Abstract: The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.

Abstract: The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating S. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.

Abstract: A rotary steerable drilling system that is operable to drill vertical wellbores and automatically maintain a vertical wellbore drilling path. The system includes a control module for operating solenoid valves that control an amount of fluid pressure applied to bias pad piston/cylinders. The control module is operable to determine when the system is deviating from vertical, in what direction the system is deviating, and where the bias pads are in relation to the direction of deviation. Based on these determinations, the control module actuates the requisite bias pads by controlling the amount of fluid pressure applied to the bias pad piston/cylinders to direct the system back to the vertical drilling path.

Abstract: Various systems, processes, and techniques may be used for converting alternating current power to direct current power for an electro-chemical reactor. In certain implementations, a system and a process may include the ability to receive an alternating current power signal, convert the alternating current signal to a direct current signal, and distribute the direct current signal to at least two power conversion modules coupled to a mounting structure. Each power conversion module may be able to convert a portion of the direct current signal to a high-frequency alternating current signal, adjust the voltage of the high-frequency alternating current signal, convert the voltage-adjusted high-frequency alternating current signal to a direct current power signal, and filter the direct current power signal. The system and the process may include the ability to combine the direct current power signals from the modules into an output direct current power signal for an electro-chemical reactor.

Abstract: Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

Abstract: Hammer drills and similar devices have an ongoing dust and debris problem that is solved by a protector device covering the drill in a main body protector shielding a user from the materials. The protector device has an evacuation region on its underside with multi dimensional adapters for attaching hoses of varying sizes. Additionally, an insertable collapsible accordion cylinder assists in covering the debris falling from different size drills being used. A second embodiment has a circular saw dust protector attachment arranged as two half moons or 1/4 moon and 3/4 moon having a central cylinder at their respective tops that are to be held together with a mechanical latch.

Abstract: An endpoint node on a switch fabric announces an intent to host a service for the switch fabric. The announcement includes an announcement entry to an announcement record in a data repository maintained at a designated endpoint node on the switch fabric. The announcement entry includes the endpoint node's preference to take a given role to host the service. The endpoint node queries the announcement record to determine what other endpoint nodes have announced an intent to host the service. Based, at least in part, on the query, the endpoint node determines a role it will take to host the service. The endpoint node updates the announcement record to indicate the role.

Abstract: A rocker arm assembly which has an anti-inversion part that prevents a support pin from inverting and, thus, ensuring proper orientation of the support pin, on which a rocker arm is rotatably mounted, is maintained. The anti-inversion part can be incorporated on the support pin, the inner sleeve or the outer sleeve and/or a combination of the support pin, the inner sleeve and/or the outer sleeve.

Abstract: The rocker arm assembly has an anti-inversion part that prevents a support pin from inverting, ensuring proper orientation of the support pin, on which a rocker arm is rotatably mounted, is maintained. The anti-inversion part can be a washer, a plate, a plug, or a sleeve. The washer, which has a flat face and a curved face, is intended for use with a cylindrical support pin which matches the curved face of the washer. The plate can include various combinations of tabs, flanges, and/or protrusions that extend in different directions. The plug can resemble any desirable shape, and is removed prior to final assembly. The sleeve can be hollow and is removable.

Abstract: A fielding aid for a baseball or softball glove having an insert composed of a vibration dampening material for slowing or impeding the movement of a ball; the insert having an interior portion and exterior portion. In certain aspects, the interior portion has a convex shape that aids in fielding balls.

Abstract: The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating 5*. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.

Abstract: Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

Abstract: A dual host system and method with back to back non-transparent bridges and a proxy packet generating mechanism. The proxy packet generating mechanism enables the hosts to send interrupt generating packets to each other.

Abstract: The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or induces formation of a broadly neutralizing antibody. Using a fibronectin FNfn10 scaffold bearing two or more modified discontinuous loops, scaffolds that recognize broadly neutralizing antibodies in vitro and from patient serum have been identified. These scaffolds should induce an immune response or mobilize germline specificities to initiate their affinity maturation.

Abstract: The invention is a method for enabling digital content to be downloaded to and used on multiple types of computing device by (i) linking user accounts on each device to a “master” user account defined and stored on a remote server; and (ii) managing the user's access to a defined service using his devices via the said master user account; and (iii) allowing the download of digital content to each said device on which the user is permitted to access the said service using a file format which is appropriate for use on each said device type. A user may manage and access the same user account from multiple types of computing devices. Furthermore, the number of device platforms accessible in a similar manner by the user is extensible and the user's information is kept automatically synchronized across all devices.

Abstract: A method for improving the responsiveness of a client application by providing that application with a local database which is a replicated subset of a database held on a remote server.

Abstract: A dual host system and method with back to back non-transparent bridges and a proxy packet generating mechanism. The proxy packet generating mechanism enables the hosts to send interrupt generating packets to each other.

Abstract: In contrast to the traditional approach of defining relationships between data collections using complex groups of cross-reference database tables, the present invention makes use of generic sets to represent relationships between complex collections of interrelated data. The complexity of a database schema can be greatly reduced by representing the relationships between data items as these data sets (sets of data items). These sets of data items may be defined in one or more database tables in a database. This approach provides for much simplified database data management and control. It enables the easy pre- or re-calculation of sets and provides for the easy creation of hierarchical meta-data trees, which are ideal for the targeted delivery of data to the user.

Abstract: A rocker arm assembly which has an anti-inversion part that prevents a support pin from inverting and, thus, ensuring proper orientation of the support pin, on which a rocker arm is rotatably mounted, is maintained. The anti-inversion part can be incorporated on the support pin, the inner sleeve or the outer sleeve and/or a combination of the support pin, the inner sleeve and/or the outer sleeve.