Abstract: An oral formulation includes a plurality of agents that promote cellular detoxification. Agents can be included that modulate expression of Nrf2-associated genes upon ingestion of the oral formulation by a subject, wherein the Nrf2-associated genes include at least one gene encoding intrinsic antioxidants, and at least one gene encoding cellular detoxifiers. In addition, at least one of the plurality of agents attenuates inflammation.

Abstract: A system for dispensing a personal care fluid, such as a hand soap or the like. The system includes a dispenser and a refill cartridge. The dispenser includes a dispenser body having a refill cavity and a dispenser lid configured to be coupled to the dispenser body. There may be a pump sub-system mounted to the dispenser lid, or alternatively the personal care fluid may be dispensed by squeezing the dispenser and refill cartridge. The refill cartridge is configured for slidable insertion into and removal from the refill cavity of the dispenser body. The personal care fluid system is designed so that a user can readily and easily change out/replace the refill cartridge for use with a common dispenser, dispenser lid, and pump sub-system.

Abstract: An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece comprises: a first light emitting surface configured to emit light onto a user's maxillary teeth, the first light emitting surface having a concave curvature; a second light emitting surface configured to emit light onto a user's mandibular teeth, the second light emitting surface having a concave curvature; the first and second light emitting surface located on opposite sides of a horizontal reference plane; the first light emitting surface inclined so that a first acute angle is formed between with the first light emitting surface and the horizontal reference plane; and the second light emitting surface inclined so that a second acute angle is formed between with the second light emitting surface and the horizontal reference plane.

Abstract: An oral treatment device that includes a mouthpiece and an electromagnetic radiation source. In one aspect, the oral treatment device includes a mouthpiece comprising a curved wall having a concave inner surface and a bite platform extending from the concave inner surface of the curved wall to a distal end, the distal end of the bite platform extending continuously in a non-interrupted manner from a first end of the bite platform to a second end of the bite platform; an electromagnetic radiation source configured to emit electromagnetic radiation from the curved wall; and wherein the bite platform comprises a collapsible region such that the mouthpiece is alterable between: (1) a biased state in which the curved wall has a first curvature; and (2) a flexed state in which the curved wall has a second curvature that is different than the first curvature.

Abstract: A closure assembly for a dispenser container comprises a base defining a longitudinal recess and a body configured to be moveably coupled to the base. The base comprises a first seal positioned at a first end of the recess and a second seal positioned at an opposing second end of the recess. The body comprises a first body end and an opposing second body end. A shaft extends from the first body end to the second body end. The body is configured to move between an open position where the body is fluidly connected with the recess, and a closed position where the body engages the first seal and the second seal. The first seal and the second seal are configured to exert a force toward each other in a direction along a longitudinal axis of the body to tension the body.

Abstract: A ratchet disc assembly comprises a plurality of stacked ratchet discs defining an interior rising thread path. Each ratchet disc comprises a base and a plurality of thread portions rising from the base. Each of the plurality of thread portions is separated from each other by a slot and an inner surface of each thread portion is threaded to form a section of the rising thread path.

Abstract: A deodorant applicator includes a housing, a screw with a threaded shaft, and an elevator assembly. The elevator assembly includes a receptacle and a threaded portion formed by a plurality of segments or ratchet discs. The ratchet discs can each be slid or pushed onto the screw to form a stack. The receptacle is slid over the stack of ratchet discs so that the stack of ratchet discs forms a threaded portion of the elevator assembly.

Abstract: An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece comprises a lamp support structure comprising a lamp support surface and is formed of a first material. A flexible lamp is mounted to the lamp support surface so that a light emitting surface of the flexible lamp assumes a concave curvature, thereby forming a lamp assembly. A guard component is overmolded to the lamp assembly. In one embodiment, the oral treatment device may be a teeth whitening device.

Abstract: An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece. The mouthpiece comprises a lamp support structure comprising a lamp support surface and is formed of a first material. A flexible lamp is mounted to the lamp support surface so that a light emitting surface of the flexible lamp assumes a concave curvature, thereby forming a lamp assembly. A guard component is overmolded to the lamp assembly. The guard component is formed of an elastomeric material having a hardness that is less than a hardness of the first material. In one embodiment, the oral treatment device may be a teeth whitening device.

Abstract: A system for dispensing a personal care fluid, such as a hand soap or the like. The system includes a dispenser and a refill cartridge. The dispenser includes a dispenser body having a refill cavity and a dispenser lid configured to be coupled to the dispenser body. There may be a pump sub-system mounted to the dispenser lid, or alternatively the personal care fluid may be dispensed by squeezing the dispenser and refill cartridge. The refill cartridge is configured for slidable insertion into and removal from the refill cavity of the dispenser body. The personal care fluid system is designed so that a user can readily and easily change out/replace the refill cartridge for use with a common dispenser, dispenser lid, and pump sub-system.

Abstract: Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.

Abstract: Techniques for multiple-stage crash reporting are described herein. In particular, in some cases, a first stage may include reporting of crash metadata. Also, in some cases, a second stage may include reporting of crash artifact data, such as a crash dump file, error logs, server logs, client logs and/or other data. The crash artifact data may, in some examples, be provided after the crash metadata. By employing multiple stages for reporting of crash-related information, the time required to notify and provide at least some crash-related information to users may be reduced, without requiring the omission of any desired reporting information. Additionally, the use of multiple stages may help to ensure that a notification of the occurrence of the crash and associated metadata are consistently reported, even when crash artifact data uploads fail.

Abstract: Systems and methods of weight management and compositions or formulations useful therein are disclosed and described.

Abstract: An oral formulation includes a plurality of agents that promote cellular detoxification. Agents can be included that modulate expression of Nrf2-associated genes upon ingestion of the oral formulation by a subject, wherein the Nrf2-associated genes include at least one gene encoding intrinsic antioxidants, and at least one gene encoding cellular detoxifiers. In addition, at least one of the plurality of agents attenuates inflammation.

Abstract: An oral treatment device that emits light onto surfaces of a user's teeth. In one aspect, the oral treatment device includes an intraoral mouthpiece comprising: a lamp support surface; and a lamp. When the lamp is mounted to the lamp support surface, a first contact surface of the lamp contacts a first contact surface of a first electrical contact element of the lamp support surface; and (2) a second contact surface of the lamp contacts a second contact surface of a second electrical contact element of the lamp support surface.

Abstract: An oral formulation can include an omega-3 fatty acid, a stilbenoid, a flavonoid, and vitamin D, each present in an amount and weight ratio that causes the formulation to mimic a gene expression profile of caloric restriction in a tissue of a subject, when administered to the subject in a therapeutically effective amount. The oral formulation can also be used in a method of mimicking a caloric restriction gene expression profile in a tissue of a subject.