Patents by Inventor Mark B. Knudson
Mark B. Knudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8046085Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.Type: GrantFiled: October 20, 2010Date of Patent: October 25, 2011Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 8037885Abstract: A pharyngeal airway having a pharyngeal wall of a patient at least partially surrounding and defining the airway is treated by selecting an implant dimensioned so as to be implanted at or beneath a mucosal layer of the pharyngeal wall and extending transverse to said wall. The implant has mechanical characteristics for the implant, at least in combination with a fibrotic tissue response induced by the implant, to stiffen said pharyngeal wall to resist radial collapse. The implant is implanted into the pharyngeal wall transverse to a longitudinal axis of the airway.Type: GrantFiled: July 12, 2005Date of Patent: October 18, 2011Assignee: Restore Medical, Inc.Inventors: Anja K. Metzger, Brian J. Erickson, John P. Sopp, Mark B. Knudson, Timothy R. Conrad
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Patent number: 8010204Abstract: A system comprising: at least one electrode adapted to be placed on a vagus nerve below a vagal innervation of the heart; an implantable controller comprising an induction coil, at least one circuit for generating a neural conduction blocking signal connected to the at least one electrode, a battery, and a central processing unit comprising program storage and memory; and an external programmer configured to: communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neural conduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output; and an external coil adapted to be worn by the patient, wherein the external coil is connected to the external programmer, and is adapted to inductively couplType: GrantFiled: March 11, 2010Date of Patent: August 30, 2011Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 7986995Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.Type: GrantFiled: January 22, 2007Date of Patent: July 26, 2011Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Publication number: 20110034968Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.Type: ApplicationFiled: October 20, 2010Publication date: February 10, 2011Applicant: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Publication number: 20110021968Abstract: A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.Type: ApplicationFiled: October 5, 2010Publication date: January 27, 2011Applicant: EnteroMedics Inc.Inventors: Mark B. Knudson, Timothy R. Conrad
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Patent number: 7844338Abstract: A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.Type: GrantFiled: June 30, 2004Date of Patent: November 30, 2010Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 7833279Abstract: A method and apparatus for treating a patient's health condition by diverting pancreatic exocrine secretions include a flow diverter of material compatible with chronic residence within a small intestine of the patient. The flow diverter has a cover end and a discharge end. The flow diverter is sized to be placed within the small intestine with the discharge end placed distally from said cover end and with said flow diverter further sized so permit passage of chyme through the small intestine and past the flow diverter. The cover end is sized to cover a discharge papilla of the pancreatic duct. The diverter is adapted to divert at least a portion of pancreatic exocrine secretion from the papilla to the distal discharge end.Type: GrantFiled: November 12, 2004Date of Patent: November 16, 2010Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Timothy R. Conrad
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Publication number: 20100229876Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.Type: ApplicationFiled: March 30, 2010Publication date: September 16, 2010Applicant: Medtronic Xomed, Inc.Inventors: Mark B. Knudson, Timothy R. Conrad
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Publication number: 20100204741Abstract: A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.Type: ApplicationFiled: August 6, 2009Publication date: August 12, 2010Inventors: Katherine S. Tweden, Richard R. Wilson, Mark B. Knudson, Dennis Dong-Won Kim, Deepak Bhole
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Publication number: 20100168815Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.Type: ApplicationFiled: March 11, 2010Publication date: July 1, 2010Applicant: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Publication number: 20100137794Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.Type: ApplicationFiled: January 29, 2010Publication date: June 3, 2010Applicant: MEDTRONIC XOMED, INC.Inventors: Mark B. Knudson, Timothy R. Conrad
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Patent number: 7729771Abstract: At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.Type: GrantFiled: August 13, 2007Date of Patent: June 1, 2010Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 7720540Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. In another embodiment, the electrical signal is applied to the vagus nerve transmucosally. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is pancreatitis. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.Type: GrantFiled: January 22, 2007Date of Patent: May 18, 2010Assignee: EnteroMedics, Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Publication number: 20100094375Abstract: An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.Type: ApplicationFiled: December 15, 2009Publication date: April 15, 2010Applicant: EnteroMedics Inc.Inventors: Adrianus P. Donders, Koen J. Weijand, Mark B. Knudson
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Patent number: 7693577Abstract: At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning a neurostimulator carrier around a body organ of the patient where the organ is innervated by at least a vagal trunk. An electrode is disposed on the carrier and positioned at the vagal trunk. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be a blocking or a stimulation signal.Type: GrantFiled: January 22, 2007Date of Patent: April 6, 2010Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad
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Patent number: 7686021Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.Type: GrantFiled: August 3, 2005Date of Patent: March 30, 2010Assignee: Medtronic Xomed, Inc.Inventors: Mark B. Knudson, Timothy R. Conrad
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Patent number: 7669603Abstract: A patient's pharyngeal wall is treated by inserting an expander member into the airway and positioning an active portion of the expander member in opposition to portions of the pharyngeal wall to be treated. The expander member is activated to urge the wall portions outwardly to an outwardly displaced position. The expander member is then deactivated while leaving the wall portions in the outwardly placed position and the expander member is removed from said airway. A further aspect of the treatment includes stabilization of at least a portion of the pharyngeal wall after compression of portions of the wall.Type: GrantFiled: June 13, 2006Date of Patent: March 2, 2010Assignee: Medtronic Xomed, Inc.Inventors: Mark B. Knudson, Timothy R. Conrad
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Patent number: 7672727Abstract: An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.Type: GrantFiled: August 17, 2005Date of Patent: March 2, 2010Assignee: EnteroMedics Inc.Inventors: Adrianus P. Donders, Koen J. Weijand, Mark B. Knudson
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Patent number: 7630769Abstract: Methods and an apparatus are described for treating at least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient. Embodiments include a method for treating a patient having a gastro-intestinal disorder having a inflammatory basis, including positioning an electrode on a vagus nerve below a vagal innervation of a heart of the patient, and treating the patient's gastro-intestinal disorder by applying an electrical signal to the electrode, wherein the signal has a frequency of at least 500 Hz and is selected to down-regulate neural activity on the vagus nerve, allow partial restoration of nerve activity upon discontinuation of the electrical signal, and wherein the signal is configured to reduce pancreatic output and biliary output. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. The signal may be blocking or a stimulation signal.Type: GrantFiled: January 22, 2007Date of Patent: December 8, 2009Assignee: EnteroMedics Inc.Inventors: Mark B. Knudson, Richard R. Wilson, Katherine S. Tweden, Timothy R. Conrad