Patents by Inventor Mark B. Knudson

Mark B. Knudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8046085
    Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: October 25, 2011
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 8037885
    Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.
    Type: Grant
    Filed: July 12, 2005
    Date of Patent: October 18, 2011
    Assignee: Restore Medical, Inc.
    Inventors: Anja K. Metzger, Brian J. Erickson, John P. Sopp, Mark B. Knudson, Timothy R. Conrad
  • Patent number: 8010204
    Abstract: A system comprising: at least one electrode adapted to be placed on a vagus nerve below a vagal innervation of the heart; an implantable controller comprising an induction coil, at least one circuit for generating a neural conduction blocking signal connected to the at least one electrode, a battery, and a central processing unit comprising program storage and memory; and an external programmer configured to: communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neural conduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively coupl
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: August 30, 2011
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 7986995
    Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: July 26, 2011
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Publication number: 20110034968
    Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
    Type: Application
    Filed: October 20, 2010
    Publication date: February 10, 2011
    Applicant: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Publication number: 20110021968
    Abstract: A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.
    Type: Application
    Filed: October 5, 2010
    Publication date: January 27, 2011
    Applicant: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Patent number: 7844338
    Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: November 30, 2010
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 7833279
    Abstract: A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: November 16, 2010
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Publication number: 20100229876
    Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
    Type: Application
    Filed: March 30, 2010
    Publication date: September 16, 2010
    Applicant: Medtronic Xomed, Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Publication number: 20100204741
    Abstract: A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 12, 2010
    Inventors: Katherine S. Tweden, Richard R. Wilson, Mark B. Knudson, Dennis Dong-Won Kim, Deepak Bhole
  • Publication number: 20100168815
    Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
    Type: Application
    Filed: March 11, 2010
    Publication date: July 1, 2010
    Applicant: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Publication number: 20100137794
    Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
    Type: Application
    Filed: January 29, 2010
    Publication date: June 3, 2010
    Applicant: MEDTRONIC XOMED, INC.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Patent number: 7729771
    Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: June 1, 2010
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 7720540
    Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. In another embodiment, the electrical signal is applied to the vagus nerve transmucosally. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is pancreatitis. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: May 18, 2010
    Assignee: EnteroMedics, Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Publication number: 20100094375
    Abstract: An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
    Type: Application
    Filed: December 15, 2009
    Publication date: April 15, 2010
    Applicant: EnteroMedics Inc.
    Inventors: Adrianus P. Donders, Koen J. Weijand, Mark B. Knudson
  • Patent number: 7693577
    Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: April 6, 2010
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
  • Patent number: 7686021
    Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: March 30, 2010
    Assignee: Medtronic Xomed, Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Patent number: 7669603
    Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: March 2, 2010
    Assignee: Medtronic Xomed, Inc.
    Inventors: Mark B. Knudson, Timothy R. Conrad
  • Patent number: 7672727
    Abstract: An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: March 2, 2010
    Assignee: EnteroMedics Inc.
    Inventors: Adrianus P. Donders, Koen J. Weijand, Mark B. Knudson
  • Patent number: 7630769
    Abstract: Methods and an apparatus are described for treating at least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient. Embodiments include a method for treating a patient having a gastro-intestinal disorder having a inflammatory basis, including positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, and treating the patient's gastro-intestinal disorder by applying an electrical signal to the electrode, wherein the signal has a frequency of at least 500 Hz and is selected to down-regulate neural activity on the vagus nerve, allow partial restoration of nerve activity upon discontinuation of the electrical signal, and wherein the signal is configured to reduce pancreatic output and biliary output. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be blocking or a stimulation signal.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: December 8, 2009
    Assignee: EnteroMedics Inc.
    Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad