Abstract: The present invention relates to methods and compositions utilizing inteins to generated libraries of cyclic peptides in vivo.

Abstract: Inflowing data is summarized in real time. The summarized data is displayed as a graph in real time. A portion of the graph is selected using dual sliders. And data that was summarized in real time and represented by the selected graph portion is operated on. Operating on the data that was summarized in real time and represented by the selected graph portion involves displaying components of the data that was summarized in real time and represented by the selected graph portion and/or exporting the data that was summarized in real time and represented by the selected graph portion. Displaying components of the data that was summarized in real time and represented by the selected graph portion involves displaying components of the data that was summarized in real time in one or more new graphs and/or displaying components of the data that was summarized in real time in tabular form.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize an adenosine kinase as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.

Abstract: A tube fitting for a tube end has a female threaded member that cooperates with a male threaded member. The female member includes a tube gripping device in the form of a gripping ring or ferrule that is attached to the female member by a frangible web. Upon a partial pull-up the ferrule engages a camming surface on the male threaded member and breaks off or separates from the female threaded member to become a separate piece so that the fitting then functions as a single ferrule tube fitting. Additional features include a steep camming angle on the camming surface to cause the ferrule to grip the tube end with a bite-type action and to form a primary seal between the camming surface and a front end of the separated ferrule. The ferrule front end, and optionally the entire female threaded member including the initially integral tube gripping device, are hardened to be at least about 3.3 times harder than the material of the tube end.

Abstract: The present application provides peptides that serve as substrates for proteasome enzymatic activity, e.g., the enzymatic activity of Rpn11, a metalloprotease of the 19S regulatory particle. The present application also provides methods and compositions employing the peptide substrates.

Abstract: The invention relates to the inhibition of tubulin polymerization. The invention provides compounds and methods for inhibiting tubulin polymerization. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Abstract: A brake valve actuator (BVA) of a vehicle is controlled by an electronic control unit (ECU) to provide automatic traction control (ATC), roll stability (RS) and yaw stability (YS) functions for the vehicle, by actuating the dual brake valve without driver intervention. The ATC function is provided by making braking pressure available at the driven wheels only of the vehicle. This may be done by selectively controlling the modulators for the driven wheels and the non-driven wheels of the vehicle. The ATC function in this manner can be provided for a straight truck or bus, or for a tractor and trailer, without the need for an ATC solenoid. In another embodiment, a yaw control function is provided, without the need for ATC solenoids or for pressure sensors in the delivery lines. In yet another embodiment, yaw control benefits are provided with an additional sensor.

Abstract: A tone ring preferably for use in a braking system of a vehicle has a first pattern of excitation indicative of speed of rotation of the tone ring, and a second pattern of excitation including frequency variations that is indicative of direction of rotation of the tone ring. The tone ring is rotated past a sensor, preferably a 2-wire passive sensor. A series of events are sensed during rotation of the tone ring past the sensor. The timing of occurrence of the events is detected and, on the basis of the timing detection, the direction of rotation of the tone ring is determined.

Abstract: A tube fitting for a tube end has a female threaded member that cooperates with a male threaded member. The female member includes a tube gripping device in the form of a gripping ring or ferrule that is attached to the female member by a fungible web. Upon a partial pull-up the female engages a camming surface on the male threaded member and breaks off or separates from the female threaded member to become a separate piece so that the fitting then functions as a single ferrule tube fitting. Additional features include a steep camming angle on the camming surface to cause the ferrule to grip the tube end with a bite-type action and to form a primary seal between the camming surface and a front end of the separated ferrule. The ferrule front end, and optionally the entire female threaded member including the initially integral tube gripping device, are hardened to be at least about 3.3 times harder than the material of the tube end.

Abstract: Improved regimens for administering proteasome inhibitors are described, wherein proteasome inhibition is more sustained relative to certain current regimens which permit substantial recovery of proteasome activity between doses of inhibitor.

Abstract: A laryngoscope (10) to assist tracheal intubation on a patient, comprising a body having a handle (14), and a laryngoscope blade (12) extending from the handle (14); a lighting system (21) including a light source integrated in the laryngoscope body and arranged in use to be activated to adopt an operational mode to provide illumination to the patient's throat; control means operative to allow only a single occurrence of the lighting system in the operational mode; and wherein once activated in the operational mode, the lighting system provides illumination for only a limited time.

Abstract: A tube fitting for a tube end has a female threaded member that cooperates with a male threaded member. The female member includes a tube gripping device in the form of a gripping ring or ferrule that is attached to the female member by a frangible web. Upon a partial pull-up the ferrule engages a camming surface on the male threaded member and breaks off or separates from the female threaded member to become a separate piece so that the fitting then functions as a single ferrule tube fitting. Additional features include a steep camming angle on the camming surface to cause the ferrule to grip the tube end with a bite-type action and to form a primary seal between the camming surface and a front end of the separated ferrule. The ferrule front end, and optionally the entire female threaded member including the initially integral tube gripping device, are hardened to have a hardness ratio that is at least about 3.3 times the hardness of the material of the tube end on the Vickers scale.

Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus, such as a detectable label. Along with therapeutic utilities, these peptide based compounds can be used in assays useful for screening, monitoring, diagnostic and/or dosing purposes.

Abstract: The invention is a tool to improve sales force effectiveness. The tool includes an assessment, and analyzing the assessment according to defined dependencies. The organization addresses the issues presented by the assessment according to the dependencies.

Abstract: A submersible electromagnetic (EM) field generator for seafloor electromagnetic surveying comprising an AC to DC converter operable to generate a DC output from an AC input and a switching module operable to generate a waveform driving signal by selectively switching the DC output. The EM field generator also comprises an antenna that is operable to generate an EM field in response to the waveform driving signal. This design approach of using a switched DC source allows square or rectangular wave EM signals to be generated which have sharp transition characteristics and which are substantially independent of the AC input characteristics.

Abstract: The present invention relates to methods and compositions utilizing inteins to generate libraries of cyclic peptides in vivo. The prevent invention also relates to methods for inhibiting protein-protein interaction.

Abstract: A system and method for automatically determining a seed vigor index for a lot of seeds by analysis of a scanned image of a plurality of seedlings grown from lot of seeds, including automatically separating and analyzing overlapped seedlings. According to one aspect of the current invention, seedling analysis software is used to analyze an image of seedlings. The seedling analysis software preferably analyzes both hypocotyl and radicle lengths and thus determines the separation point between the two for each seedling. The seedling analysis software also preferably separates overlapped seedlings, preferably using a simulated annealing technique. According to another aspect of the present invention, a low-cost scanner placed in an inverted configuration in a scanner enclosure is used to generate high-quality, reproducible images of seedlings. According to yet another aspect of the present invention, a method of using ordinary germination boxes, i.e.

Abstract: A fitting for a tube or pipe capable of functioning a high pressures having a first fitting component adapted to receive the conduit end; a conduit gripping device such as a ferrule or ferrules and a second fitting component that can be joined to the first fitting component to cause the conduit gripping device to grip the conduit and seal when assembled. In one aspect of the invention, the first fitting component is constructed from a material that is softer than the material used to construct the second fitting component. An additional aspect of the invention include a retaining portion on the second fitting component that constrains the tube gripping device against pressure. The retaining portion can also be configured to retain the tube gripping device to the second fitting component prior to installation and in a finger-tight condition.

Abstract: A brake valve actuator (BVA) of a vehicle is controlled by an electronic control unit (ECU) to provide automatic traction control (ATC), roll stability (RS) and yaw stability (YS) functions for the vehicle, by actuating the dual brake valve without driver intervention. The ATC function is provided by making braking pressure available at the driven wheels only of the vehicle. This may be done by selectively controlling the modulators for the driven wheels and the non-driven wheels of the vehicle. The ATC function in this manner can be provided for a straight truck or bus, or for a tractor and trailer, without the need for an ATC solenoid. In another embodiment, a yaw control function is provided, without the need for ATC solenoids or for pressure sensors in the delivery lines. In yet another embodiment, yaw control benefits are provided with an additional sensor.

Abstract: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.