Abstract: Disclosed are media, supplements and methods for expanding mammalian lymphocytes or progenitors thereof, such as B cells, T cells, or NK cells. The disclosed media, supplements and methods may be used to expand mammalian lymphocytes or progenitors thereof plated as single cells, or at a clonal cell density. In some embodiments, the disclosed media, supplements and methods may also differentiate/activate the lymphocytes during expansion. The media, supplements and methods of this disclosure may be used in serum-free and feeder-free culture workflows.

Abstract: A system includes a transmitting horn coupled to a first robotic arm and positionable in immediate non-contacting proximity to a transparency, and configured to emit an emitted signal comprising a focused energy beam for impingement on the transparency. The system further includes a receiving horn coupled to a second robotic arm and positionable relative to the transmitting horn in immediate proximity to the transparency, and configured to receive a received signal comprising at least a portion of the emitted signal after transmission through or reflection off of the transparency. The system also includes a processor configured to move the first robotic arm and the second robotic arm in a coordinated manner along a preprogrammed measurement path, and determine at least one transparency characteristic based on an analysis of the received signal.

Abstract: A system recommends to a healthcare professional (HCP) (230) medical literature that is of relevance to the HCP's patients. The system communicates with the HCP (230) and accesses electronic health record (EHR) documents in a database (210) associated with the HCP's patients. The system analyzes the contents of the EHR documents to query a medical-literature database (212) for publications that are deemed relevant to the EHR documents. The extracted publications are then presented to the HCP.

Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.

Abstract: The present application provides an aft plate removal tool for servicing a combustor. The combustor includes an aft plate with a central passage and a number of tubes extending through the aft plate. The aft plate removal tool includes a central screw, a lower housing attached to the central screw, the lower housing including a number of spring loaded lower housing feet, and an upper housing attached to the center screw, the upper housing including a number of spring loaded upper housing feet. The aft plate removal tool is inserted through the central passage of the aft plate such that rotation of the upper housing advances the spring loaded upper housing feet against the aft plate until the spring loaded upper housing feet push the aft plate off of the tubes.

Abstract: Systems, kits, and methods for contactless application of mixed concentrates and diluents are disclosed herein. According to an aspect, a system comprising a mix and storage container defining an interior and a first opening and a second opening. The first opening, the second opening and the interior are fluidly connected. Further, the system includes a connector that defines a first end, a second end, and a passageway that extends between the first end and the second end. The first end of the connector is attached to the first opening of the mix and storage container. The connector further defines an opener configured to engage and open a sealed portion of the concentrate container for release of a concentrate from within the concentrate container through the passageway and into the interior of the mix and storage container for mixing with a diluent. The system also includes an application tool.

Abstract: This invention, in embodiments, relates to a roofing system that includes a roof deck, a plurality of tapered insulation panels applied onto the roof deck, at least one non-tapered insulation panel applied onto the plurality of tapered insulation panels, and a membrane layer applied onto the at least one non-tapered insulation panel. This invention, in embodiments, further relates to a roof assembly kit that includes a plurality of tapered insulation panels and instructions for installation, as well as a method of installing such a roofing system.

Abstract: A power tool includes a housing with a motor housing portion, a handle portion extending from the motor housing portion, and a battery receptacle configured to receive a battery pack. An electric motor is supported in the motor housing portion. A trigger extends from the handle portion. An actuator is located on a top surface of the housing opposite the battery receptacle and includes a magnet. A sensor is positioned adjacent the actuator to detect a position of the magnet and output an actuator signal representative of a position of the actuator based on the detected position of the magnet. A controller is configured to control the electric motor based on the actuator signal received from the sensor such that the electric motor rotates in a first direction when the actuator is in the first position and rotates in an opposite direction when the actuator is in the second position.

Abstract: A method for fill level determination, which can include receiving a set training set, training a neural network, selecting reference images, and/or determining a container fill level. A system for fill level determination, which can include a computing system, one or more containers, and/or one or more content sensors.

Abstract: A smartphone and app executed on the smartphone are used for personal pathogen status verifying that allows an entity to control access to an area of congregation (AOC) at one or more points of entry (POE). In one embodiment, the system may be used for the SARS-CoV-2 virus, but may be similarly used for other pathogens.

Abstract: A label modification unit may receive a label modification input that indicates a label modification associated with content being written to a label or erased from the label. The label modification unit may identify an area of the label that is associated with the label modification according to the label modification input. The label modification unit may determine, based on a size of the area, a spot size of a light beam that is configured to be emitted by a laser printhead to modify the content within the area. The label modification unit may determine, based on the spot size and the content, an optical path configuration for the laser printhead. The label modification unit may operate the laser printhead according to the optical path configuration to write the content to the area or erase the content from the area.

Abstract: Techniques are disclosed for providing method for providing an event timer for event synchronization across Kubernetes clusters. The event timer is configured to provide event synchronization on behalf of microservice instances in the cloud computing environment. In response to a request for an event timer for a timed event, it is determined whether the requested event timer has been started for a second microservice instance. If the requested event timer has been started, a state of the requested event timer is sent to the first microservice instance If the requested event timer has not been started, the requested event timer is instantiated, and a state of the instantiated event timer is stored in a database. The instantiated event timer is independent of the first and second microservice instances. In response to an expiration of the event timer, a single callback for processing of the event is generated.

Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.

Abstract: A method of generating a display object is provided, the method comprising operating a first processor comprised within a first device to: execute an application; generate an display object associated with the application; output the active display object on the first device; transmit the display object to a second device for output by the second device; and receive user input to the application via the display object output on the second device.

Abstract: A system includes a robotic arm of a robotic device, an imaging device coupled to the robotic arm, and a processor configured to control movement of the robotic arm to move the imaging device along a preprogrammed measurement path of a transparency while prompting the imaging device to record images of localized portions of the transparency. The processor is configured to determine one or more localized transparency characteristics based on an analysis of the images of the localized portions.

Abstract: The present disclosure provides methods for the acute treatment of migraine with or without aura, comprising the administration of ubrogepant. In particular, the present disclosure provides methods for the acute treatment of migraine in patients having hepatic impairment; in patients with renal impairment; and in patients concurrently taking CYP3A4 modulators or BCRP and/or P-gp only inhibitors.

Abstract: The invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Serpina1 gene, and methods of using such RNAi agents to inhibit expression of Serpina1 and methods of treating subjects having a Serpina1 associated disease, such as a liver disorder.

Abstract: A profile or article formed from a moisture- and/or thermo-curable elastomeric polymer composition including: (A) at least one ethylene-olefinic monomer-silane polymer; wherein the polymer has an olefinic monomer content of from 5 weight percent to 50 weight percent and a silane content of from 0.1 weight percent to 2.5 weight percent; and wherein the polymer has a melt index of from 0.1 gram/10 minutes to 10.0 grams/10; and (B) at least one silanol condensation catalyst; a shaped article made from the above elastomeric polymer composition; and a method of making a shaped article using the above elastomeric polymer composition.

Abstract: Connectors and methods for contactless transfer of fluid between containers are disclosed. According to an aspect, a connector includes a body that defines a first end, a second end, and a passageway that extends between the first end and the second end, wherein the first end and second end are configured to attach to a first container and a second container, respectively. The passageway provides a pathway between the first and second containers when the first and second containers are attached to the first and second ends, respectively. Further, the connector includes an opener configured to engage and open the first container for release of a fluid from within the first container through the passageway and into the second container when the first and second containers are attached to the first and second ends, respectively.