, and solvent is less than or equal to 0.05 at 550 nm.

Abstract: A computer-implemented method for vehicle registration number recognition, the method comprising obtaining a vehicle registration number to be recognised and a plurality of authorised vehicle registration numbers, and comparing the vehicle registration number to be recognised with the plurality of authorised vehicle registration numbers, wherein comparing comprises: identifying the number of characters in common between the vehicle registration number to be recognised and each of the plurality of authorised vehicle registration numbers; determining whether the number of characters in common between the vehicle registration number to be recognised and each authorised vehicle registration number is above a pre-determined threshold but less than all characters; and in the event that the number of characters in common between the vehicle registration number to be recognised and at least one authorised vehicle registration number is above the pre-determined threshold, sending a signal that the vehicle registration

Abstract: Provided herein are compounds, tautomers, or pharmaceutically acceptable salts thereof, having a structure of formula (I): wherein X1, Y, Z1, Z2, (R1)n, (R2)m, and ring A are as described herein. Also provided are pharmaceutical compositions comprising compounds, tautomers, or pharmaceutically acceptable salts having a structure of formula (I). Further provided are a method of inhibiting cyclin dependent kinase 19 (CDK19) a method of treating breast cancer with the disclosed compounds.

Abstract: In some embodiments, a humidification system includes a heater base having a heater plate, a humidification chamber, and circuit. The circuit can include various conduits, including an inspiratory conduit, expiratory conduit, Y-piece, patient conduit, and/or dry conduit. In use, the chamber contains a quantity of liquid. The heater base heats the heater plate, which in turn heats the liquid to a temperature that causes at least some of the liquid to become vapor, thereby humidifying the gases within the chamber. The gas is delivered to the patient via the inspiratory conduit. Various features can help control the system and ensure the patient receives gases having the desired conditions. These features can be used individually or in various combinations and subcombinations both in existing humidification systems and improved systems for respiratory humidification, laparoscopy, and other purposes.

Abstract: Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.

Abstract: An open compute project mounting system. The open compute project mourning system includes an OCP mounting bay, the OCP mounting bay defining a plurality of guide slots; a first OCP card module, the first OCP card module being positioned within the OCP mounting bay via a first pair of the plurality of guide slots; and, a second OCP card module, the second OCP card module being positioned within the OCP mounting bay via a second pair of the plurality of guide slots.

Abstract: Techniques are provided for compacting indirect blocks. For example, an object is represented as a structure including data blocks within which data of the object is stored and indirect blocks including block numbers of where the data blocks are located in storage. Block numbers within a set of indirect blocks are compacted into a compacted indirect block including a base block number, a count of additional block numbers after the base block number in the compacted indirect block, and a pattern of the block numbers in the compacted indirect block. The compacted indirect block is stored into memory for processing access operations to the object. Storing compacted indirect blocks into memory allows for more block numbers to be stored within memory.

Abstract: A new garden type Chrysanthemum plant named ‘CIFZ0110’ particularly distinguished by its medium size plant with round plant habit, a medium size decorative flower with yellow flower color, and a natural season response in early September.