Abstract: Flange for a vacuum apparatus comprises a housing to be connected to the vacuum apparatus defining an opening wherein the opening has rectangular narrow shape. The flange further comprises a metal seal arranged around the opening to create a vacuum tight seal.

Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.

Abstract: A computing network comprising a computing service provider and an edge computing network is managed. A trusted device establishes a root of trust at the edge computing network via a trusted component on the trusted device. In response to receiving a first indication of a disconnection or degradation of communications between the computing service provider and the edge computing network, the edge computing network initiates an autonomous mode at the edge computing network. While the edge computing network is operating in the autonomous mode, the trusted device detects new devices that are attempting to access computing resources in the edge computing network. The trusted device stores data pertaining to new devices that were not authorized to access the computing resources in the edge computing network.

Abstract: Connectors and methods for contactless transfer of fluid between containers are disclosed. According to an aspect, a connector includes a body that defines a first end, a second end, and a passageway that extends between the first end and the second end, wherein the first end and second end are configured to attach to a first container and a second container, respectively. The passageway provides a pathway between the first and second containers when the first and second containers are attached to the first and second ends, respectively. Further, the connector includes an opener configured to engage and open the first container for release of a fluid from within the first container through the passageway and into the second container when the first and second containers are attached to the first and second ends, respectively.

Abstract: This invention, in embodiments, relates to a roofing system that includes a roof deck, a plurality of tapered insulation panels applied onto the roof deck, at least one non-tapered insulation panel applied onto the plurality of tapered insulation panels, and a membrane layer applied onto the at least one non-tapered insulation panel. This invention, in embodiments, further relates to a roof assembly kit that includes a plurality of tapered insulation panels and instructions for installation, as well as a method of installing such a roofing system.

Abstract: The present disclosure relates to systems, methods, and computer readable media for facilitating placement of network functions based on a network slice profile that is received and based on internal knowledge of a cloud computing system having network resources thereon. The systems described herein involve tagging the network resources with various characteristics, generating resource management profiles including instructions that may be used to supplement information from the slice profile(s), and matching an incoming slice profile with a resource management profile. The systems described herein facilitate rolling out a deployment of network functions on the network resources in accordance with information from the resource management profile in a way that optimizes resources and allows automated placement of network functions based on a received network slice.

Abstract: The present disclosure relates to systems, methods, and computer readable media for receiving and processing a request to deploy network functions across one or more deployment areas of a telecommunications network. Systems described herein process a request by applying a hierarchical configuration model including a hierarchy of configuration management instructions that can be applied to a request that complies with a format of the hierarchical configuration model. Features described herein facilitate deployment of unique configuration instructions across multiple network functions and across multiple deployment areas based on a single request and without further user interaction with respect to each of multiple network functions.

Abstract: The present disclosure relates to a network function configuration system that efficiently, accurately, and flexibly manages network function configurations in a cloud computing system for a 5G (and beyond) telecommunications network. For example, the network function configuration system utilizes configuration snapshots to perform batches of configuration updates atomically to network functions of a mobile packet core that is implemented in a cloud computing system. To illustrate, in a cloud computing system (such as a core network), network functions run in a current state. To modify the configuration snapshot to a desired state, numerous network function configuration changes must often be applied.

Abstract: This invention relates to an oligonucleotide comprising one or more 2?-modified nucleosides, wherein the 2?-position of the nucleoside has a structure of formula (I). The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein.

Abstract: A medical device inspection scope may include a cylindrical outer layer having a diameter of less than 2 millimeters or even less than 1 millimeter, a cylindrical inner layer disposed concentrically within the outer layer, a circumferential space between the outer layer and the inner layer, and an inner lumen formed by the inner layer. The scope also includes multiple light transmitting fibers disposed in the circumferential space and a camera module disposed in the inner lumen. The light fibers may be designed to transmit illumination light and ultraviolet light. The scope may also optionally include a stiffening member.

Abstract: This invention, in embodiments, relates to a roofing drip edge device that includes a drip edge comprising (i) an upper drip edge that is configured to be installed along an edge of a roofing surface, and (ii) a lower drip edge that is approximately at a right angle to the upper drip edge, a flashing strip member that is secured to the upper drip edge of the drip edge, such that a portion of the flashing strip member overhangs a first side edge of the drip edge, and a connecting member that is secured to the drip edge, such that a portion of the connecting member overhangs a second side edge of the drip edge. This invention, in embodiments, further relates to a method of installing a roofing drip edge device.

Abstract: The present application provides an aft plate removal tool for servicing a combustor. The combustor includes an aft plate with a central passage and a number of tubes extending through the aft plate. The aft plate removal tool includes a central screw, a lower housing attached to the central screw, the lower housing including a number of spring loaded lower housing feet, and an upper housing attached to the center screw, the upper housing including a number of spring loaded upper housing feet. The aft plate removal tool is inserted through the central passage of the aft plate such that rotation of the upper housing advances the spring loaded upper housing feet against the aft plate until the spring loaded upper housing feet push the aft plate off of the tubes.

Abstract: Various techniques to quickly image one or more edge regions of a substrate panel without imaging other regions of the substrate panel, such as areas of the substrate panel that have already been exposed to ultraviolet (UV) light. In some examples, an illumination mask assembly can be coupled to a clamp assembly and used to image at least one edge region of the substrate panel, such as an edge region including one or more dummy patterns. For example, the substrate panel can be clamped using the clamp assembly in order to immerse the substrate panel into a plating bath. Before immersion, the illumination mask assembly can image one or more edge regions of the substrate panel, such as to image the various dummy patterns in a layer of the substrate panel.

Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25. In particular, the present disclosure provides sequences of anti-human CD25 antibodies, which do not block the binding of CD25 to IL-2 or IL-2 signalling. Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical composition and methods of treatment, in particular for treating cancer.

Abstract: Methods and systems of managing dynamic response to wind in a solar tracker system are provided. The method includes determining a wind speed, comparing the wind speed to a predetermined threshold value to determine if the wind speed equals or exceeds the predetermined threshold, positioning a windward most solar tracker to a predetermined angle based on the comparing, and positioning a leeward most solar tracker to the predetermined angle based on the comparing. The solar trackers are positioned at the predetermined angle at a predetermined interval starting at the windward most solar tracker and the remaining solar trackers remain in a normal operating condition.

Abstract: The present invention provides a system and method for capturing images during review of a microscope slide. In certain embodiments, such system and method allow for the capture of images and construction of a composited microscope mosaic image within the workflow of the slide reviewer, such as a pathologist reviewing a tissue sample. In certain embodiments, said mosaic images are whole slide images constructed by and capable of being viewed at variable resolutions and magnifications corresponding to the review of the original microscope slide by the slide reviewer.

Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.

Abstract: This invention, in embodiments, relates to a roofing drip edge device that includes a drip edge comprising (i) an upper drip edge that is configured to be installed along an edge of a roofing surface, and (ii) a lower drip edge that is approximately at a right angle to the upper drip edge, a flashing strip member that is secured to the upper drip edge of the drip edge, such that a portion of the flashing strip member overhangs a first side edge of the drip edge, and a connecting member that is secured to the drip edge, such that a portion of the connecting member overhangs a second side edge of the drip edge. This invention, in embodiments, further relates to a method of installing a roofing drip edge device.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a Filamin A (FLNA) gene, as well as methods of inhibiting expression of an FLNA gene and methods of treating subjects having an FLNA-associated N disease or disorder, e.g., Alzheimer's disease, using such dsRNAi agents and compositions.