Patents by Inventor Mark Brown

Mark Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11519899
    Abstract: A method of diagnosing central nervous system injuries such as acquired brain injury (ABI) and/or acquired spinal cord injury (ASI), including mild TBI (concussion or blast wave), mild ASI (contusion, stretch or partial cord transection), non-TBI brain injury and/or non-TSI spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix; and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of CNS injuries and a predetermined set of profiles of controls to determine if the subject has a CNS injury.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 6, 2022
    Assignee: LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
    Inventors: Douglas Dale Fraser, Robert Bartha, Arthur Brown, Tanya Charyk Stewart, Mark Daley, Gregory A. Dekaban, Timothy Doherty, Lisa Fischer, Jeffrey Holmes, Ravi Menon, J. Kevin Shoemaker, Charles A. Rupar
  • Publication number: 20220382596
    Abstract: Techniques are disclosed for providing method for providing an event timer for event synchronization across Kubernetes clusters. The event timer is configured to provide event synchronization on behalf of microservice instances in the cloud computing environment. In response to a request for an event timer for a timed event, it is determined whether the requested event timer has been started for a second microservice instance. If the requested event timer has been started, a state of the requested event timer is sent to the first microservice instance If the requested event timer has not been started, the requested event timer is instantiated, and a state of the instantiated event timer is stored in a database. The instantiated event timer is independent of the first and second microservice instances. In response to an expiration of the event timer, a single callback for processing of the event is generated.
    Type: Application
    Filed: August 30, 2021
    Publication date: December 1, 2022
    Inventors: Kunal Anand EKAWDE, Abhay BALAPPANAVAR, Michael Anthony BROWN, Ronald Mark PARKER, Anupama RAGHAVAN, Dhananjaya EADALA, Rama Krishna Prasad MANGALAPARTHI, Mark Gordon LIBBY
  • Publication number: 20220380007
    Abstract: A boat lift controller may include a digital switch, a power-isolation relay, and a motor-direction-select relay, together which control a motor. The digital switch may provide power to the power-isolation relay. The power-isolation relay may provide power to the motor-direction-select relay and to the motor. The motor-direction-select relay may control the direction in which the shaft of the motor turns.
    Type: Application
    Filed: May 18, 2022
    Publication date: December 1, 2022
    Inventors: Matt Brown, Dustin Smith, Paul Berkemeier, Mark Austin
  • Publication number: 20220372896
    Abstract: An electrically-actuated variable camshaft timing (VCT) phaser assembly, comprises a sun gear configured to receive input from an electric motor and one or more planet gears having radially-outwardly-extending gear teeth that engage the sun gear; a first ring gear, having radially-inwardly extending gear teeth that engage the radially-outwardly-extending gear teeth of the sun gear, configured to receive rotational output provided by a crankshaft; a second ring gear, having radially-inwardly extending gear teeth that engage the radially-outwardly-extending gear teeth of the sun gear, configured to couple to a camshaft; one or more planet gear pins that carry the planet gear(s) and engage a planetary gear set to prevent the relative rotation of the planet gear pin(s) relative to the planetary gear set; and one or more springs that bias the planet gear pin(s) and the planetary gear(s) toward the first ring gear and the second ring gear.
    Type: Application
    Filed: May 18, 2021
    Publication date: November 24, 2022
    Inventors: Chad McCloy, Daniel Brown, Mark Wigsten
  • Patent number: 11504391
    Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The antisense strand of the dsRNA molecule comprises at least one thermally destabilizing nucleotide occurring at a seed region; the dsRNA comprises at least four 2?-fluoro modifications, and the sense strand of the dsRNA molecule comprises ligand, wherein the ligand is an ASGPR ligand. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA molecules suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA molecules, e.g., for the treatment of various disease conditions.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: November 22, 2022
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Mark K. Schlegel, Maja Janas, Vasant R. Jadhav, Donald Foster, Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, Alexander V. Kel'in, Shigeo Matsuda, Klaus Charisse, Jayaprakash K. Nair, Martin A. Maier, Alfica Sehgal, Christopher Brown, Christopher Theile, Stuart Milstein
  • Patent number: 11510054
    Abstract: Various embodiments of the present disclosure are directed to providing authentication of access while reducing user input and, specifically to a method, apparatus, and computer program product for receiving device identification information from both a secured system indicating devices with authorization and from a third party telecommunications carrier indicating the mobile device account attempting to access a service provider. Embodiments provided include an apparatus configured to receive, from a mobile device, identification information associated with the mobile device. The apparatus further comprises computing an encrypted hash of the identification information and initiating a search of a registry for a matching entry that matches the encrypted hash of the identification.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: November 22, 2022
    Assignee: Averon US, Inc.
    Inventors: Wendell Brown, Mark Klein, Tom Green
  • Patent number: 11498165
    Abstract: Treatment of aneurysms can be improved by delivering an occlusive member (e.g., an expandable braid) to an aneurysm sac in conjunction with an embolic element (e.g., coils, embolic material). A delivery system for such treatment can include an occlusive member configured to be positioned within an aneurysm sac and having a proximal hub. An elongate tubular member has an engagement member removably coupled to the proximal hub, for example via threaded engagement or an interference fit via one or more engagement members. A conduit extending within or adjacent to the elongated member is configured to receive an embolic element therethrough for delivery to the aneurysm sac.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: November 15, 2022
    Assignee: COVIDIEN LP
    Inventors: Gopan Patel, Mark Ashby, Kenneth Brown, Erik Skillrud, Junwei Li
  • Patent number: 11499213
    Abstract: Systems and methods of threading a metal substrate on a rolling mill include receiving a coil of the metal substrate. The method also includes uncoiling the metal substrate from the coil while the coil and guiding the metal substrate to a work stand of the rolling mill with a threading system.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: November 15, 2022
    Assignee: Novelis Inc.
    Inventors: Andrew James Hobbis, Antoine Jean Willy Pralong, Stephen Lee Mick, Rodger Brown, Mark Finn, Peter Knelsen, Terry Lee, Hansjuerg Alder, William Beck, Roberto Quintal, Natasha Iyer, Jeffrey Edward Geho
  • Patent number: 11500478
    Abstract: A method includes determining a physical location of each of a plurality of peripheral devices communicatively coupled to a host computing device, the each of the plurality of peripheral devices including a computer mouse; generating a lighting sequence configured to activate visual output elements on the each of the plurality of peripheral devices; and modifying the lighting sequence based on the physical location of the computer mouse relative to at least one of the other plurality of peripheral devices. In some aspects, the plurality of peripheral devices further includes a mouse pad, and modifying the lighting sequence for the computer mouse is based on the location of the computer mouse relative to its position on the mouse pad. In some cases, modifying the lighting sequence for the computer mouse is based on the location of the computer mouse relative to its position to the other plurality of peripheral devices.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: November 15, 2022
    Assignee: Logitech Europe S.A.
    Inventors: Mark Starrett, Jacob Kottage, Andrew Durrer, Andrew Coonrad, Curtis Brown
  • Publication number: 20220359177
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 10, 2022
    Applicant: Micromass UK Limited
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Publication number: 20220356012
    Abstract: A computer-managed database of interconnected, unique codes attached on trash, recycling and other material management or recovery bags enables program managers to track and measure the materials management behavior including but not limited to weight, composition, compliance, and fraud; and to provide feedback including education, penalties or incentives directly to affected persons in order to cost effectively meet federal, state, local or corporate goals,
    Type: Application
    Filed: May 9, 2022
    Publication date: November 10, 2022
    Inventors: Kristen Brown, Mark Dancy, Steve Lisauskas
  • Publication number: 20220347824
    Abstract: Portable, hand held, battery operated, hydraulic tools are provided with a tool frame and one or more interchangeable working heads. When the working head is connected with the tool frame, a piston actuated by a hydraulic system within the tool frame applies force to the working head to perform a task. A coupling mechanism holds the working head to the tool frame. The coupling mechanism allows the working head to be removed from the tool frame and another working head to be joined to the tool frame. The coupling mechanism can hold the working head at a fixed rotational angle with respect to the tool frame. The coupling mechanism can also allow the working head to rotate with respect to the tool frame.
    Type: Application
    Filed: July 19, 2022
    Publication date: November 3, 2022
    Inventors: John David Lefavour, Thomas Romeo Faucher, Lawrence Brown, Peter Matthew Wason, Bernard P. Vachon, Sarah LaPerriere, Mark A. Chiasson
  • Publication number: 20220351214
    Abstract: A system and method for tiered pricing for any scarce commodity, such as petroleum products or food stuffs, may be used to ration the scarce commodity. The system and method may use a dual currency transaction system to manage the rationing. In the use case for gas or oil as the scarce commodity, the dual currency system and method and the tiered pricing may also reduce carbon emissions into the atmosphere by charging both a monetary price and a carbon price for a product or service wherein the carbon price for each purchasable item (good or service) may correspond to a number of Kg of Co2 emitted by the manufacture/sale/use of the purchasable item.
    Type: Application
    Filed: July 20, 2022
    Publication date: November 3, 2022
    Applicant: Climate Karma Solutions Inc.
    Inventors: Mark KLEIN, Wendell BROWN
  • Publication number: 20220348192
    Abstract: This disclosure relates to systems and techniques for identifying collisions, such as relatively low energy impact collisions involving an autonomous vehicle. Sensor data from a first sensor modality in a first array may be used to determine a first estimated location of impact and second sensor data from a second sensor modality in a second array may be used to determine a second estimated location of impact. A low energy impact event may be configured when the first estimated location of impact corresponds to the second estimated location of impact.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 3, 2022
    Inventors: Marina Camille Josephs, Mark Alan Bates, Nam Gook Cho, Subhasis Das, Markus Jost, Amanda Brown Prescott, Valerie Bumbaca Randolph, Subasingha Shaminda Subasingha
  • Patent number: 11485648
    Abstract: The present invention provides a method of managing operation of a point-of-use fluid treatment arrangement for providing treated fluid to at least one end user. The point-of-use fluid treatment arrangement comprises a fluid supply source provided by an operator, at least one fluid outlet for providing fluid to an end user, in which the at least one fluid outlet is in fluid communication with and spaced downstream from a point of supply of the fluid supply source, at least one point-of-use or point-of-entry fluid treatment device located at or adjacent a corresponding fluid outlet, and at least one communication unit.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: November 1, 2022
    Assignee: Datumpin, Inc.
    Inventors: Philip Colin Chandler, Darren Mark Brown, Michael Sean Finney
  • Patent number: 11478755
    Abstract: A fluid processing system includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes a spinning membrane separator, first and second syringes, and a flow control cassette. The reusable hardware includes a spinning membrane separator drive coupled to the spinning membrane separator, first and second syringe pumps coupled to the first and second syringes respectively, a control cassette interface coupled to the flow control cassette, and at least one controller coupled to the spinning membrane separator drive, the first and second syringe pumps, and the control cassette interface. The controller is configured to selectively operate the drive, the first and second syringe pumps, and the interface to provide a procedure according to a protocol.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: October 25, 2022
    Assignee: Fenwal, Inc.
    Inventors: Christopher J. Wegener, Bret M. Olson, Carolyn Kos, Timothy Getschman, Mark J. Brierton, Robert A. Brown
  • Patent number: 11479747
    Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: October 25, 2022
    Assignee: CLAREMONT BIOSOLUTIONS LLC
    Inventors: Robert W. Doebler, Mark Brown, Tanya Ferguson, Bruce Irvine, James D. Sterling
  • Patent number: 11480030
    Abstract: A thermal expansion system for actuating a remote operated sleeve assembly to open and close ports in a housing for fluidly communicating between a bore of a tubular string in a wellbore to the formation utilizes actuation of a propellant charge to create expanding gas and heat in a combustion chamber to directly act on one side of a piston connected to an axially moveable sleeve supported in the housing to shift the sleeve in one direction. Ignition of another propellant charge in a combustion chamber on an opposing side of the piston is used to directly shift the sleeve in an opposing direction.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: October 25, 2022
    Inventors: Per Angman, Mark Andreychuk, Allan Petrella, Matthew Brown
  • Publication number: 20220333104
    Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated ocular diseases.
    Type: Application
    Filed: March 26, 2021
    Publication date: October 20, 2022
    Inventors: Jayaprakash K. Nair, Martin A. Maier, Vasant R. Jadhav, Mark Keating, Kevin Fitzgerald, Stuart Milstein, Kirk Brown, Muthiah Manoharan
  • Publication number: 20220337639
    Abstract: Examples can include a system for video chat cycles within a social media application. An organizer platform can be used to design a schedule for the video chat cycles. This can include scheduled organizer content before, after, and between video chats. The organizer content can include graphics, video, and even live streams by the organizer.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 20, 2022
    Inventors: Jeff Emile, Mark Brown