Abstract: Provided herein are compositions, systems, and methods for causing weight loss and treating and/or preventing a disease or condition, such as obesity, diabetes, and cancer, with an agent or procedure that inhibits the TMA/FMO3/TMAO pathway in a subject.

Abstract: Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).

Abstract: A method includes receiving, by a real-time Data Warehouse (rDW) from a first task, a first dataset and spreading the first dataset to produce a first plurality of objects, where the first plurality of objects includes a first object and a second object. The method also includes storing the first object in a first location in an rDW data repository and storing the second object in a second location in the rDW data repository.

Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.

Abstract: An ambient or atmospheric pressure ion source is disclosed that comprises a laser source (1) that generates ions and/or neutral particles from a target (2). A transfer device (10) causes the ions and/or neutral particles to pass along a first path or axis within the transfer device (10), while a secondary activation device (6) directs laser radiation or photons along, across or over at least a portion of the first path or axis to cause secondary activation of the ions and/or neutral particles.

Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25. In particular, the present disclosure provides sequences of anti-human CD25 antibodies, which do not block the binding of CD25 to IL-2 or IL-2 signalling. Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical composition and methods of treatment, in particular for treating cancer.

Abstract: The disclosed technology relates to log file processing techniques for providing thermostat configuration guidance. A system may be configured to receive, from a load forecast engine, a plurality of load forecasts associated with a thermostat set point schedule and receive, from a user device, a change in the thermostat set point schedule. The system generates a hybrid load forecast by selecting a portion of a first load forecast in the plurality of load forecasts and a portion of a second load forecast in the plurality of the load forecasts based on the change in the change in the thermostat set point schedule. The system calculates a cost for the change in the thermostat set point schedule based on the hybrid load forecast and a fee schedule and provides the user device with the cost for the change in the thermostat set point schedule.

Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25. In particular, the present disclosure provides sequences of anti-human CD25 antibodies, which do not block the binding of CD25 to IL-2 or IL-2 signalling. Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical composition and methods of treatment, in particular for treating cancer.

Abstract: A method of mass or ion mobility spectrometry is disclosed that uses the Leidenfrost effect to cause a liquid to be repelled away from a heated surface so as to levitate above there-above. The repelled liquid is urged so as to move along the surface in a predetermined direction, for example, by the geometric configuration of the heated surface.

Abstract: A medical device inspection scope may include a cylindrical outer layer having a diameter of less than 2 millimeters or even less than 1 millimeter, a cylindrical inner layer disposed concentrically within the outer layer, a circumferential space between the outer layer and the inner layer, and an inner lumen formed by the inner layer. The scope also includes multiple light transmitting fibers disposed in the circumferential space and a camera module disposed in the inner lumen. The light fibers may be designed to transmit illumination light and ultraviolet light. The scope may also optionally include a stiffening member.

Abstract: The present disclosure provides antibody sequences found in antibodies that bind to human CD25. In particular, the present disclosure provides sequences of anti-human CD25 antibodies, which do not block the binding of CD25 to IL-2 or IL-2 signalling. Antibodies and antigen-binding portions thereof including such sequences can be used in pharmaceutical composition and methods of treatment, in particular for treating cancer.

Abstract: Methods and apparatuses for transmitting ions through an aperture are described. In one embodiment, a mass spectrometer may include an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focused to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.

Abstract: Disclosed herein is an ion analysis instrument comprising a Time of Flight (“TOF”) mass analyser comprising a reflectron. The instrument is operable in at least a first mode and a second mode, wherein in said first mode ions are caused to turn around at a first point in the reflectron and wherein in said second mode ions are caused to turn around at a second point in the reflectron such that the distance traveled by ions within the Time of Flight mass analyser is greater in the second mode than the distance traveled by ions within the Time of Flight mass analyser in the first mode. In this way, the operating modes can be selectively optimised for the analysis of ions of different masses.

Abstract: Syntactic polyurethane elastomers are made using a non-mercury catalyst. The elastomer is made from a reaction mixture containing a polymer polyol which has a liquid polyether polyol as a continuous phase and polymer particles dispersed in the liquid polyether polyol, a chain extender, a polyisocyanate and microspheres. The elastomer adheres well to itself, which makes it very useful as thermal insulation for pipelines and other structures that have a complex geometry.

Abstract: A method of mass or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric and a sub-atmospheric pressure region of the spectrometer, wherein the latter comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionizing the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap. The proximity of the sample to the ion guide or trap allows analyte ions from the sample to be captured efficiently.

Abstract: Syntactic polyurethane elastomers are made using a non-mercury catalyst. The elastomer is made from a reaction mixture containing a polyether polyol having a low amount of terminal unsaturation, a chain extender, a polyisocyanate and microspheres. The elastomer adheres well to itself, which makes it very useful as thermal insulation for pipelines and other structures that have a complex geometry.

Abstract: A steering actuator comprising a shaft having an input coaxial with an output, wherein the output is in drivable communication with one or more wheels of a vehicle, and a locking mechanism configured to enable the shaft to rotate in both a first direction and a second direction in response to torque provided at the input, and prevent the shaft from rotating in both the first direction and the second direction in response to torque provided at the output.

Abstract: A method of mass spectrometry is disclosed that includes transforming mass spectral data to produce frequency-domain mass spectral data, modifying the frequency-domain mass spectral data to produce modified frequency-domain mass spectral data by attenuating and/or removing one or more ranges of the frequency-domain mass spectral data that relate to noise associated with peaks of interest in the mass spectral data, and transforming the modified frequency-domain mass spectral data to produce modified mass spectral data.

Abstract: The embodiments herein provide a roll-on applicator designed to waterproof leather products such as boots, gloves, and more. The applicator discharges a non-liquid wax material through a dispenser and directly applies the non-liquid wax material to a leather product for protection. The applicator avoids penetration of rainwater, mud and other wet debris into the leather products and leaking onto clothing garments or skin of the user. The applicator is very compact and portable thereby enabling a packing of the applicator conveniently into a backpack, hiking pack, in a pocket, and more, due to small size. The applicator saves extensive time and frustration of the user when compared to dealing with bulky and difficult-to-use waterproof applicators.

Abstract: A novel assay and a suite of devices may isolate nucleic acids from prokaryotic and eukaryotic cells and prepare samples for real-time (quantitative) polymerase chain reaction (PCR) analysis. The assay may employ an aqueous-based non-alcohol approach that yields robust RNA quality. The suite of ready-to-use devices may provide pre-loaded reagents in liquid and lyophilized formats to enable rapid manual operation in a laboratory or remote field environments. The assay and devices may be particularly suitable to analysis in microgravity or deep space environments.