Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: The present disclosure relates to a method and a system of determining transition characteristics during a transition in a relative concentrations of the at least two components of a gas stream. The transition characteristics, including one or more of a relative concentration transition crosspoint, a relative concentration transition leading edge, and a relative concentration transition trailing edge, may be determined based on one or more of a) a change in the one or more of a pressure and a flow rate of the gas stream, and b) a rate of change of the one or more of the pressure and the flow rate.

Abstract: The present disclosure relates to separation methods, apparatuses, and systems for obtaining a gas product from a gas mixture. A component of a gas mixture may be nonuniformly adsorbing on a quantity of adsorbent and a portion of the quantity of adsorbent isolated and exposed to a partial vacuum to obtain the gas product.

Abstract: Combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, compositions thereof, and methods of using them are provided.

Abstract: A method for generating a knitted article having a first, second and third opening, the knitted article adapted to cover at least a groin, a first thigh portion and a second thigh portion of a human body. The method includes using flatbed knitting machine to knit a first portion of the knitted article for covering the first thigh portion, then to knit a second portion of the knitted article for covering the groin and then to knit a third portion of the knitted article for covering the second thigh portion. The first, second and third portions of the knitted article form a one-piece, non-planar knitted article. A pair of edges of the knitted article are affixed to form a first seam, and another pair of edges are affixed to form a second seam facing away from the first seam.

Abstract: Combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, compositions thereof, and methods of using them are provided.

Abstract: The present disclosure relates to separation methods, apparatuses, and systems for obtaining a gas product from a gas mixture. A component of a gas mixture may be nonuniformly adsorbing on a quantity of adsorbent and a portion of the quantity of adsorbent isolated and exposed to a partial vacuum to obtain the gas product.

Abstract: An article of apparel providing dynamic support for an appendage of a person is discussed herein. The article of apparel can include a support garment control device configured to provide dynamic support. The support garment control device can include a control lace coupled to a support portion of the article of apparel. In an example, the support garment control device configured to apply a first tension on the control lace, lock the support garment control device at the first tension to inhibit movement of the control lace in response to detecting a change in movement of the person, and unlock the support garment control device after a pre-determined event subsequent to the change in movement of the person.

Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: An adaptive support garment integrating directional fabrics to assist in providing adaptive support to select portions of the garment is discussed herein. The adaptive support garment can include a first directional fabric, a second directional fabric, and a tension device. The first directional fabric includes first directional fibers, and the first directional fabric can be coupled to a fixed portion of the adaptive support garment. The second directional fabric includes second directional fibers, and the second directional fabric can be coupled to a movable control structure portion of the adaptive support garment. The tension device can be coupled to the movable control structure and configured to apply a tension in a first direction on the movable control structure. In operation, the first directional fibers can engage with the second directional fibers to resist movement in a second direction opposite the first direction.

Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: A control system for use within an adaptive support garment is discussed herein. The control system can include a lace spool, a ratchet mechanism, an actuator, and a control circuit. The lace spool can include a lace groove adapted to accumulate a portion of a lace cable coupled to a support structure within the adaptive support garment. The ratchet mechanism can be configured to control rotation of the lace spool during operation of the control system. The actuator can be adapted to control engagement of the ratchet mechanism. The control circuit electrically can be coupled to the actuator and can be configured to operate the actuator to engage or disengage the ratchet mechanism. In operation, rotation of the lace spool controls an effective length of the lace cable to provide adaptive support.

Abstract: An article of apparel providing dynamic support for an appendage of a person is discussed herein. The article of apparel can include a support garment control device configured to provide dynamic support. The support garment control device can include a control lace coupled to a support portion of the article of apparel. In an example, the support garment control device configured to apply a first tension on the control lace, lock the support garment control device at the first tension to inhibit movement of the control lace in response to detecting a change in movement of the person, and unlock the support garment control device after a pre-determined event subsequent to the change in movement of the person.

Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: Combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, compositions thereof, and methods of using them are provided.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.