Patents by Inventor Mark B. Knudson

Mark B. Knudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200022752
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 23, 2020
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Patent number: 10426545
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: October 1, 2019
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20190184170
    Abstract: A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.
    Type: Application
    Filed: February 26, 2019
    Publication date: June 20, 2019
    Inventors: Mark B. Knudson, Adrianus P. Donders, Timothy R. Conrad
  • Publication number: 20190090946
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: November 20, 2018
    Publication date: March 28, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20190022393
    Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
    Type: Application
    Filed: May 21, 2018
    Publication date: January 24, 2019
    Inventors: Arnold W. Thornton, Dennis Dong-won Kim, Mark B. Knudson, Katherine S. Tweden, Richard R. Wilson
  • Patent number: 9974955
    Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: May 22, 2018
    Assignee: ReShape Lifesciences Inc.
    Inventors: Arnold W. Thornton, Dennis Dong-won Kim, Mark B. Knudson, Katherine S. Tweden, Richard R. Wilson
  • Patent number: 9968778
    Abstract: A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: May 15, 2018
    Assignee: ReShape Lifesciences Inc.
    Inventors: Katherine S. Tweden, Jonathan J. Waataja, Adrianus P. Donders, Mark B. Knudson
  • Publication number: 20170304615
    Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 26, 2017
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 9682233
    Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 20, 2017
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 9616231
    Abstract: A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: April 11, 2017
    Assignee: Enteromedics Inc.
    Inventors: Katherine S. Tweden, Richard R. Wilson, Mark B. Knudson, Dennis Dong-Won Kim, Deepak Bhole
  • Patent number: 9586046
    Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: March 7, 2017
    Assignee: Enteromedics, Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Publication number: 20170021174
    Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
    Type: Application
    Filed: April 14, 2016
    Publication date: January 26, 2017
    Inventors: Arnold W. Thornton, Dennis Dong-won Kim, Mark B. Knudson, Katherine S. Tweden, Richard R. Wilson
  • Publication number: 20160317808
    Abstract: A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 3, 2016
    Inventors: Katherine S. Tweden, Jonathan J. Waataja, Adrianus P. Donders, Mark B. Knudson
  • Publication number: 20160287329
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 6, 2016
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Patent number: 9392971
    Abstract: A method and device for modulating the autonomic nervous system adjacent a pericardial space to treat cardiac arrhythmia includes a treatment source arranged to supply a treatment medium, a catheter having an end sized for insertion into the pericardial space, a medium delivery assembly having a distal end arranged to be positioned by the catheter into the pericardium, with the distal end of the delivery assembly comprising a delivery tip arranged to extend away from the distal end of the catheter into the pericardial space. A connector operatively couples the delivery tip of the medium delivery assembly to the treatment source, and the delivery tip of the medium delivery assembly including a plurality of delivery points for delivering the treatment medium at a plurality of treatment areas within the pericardial space. The device performs modulation or ablation of the autonomic nervous system at selected treatment areas within the pericardium.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: July 19, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Mark B. Knudson
  • Publication number: 20160193465
    Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
    Type: Application
    Filed: November 2, 2015
    Publication date: July 7, 2016
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 9358395
    Abstract: A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: June 7, 2016
    Assignee: EnteroMedics Inc.
    Inventors: Katherine S. Tweden, Jonathan J. Waataja, Adrianus P. Donders, Mark B. Knudson
  • Publication number: 20160144181
    Abstract: A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.
    Type: Application
    Filed: October 23, 2015
    Publication date: May 26, 2016
    Inventors: Mark B. Knudson, Adrianus P. Donders, Timothy R. Conrad
  • Patent number: 9333340
    Abstract: Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: May 10, 2016
    Assignee: EnteroMedics Inc.
    Inventors: Arnold W. Thornton, Dennis Dong-won Kim, Mark B. Knudson, Katherine S. Tweden, Richard R. Wilson
  • Publication number: 20160121120
    Abstract: A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
    Type: Application
    Filed: July 30, 2015
    Publication date: May 5, 2016
    Inventors: Katherine S. Tweden, Richard R. Wilson, Mark B. Knudson, Dennis Dong-Won Kim, Deepak Bhole