Abstract: A component for a vehicle includes a skid plate configured to attach to an underbody of the vehicle, a plurality of cooling channels extending in a longitudinal direction between the skid plate and the underbody of the vehicle, and a structural reinforcement extending outward from the skid plate. The skid plate, the plurality of cooling channels, and the structural reinforcement are additively manufactured in a unitary construction.

Abstract: The present disclosure is related to techniques for converting a natural language utterance to a logical form query and deriving a natural language interpretation of the logical form query. The techniques include accessing a Meaning Resource Language (MRL) query and converting the MRL query into a MRL structure including logical form statements. The converting includes extracting operations and associated attributes from the MRL query and generating the logical form statements from the operations and associated attributes. The techniques further include translating each of the logical form statements into a natural language expression based on a grammar data structure that includes a set of rules for translating logical form statements into corresponding natural language expressions, combining the natural language expressions into a single natural language expression, and providing the single natural language expression as an interpretation of the natural language utterance.

Abstract: A system and method examine positional data signals onboard a vehicle to identify one or more variations in positioning data of the positional data signals. The system and method identify inaccurate positioning data in the positional data signals based on the one or more variations in the positioning data that are identified.

Abstract: A glass transport system configured to mitigate or stop damaging glass leaks by incorporating silica-containing structural components or introducing silica-containing materials to the advancing glass leak flow to cause the molten glass to interact with silica in the silica-containing material and increase the viscosity of the molten glass sufficiently to slowdown or stop the flow of the glass leak.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: An upper of an article of footwear comprises a plurality of stretch zones each having a respective stretching capability. Suitable example stretch zones may include four-way stretch zones, two-way stretch zones, and/or lock-out zones. In some examples, an upper having a plurality of stretch zones comprises a single continuous piece of material configured to have regions of different stretching capability. The single piece of material may comprise a layered material having two stretchable outer layers, wherein a plurality of stretch zones of the piece of material are defined by corresponding intermediate layers disposed at selected locations between the outer layers. Examples of intermediate layers providing two-way stretch, four-way stretch, and little or no stretch are disclosed.

Abstract: A computing resource service provider receives a request from a customer to establish a physical connection between a provider network device and a customer network device in a colocation center. Once the connection has been established, the customer may transmit cryptographic authentication information, through the physical connection, to the provider network device. The provider network device transmits this information to an authentication service operated by the computing resource service provider to verify the authenticity of the information. If the information is authentic, the authentication service may re-configure the provider network device to allow the customer to access one or more services provided by the computing resource service provider. The authentication service may transmit cryptographic authentication information to the customer to verify the identity of the computing resource service provider.

Abstract: Processes and devices provide parenteral delivery of therapeutic fluids, in particular high-viscosity therapeutic fluids (e.g., protein therapeutics), by a chemical reaction that generates a gas. A device may include a first actuation chamber containing a first reagent, a second reaction chamber containing a second reagent, and a third therapeutic fluid chamber containing the therapeutic fluid. In a loaded configuration, a plunger separates the first chamber from the second chamber. In a delivery configuration, the plunger allows the first reagent from the first chamber to communicate and react with the second reagent from the second chamber. The generated gas acts upon a plunger to deliver the therapeutic fluid from the third chamber.

Abstract: A facility for procuring and analyzing information about an anatomical surface feature from a caregiver that is usable to generate an assessment of the surface feature is described. The facility displays information about the surface feature used in the assessment of the surface feature. The facility obtains user input and/or data generated by an image capture device to assess the surface feature or update an existing assessment of the surface feature.

Abstract: An upper of an article of footwear comprises a plurality of stretch zones each having a respective stretching capability. Suitable example stretch zones may include four-way stretch zones, two-way stretch zones, and/or lock-out zones. In some examples, an upper having a plurality of stretch zones comprises a single continuous piece of material configured to have regions of different stretching capability. The single piece of material may comprise a layered material having two stretchable outer layers, wherein a plurality of stretch zones of the piece of material are defined by corresponding intermediate layers disposed at selected locations between the outer layers. Examples of intermediate layers providing two-way stretch, four-way stretch, and little or no stretch are disclosed.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A method for generating and storing secondary content implemented by a content server having a data storage, the method comprising the steps of: storing, in the data storage, one or more pieces of primary content received by the content server, wherein received pieces of primary content are processed to identify a set of one or more feature instances, each feature instance associated with a predefined feature and defining a position within the respective piece of primary content at which said associated feature is present; receiving, from a first client device in data communication with the content server, a search request, the search request specifying one or more search features; determining one or more pieces of primary content for searching in relation to the search request; identifying one or more feature instances in the searched primary content having an associated feature instance corresponding to one or more search features; communicating an instruction to the first client device to display on a user

Abstract: Portable fitness monitoring methods are disclosed. In an embodiment, a portable fitness monitoring method includes a method for providing audible output to a user during an athletic activity using a portable fitness monitoring device. The method includes the steps of receiving an audio feedback file package that includes a first audio feedback file, updating the audio feedback file package, and processing the updated audio feedback file package to provide audible output to the user through an audio output device during the athletic activity.

Abstract: An article of footwear may include an outsole having an opening extending from a top face of the outsole to a ground-contacting face of the outsole, and a traction member disposed within the opening in the outsole. The traction member has a protruding portion and flange portion extending from an upper end of the protruding portion. The flange portion is secured to the top face of the outsole.

Abstract: The instant disclosure provides antibodies that specifically bind to CTLA-4 (e.g., human CTLA-4) and antagonize CTLA-4 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Abstract: A dual-layered midsole for footwear includes an internal midsole layer and an external midsole layer, which are coupled to and separated by a Strobel board. The internal midsole layer may compress and expand with the movement of a wearer of an article of footwear including the dual-layered midsole, while the external midsole may provide stability and cushion for the wearer. Materials selected for the internal and external midsole layers may provide tuned viscoelastic properties to different areas of the midsole as a function of midsole layer thickness at each sole area.

Abstract: An article of footwear may include an outsole having an opening extending from a top face of the outsole to a ground-contacting face of the outsole, and a traction member disposed within the opening in the outsole. The traction member has a protruding portion and flange portion extending from an upper end of the protruding portion. The flange portion is secured to the top face of the outsole.

Abstract: An article of footwear may include an outsole having an opening extending from a top face of the outsole to a ground-contacting face of the outsole, and a traction member disposed within the opening in the outsole. The traction member has a protruding portion and flange portion extending from an upper end of the protruding portion. The flange portion is secured to the top face of the outsole.

Abstract: Portable fitness monitoring methods are disclosed. In an embodiment, a portable fitness monitoring method includes a method for providing audible output to a user during an athletic activity using a portable fitness monitoring device. The method includes the steps of receiving an audio feedback file package that includes a first audio feedback file, updating the audio feedback file package, and processing the updated audio feedback file package to provide audible output to the user through an audio output device during the athletic activity.