Abstract: An additive manufactured (AM) metal coupon for a turbomachine component is provided. The component includes an airfoil body having a pressure side, a suction side, a trailing edge, and a coupon opening. The AM metal coupon has an AM metal member with at least one slanted coupon side wall at an angle of less than 90° with an exterior surface of the AM metal member. The AM metal member also has a first porous region having a first porosity and a second porous region having a second porosity different than the first porosity. A braze material couples the AM metal coupon in the coupon opening in the airfoil body and infiltrates into at least one of the first porous region based at least on a characteristic of the first porosity and the second porous region based at least on a characteristic of the second porosity.

Abstract: A component includes a body and an additively manufactured (AM) metal coupon that includes at least one first porous region having a first porosity and may include any number of second porous regions having a second porosity different than the first porosity. A braze material couples the metal coupon in a coupon opening in the body. The braze material infiltrates into at least one of the first porous region based at least on a characteristic of the first porosity or any second porous region based at least on a characteristic of the second porosity. The different porosities can be customized to provide the first porous region and the second porous region with the braze material therein with different physical characteristic(s).

Abstract: The disclosures herein relate to novel compounds of formula (1): and salts thereof, wherein A; X; n; R1 and R2 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with H4 receptors.

Abstract: A method of driver behavior that includes generating, by a mobile device located inside a vehicle, telematics data associated with operation of the vehicle, and transmitting, from the mobile device to one or more processors via wireless communication, the telematics data in real-time. The method also includes analyzing the telematics data to determine whether a driving score for a driver, determining whether the driving score is greater than a threshold value, determining a discount based upon the driving score being higher than the threshold, and generating a communication based upon the discount. The method further includes transmitting the communication.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: The disclosures herein relate to novel compounds of formula (1) and salts thereof, wherein V; W; X; Y; Z; R1; R2; R3; R4 and R5 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

Abstract: The present invention is directed to methods for constructing a flange on a pipe using an additive manufacturing process, such as directed energy deposition, powder bed fusion, friction-stir, or diode laser cladding. The flange can be constructed on a pipe comprising an oxide dispersion strengthen or nickel-based alloys, in particular a precipitation strengthened nickel-based alloy, such that the pipe maintains its inherent mechanical and metallurgical properties, including hardness, tensile strength, yield strength, fracture toughness, creep strength, fatigue, which would otherwise be reduced based upon typical welding of a flange to the end of the pipe. The flange can be constructed around the exterior of a pipe at the end of the pipe to allow use of the flange in connecting the pipe via bolting to other piping components, such as another pipe with a corresponding flange, a valve flange, a pump flange, or any other type of flange.

Abstract: Novel compounds of formula (1): and salts thereof, wherein A; X; n; R1 and R2 are defined herein, are disclosed, as well as their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with H4 receptors.

Abstract: This invention related to compounds having activity as muscarinic M1 or M1 and M4 receptor agonists which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula (I) where X1; X2; X3; X4; Y; Z; n, R1 and R2 are defined herein.

Abstract: A seat may have a seat longitudinal adjustment device having two rail pairs. The rail pairs may each have a lower rail and an upper rail. A contacting device is provided at least for electrically connecting a drive unit and a number of seat components to at least one control unit and to an electrical power supply unit. The contacting device may have at least one plug having a number of contact pins and/or contact elements, and a socket having a number of corresponding mating contact elements. When the plug is inserted into the socket, at least the electrical connection is established between the electrical power supply unit and the at least one control unit and the drive unit for the seat longitudinal adjustment device and the seat components. The contacting device may have at least one positioning element and/or one short-circuit element.

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula where m, p, q, W, Z, Y, X1, X2, R1, R2, R3 and R4 are as defined herein.

Abstract: A cable cassette for a seat longitudinal adjustment apparatus may have at least a housing and two rotatably mounted deflecting rollers. One of the deflecting rollers may be held such that it is guided for longitudinal movement in the housing relative to the other, stationary deflecting roller. A first free end of the connecting cable of the cable bundle is held in a fixed position via a first cassette outlet and the connecting cable or the cable bundle is guided and deflected around the movable deflecting roller and led from the movable deflecting roller to the other, stationary deflecting roller and is deflected around said stationary deflecting roller. A second free end of the connecting cable or of the cable bundle is movably mounted. A seat longitudinal adjustment apparatus may have the cable cassette.

Abstract: The invention relates to a process for producing ethylene carbonate and/or ethylene glycol, which comprises the following steps: a) supplying an overhead absorber stream withdrawn from an absorber to a vapor-liquid separator to yield an aqueous bottoms stream and a recycle gas stream; b) supplying an aqueous process stream comprising one or more impurities to a distillation apparatus to yield an overhead impurities stream and a purified aqueous process stream, wherein the aqueous process stream supplied to the distillation apparatus comprises at least a portion of the aqueous bottoms stream withdrawn from the vapor-liquid separator, wherein the overhead impurities stream is supplied to a condenser and is cooled to a temperature in the range of from 5 to 95° C., wherein the cooled overhead impurities stream is split into a reflux stream which is recycled to the distillation apparatus and an overhead impurities stream; and further steps c) and d).

Abstract: The present invention relates to the engineering an animal model, preferably mammalian models, more preferably a rat model representing Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in a severe, early-onset axonal neuropathy. A model having the p.Arg364Trp Mfn2 mutation is based on a mutation made using zinc finger endonuclease technology in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized behaviorally and shown to develop multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type rats sacrificed at 7, 40, and 48 weeks and analyzed by light microscopy showed a reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.

Abstract: The present invention relates to Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in severe, early-onset axonal neuropathy for p.Arg364Trp Mfn2 mutation in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized with multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type at 7, 40, and 48 weeks showed reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks not present in 7-week-old cohort Mfn2 mutants, or wild type at 7 or 40 weeks. The p.His361Tyr Mfn2 mutation using CRISPR/Cas9 showed abnormalities in gait dynamics at 8 weeks and lengthening of gait cycle at 16 weeks. The invention provides progressive axonal neuropathy for examining pathogenesis and treatment of CMT2A.

Abstract: A mister apparatus includes a portable mister body having an air inlet and an air outlet, a fan configured to draw air in through the air inlet and force the air out the air outlet, a reservoir configured to contain a liquid, the reservoir having a reservoir outlet, a liquid outlet, the liquid outlet being disposed adjacent to or downstream of the air outlet, and a pump in fluid communication with the reservoir. The pump is operable to move the liquid from the reservoir and out of the liquid outlet such that the liquid exiting the liquid outlet enters into the air exiting the air outlet to form a mist.

Abstract: Additive mixtures for nonaqueous battery electrolytes have been discovered that provide for improved performance, and particularly for improved lifetime (cycle life and stability) in high voltage, rechargeable lithium ion batteries. The battery electrolytes comprise less than 10% by weight of an additive mixture comprising an additive solvent, a sulfur containing compound, and lithium difluorophosphate.

Abstract: Light emitting devices and methods for their manufacture are provided. According to one aspect, a light emitting device is provided that comprises a substrate having a recess, and an interlayer dielectric layer located on the substrate. The interlayer dielectric layer may have a first hole and a second hole, the first hole opening over the recess of the substrate. The light emitting device may further include first and second micro LEDs, the first micro LED having a thickness greater than the second micro LED. The first micro LED and the second micro LED may be placed in the first hole and the second hole, respectively.