Patents by Inventor Mark A. Tapsak

Mark A. Tapsak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12115357
    Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
    Type: Grant
    Filed: March 16, 2022
    Date of Patent: October 15, 2024
    Assignee: DEXCOM, INC.
    Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv Ullas Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
  • Publication number: 20240269353
    Abstract: Nitric oxide releasing particles, coatings, tapes, monoliths, and sprayable formulations for reducing the normal foreign body response (FBR) to implanted materials, enhancing wound healing, and/or increasing vascularization. The particles, coatings, tapes, monoliths, and sprayable formulations comprise a biodegradable polymer and an NO-releasing donor compound, and/or are formed of a biodegradable polymer with pendant NO-releasing functional groups.
    Type: Application
    Filed: May 23, 2022
    Publication date: August 15, 2024
    Inventors: Mark Tapsak, Alice Widman, Andrew P. Gaudet De Lestard
  • Publication number: 20230139158
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
    Type: Application
    Filed: December 27, 2022
    Publication date: May 4, 2023
    Applicant: DexCom, Inc.
    Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
  • Publication number: 20230138407
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.
    Type: Application
    Filed: December 30, 2022
    Publication date: May 4, 2023
    Applicant: DexCom, Inc.
    Inventors: Jiong Zou, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Shanger Wang
  • Publication number: 20220214300
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.
    Type: Application
    Filed: December 23, 2021
    Publication date: July 7, 2022
    Applicant: DEXCOM, INC.
    Inventors: Shanger Wang, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A. Tapsak, Huashi Zhang, Jiong Zou
  • Publication number: 20220203038
    Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
    Type: Application
    Filed: March 16, 2022
    Publication date: June 30, 2022
    Applicant: DexCom, Inc.
    Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv Ullas Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
  • Publication number: 20220111148
    Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
    Type: Application
    Filed: December 20, 2021
    Publication date: April 14, 2022
    Applicant: DexCom, Inc.
    Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv Ullas Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
  • Patent number: 11262326
    Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: March 1, 2022
    Assignee: DEXCOM, INC.
    Inventors: Shanger Wang, Robert J. Boock, Andrew Trinin Dennis, Ted Tang Lee, Jeff T. Suri, David Sze, Mark A Tapsak, Huashi Zhang, Jiong Zou
  • Patent number: 11246990
    Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 15, 2022
    Assignee: DexCom, Inc.
    Inventors: James H. Brauker, Mark A. Tapsak, Sean T. Saint, Apurv Ullas Kamath, Paul V. Neale, Peter C. Simpson, Michael Robert Mensinger, Dubravka Markovic
  • Publication number: 20210370088
    Abstract: Modulation of foreign body responses in living tissue, and more particularly, devices and related methods for light-based modulation of foreign body responses in living tissue are disclosed. Light sources are disclosed that provide light with characteristics for modulation of foreign body responses that may be elicited by percutaneous and/or subcutaneous devices, including medical devices and other consumer electronic devices. Light delivery structures are disclosed that propagate light from the light sources to irradiate associated subcutaneous tissues. Modulation of foreign body responses may include inhibiting collagen and fibrous tissue generation, modulating inflammation and healing, and/or increasing nitric oxide production and/or release. By modulating foreign body responses associated with percutaneous and/or subcutaneous devices, performance characteristics and lifetimes of such devices may be improved.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 2, 2021
    Inventors: Michael John Bergmann, Mark Tapsak, David T. Emerson, F. Neal Hunter, Andrew P. Gaudet de Lestard
  • Publication number: 20200375515
    Abstract: A biointerface membrane for an implantable device including a nonresorbable solid portion with a plurality of interconnected cavities therein adapted to support tissue ingrowth in vivo, and a bioactive agent incorporated into the biointerface membrane and adapted to modify the tissue response is provided. The bioactive agents can be chosen to induce vascularization and/or prevent barrier cell layer formation in vivo, and are advantageous when used with implantable devices wherein solutes are transported across the device-tissue interface.
    Type: Application
    Filed: August 20, 2020
    Publication date: December 3, 2020
    Inventors: Mark Shults, James H. Brauker, Victoria Carr-Brendel, Mark Tapsak, Dubravka Markovic
  • Publication number: 20200187834
    Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
    Type: Application
    Filed: February 25, 2020
    Publication date: June 18, 2020
    Inventors: James R. Petisce, Mark A. Tapsak, Peter C. Simpson, Victoria Carr-Brendel, James H. Brauker
  • Patent number: 10610140
    Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 7, 2020
    Assignee: DexCom, Inc.
    Inventors: James R. Petisce, Mark A. Tapsak, Peter C. Simpson, Victoria Carr-Brendel, James H. Brauker
  • Publication number: 20190239782
    Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
    Type: Application
    Filed: April 18, 2019
    Publication date: August 8, 2019
    Inventors: Mark C. Shults, Stuart J. Updike, Rathbun K. Rhodes, Barbara J. Gilligan, Mark A. Tapsak
  • Publication number: 20190083018
    Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
    Type: Application
    Filed: November 9, 2018
    Publication date: March 21, 2019
    Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
  • Patent number: 10154807
    Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: December 18, 2018
    Assignee: DexCom, Inc.
    Inventors: Mark A. Tapsak, Rathbun K. Rhodes, Mark C. Shults, Jason D. McClure
  • Publication number: 20180333896
    Abstract: Methods of transforming an ultra-high molecular weight polymer into a processable material and compositions resulting from those methods. The methods may include a combination of applying a shear force to a polymer and heating the polymer. Also described are methods for using the compositions.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 22, 2018
    Inventors: Mark A. Tapsak, Michael Janse, Binay Patel, Philip Brunner
  • Publication number: 20180333897
    Abstract: Methods of transforming an ultra-high molecular weight polymer into a processable material and compositions resulting from those methods. The methods may include a combination of applying a shear force to a polymer and heating the polymer. Also described are methods for using the compositions.
    Type: Application
    Filed: May 25, 2018
    Publication date: November 22, 2018
    Inventors: Mark A. Tapsak, Michael Janse, Binay Patel, Philip Brunner
  • Publication number: 20180317827
    Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
    Type: Application
    Filed: July 5, 2018
    Publication date: November 8, 2018
    Inventors: James H. Brauker, Mark C. Shults, Mark A. Tapsak
  • Publication number: 20180256084
    Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Inventors: James R. Petisce, Mark A. Tapsak, Peter C. Simpson, Victoria Carr-Brendel, James H. Brauker