Abstract: The present invention is directed to methods for constructing a flange on a pipe using an additive manufacturing process, such as directed energy deposition, powder bed fusion, friction-stir, or diode laser cladding. The flange can be constructed on a pipe comprising an oxide dispersion strengthen or nickel-based alloys, in particular a precipitation strengthened nickel-based alloy, such that the pipe maintains its inherent mechanical and metallurgical properties, including hardness, tensile strength, yield strength, fracture toughness, creep strength, fatigue, which would otherwise be reduced based upon typical welding of a flange to the end of the pipe. The flange can be constructed around the exterior of a pipe at the end of the pipe to allow use of the flange in connecting the pipe via bolting to other piping components, such as another pipe with a corresponding flange, a valve flange, a pump flange, or any other type of flange.

Abstract: The invention relates to a process for producing ethylene carbonate and/or ethylene glycol, which comprises the following steps: a) supplying an overhead absorber stream withdrawn from an absorber to a vapor-liquid separator to yield an aqueous bottoms stream and a recycle gas stream; b) supplying an aqueous process stream comprising one or more impurities to a distillation apparatus to yield an overhead impurities stream and a purified aqueous process stream, wherein the aqueous process stream supplied to the distillation apparatus comprises at least a portion of the aqueous bottoms stream withdrawn from the vapor-liquid separator, wherein the overhead impurities stream is supplied to a condenser and is cooled to a temperature in the range of from 5 to 95° C., wherein the cooled overhead impurities stream is split into a reflux stream which is recycled to the distillation apparatus and an overhead impurities stream; and further steps c) and d).

Abstract: The present invention relates to the engineering an animal model, preferably mammalian models, more preferably a rat model representing Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in a severe, early-onset axonal neuropathy. A model having the p.Arg364Trp Mfn2 mutation is based on a mutation made using zinc finger endonuclease technology in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized behaviorally and shown to develop multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type rats sacrificed at 7, 40, and 48 weeks and analyzed by light microscopy showed a reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.

Abstract: Systems and methods for the dynamic selection of IP address in email platforms, and the synchronization of hostnames and IP addresses in such platforms, are disclosed.

Abstract: The present invention relates to Charcot-Marie-Tooth disease 2A (CMT2A) harboring the p.Arg364Trp or p.His361Tyr Mfn2 mutation, whose human counterpart results in severe, early-onset axonal neuropathy for p.Arg364Trp Mfn2 mutation in fertilized rat eggs. Cohorts of mutants and wild type littermates were characterized with multiple motor deficits that worsened over time. Separate cohorts of mutant and wild type at 7, 40, and 48 weeks showed reduced density of myelinated axons and active axonal degeneration in distal but not proximal nerves, as well as axonal degeneration in the fasciculus gracilis of the cervical spinal cord at 40 and 48 weeks not present in 7-week-old cohort Mfn2 mutants, or wild type at 7 or 40 weeks. The p.His361Tyr Mfn2 mutation using CRISPR/Cas9 showed abnormalities in gait dynamics at 8 weeks and lengthening of gait cycle at 16 weeks. The invention provides progressive axonal neuropathy for examining pathogenesis and treatment of CMT2A.

Abstract: A mister apparatus includes a portable mister body having an air inlet and an air outlet, a fan configured to draw air in through the air inlet and force the air out the air outlet, a reservoir configured to contain a liquid, the reservoir having a reservoir outlet, a liquid outlet, the liquid outlet being disposed adjacent to or downstream of the air outlet, and a pump in fluid communication with the reservoir. The pump is operable to move the liquid from the reservoir and out of the liquid outlet such that the liquid exiting the liquid outlet enters into the air exiting the air outlet to form a mist.

Abstract: Additive mixtures for nonaqueous battery electrolytes have been discovered that provide for improved performance, and particularly for improved lifetime (cycle life and stability) in high voltage, rechargeable lithium ion batteries. The battery electrolytes comprise less than 10% by weight of an additive mixture comprising an additive solvent, a sulfur containing compound, and lithium difluorophosphate.

Abstract: Light emitting devices and methods for their manufacture are provided. According to one aspect, a light emitting device is provided that comprises a substrate having a recess, and an interlayer dielectric layer located on the substrate. The interlayer dielectric layer may have a first hole and a second hole, the first hole opening over the recess of the substrate. The light emitting device may further include first and second micro LEDs, the first micro LED having a thickness greater than the second micro LED. The first micro LED and the second micro LED may be placed in the first hole and the second hole, respectively.

Abstract: The invention relates to a process for producing ethylene carbonate and/or ethylene glycol, which comprises the following steps: a) supplying an overhead absorber stream withdrawn from an absorber to a vapor-liquid separator to yield an aqueous bottoms stream and a recycle gas stream; b) supplying an aqueous process stream comprising one or more impurities to a distillation apparatus to yield an overhead impurities stream and a purified aqueous process stream, wherein the aqueous process stream supplied to the distillation apparatus comprises at least a portion of the aqueous bottoms stream withdrawn from the vapor-liquid separator, wherein the overhead impurities stream is supplied to a condenser and is cooled to a temperature in the range of from 5 to 95° C., wherein the cooled overhead impurities stream is split into a reflux stream which is recycled to the distillation apparatus and an overhead impurities stream; and further steps c) and d).

Abstract: Described herein is a device and method for translocating a protein through a nanopore and monitoring electronic changes caused by different amino acids in the protein. The device comprises a nanopore in a membrane, an amplifier for providing a voltage between the cis side and trans side of the membrane, and an NTP driven unfoldase which processed the protein to be translocated. The exemplified unfoldase is the ClpX unfoldase from E. coli.

Abstract: Light emitting devices and methods for their manufacture are provided. According to one aspect, a light emitting device is provided that comprises a substrate having a recess, and an interlayer dielectric layer located on the substrate. The interlayer dielectric layer may have a first hole and a second hole, the first hole opening over the recess of the substrate. The light emitting device may further include first and second micro LEDs, the first micro LED having a thickness greater than the second micro LED. The first micro LED and the second micro LED may be placed in the first hole and the second hole, respectively.

Abstract: Light emitting devices and methods for their manufacture are provided. According to one aspect, a light emitting device is provided that comprises a substrate having a recess, and an interlayer dielectric layer located on the substrate. The interlayer dielectric layer may have a first hole and a second hole, the first hole opening over the recess of the substrate. The light emitting device may further include first and second micro LEDs, the first micro LED having a thickness greater than the second micro LED. The first micro LED and the second micro LED may be placed in the first hole and the second hole, respectively.

Abstract: A mister apparatus includes a portable mister body having an air inlet and an air outlet, a fan configured to draw air in through the air inlet and force the air out the air outlet, a reservoir configured to contain a liquid, the reservoir having a reservoir outlet, a liquid outlet, the liquid outlet being disposed adjacent to or downstream of the air outlet, and a pump in fluid communication with the reservoir. The pump is operable to move the liquid from the reservoir and out of the liquid outlet such that the liquid exiting the liquid outlet enters into the air exiting the air outlet to form a mist.

Abstract: A method is provided for fabricating piezoelectric plates. A sacrificial layer is formed overlying a growth substrate. A template layer, with openings exposing sacrificial layer surfaces, is formed over the sacrificial layer. An adhesion layer/first electrode stack is selectively deposited in the openings overlying the sacrificial layer surfaces, and a piezoelectric material formed in the openings overlying the stack. Then, a second electrode is formed overlying the piezoelectric material. Using the second electrode as a hardmask, the piezoelectric material is etched to form polygon-shaped structures, such as disks, attached to the sacrificial layer surfaces. After removing the template layer and annealing, the polygon-shaped structures are separated from the sacrificial layer. With the proper choice of growth substrate material, the annealing can be performed at a relatively high temperature.

Abstract: Examples of systems are described for calculating a probability of exceeding storage capacity of a virtualized system in a particular time period using probabilistic models. The probabilistic models may advantageously take variances of storage capacity into consideration.

Abstract: A laundry liquid dispensing system comprising (a) a container containing a laundry liquid, said container having an elongate cross section adapted for letterbox delivery wherein the container width is at least twice the container depth and the container depth is less than 5 cm; (b) a dispensing device configured to house the container in a dispensing orientation; (c) a metered dosing device for dispensing, a dose of the laundry liquid from the container via a self-closing aperture, wherein the laundry liquid has a viscosity in the range 200-1500 cps @ 21 s?1.

Abstract: Embodiments are related to systems and methods for fluidic assembly, and more particularly to systems and methods for assuring deposition of elements in relation to a substrate.

Abstract: A fluidic assembly method is provided that uses a counterbore pocket structure. The method is based upon the use of a substrate with a plurality of counterbore pocket structures formed in the top surface, with each counterbore pocket structure having a through-hole to the substrate bottom surface. The method flows an ink with a plurality of objects over the substrate top surface. As noted above, the objects may be micro-objects in the shape of a disk. For example, the substrate may be a transparent substrate and the disks may be light emitting diode (LED) disks. Simultaneously, a suction pressure is created at the substrate bottom surface. In response to the suction pressure from the through-holes, the objects are drawn into the counterbore pocket structures. Also provided is a related fluidic substrate assembly.

Abstract: Rapid knowledge base discovery techniques. A database describes associations between knowledge base articles and closed problem cases. In periodic batch operations, the associations are used to generate solution probability predictors, each of which predictor corresponds to a probability that a particular knowledge base article was used to resolve a particular problem or case. The solution probability predictors comprise probability predictor parameter values associated with the set of words that occur in closed customer problem cases. A specialized data structure is populated with the probability predictor parameter values. When a new active customer problem case is opened, a set of words pertaining to the new, active case is constructed. The active case words are used with the specialized data structure to generate a probability value for each of a set of knowledge base articles. The knowledge base articles having the highest probability values are identified and presented in an ordered list.