Abstract: Systems and methods for detecting anomalies in aviation data communication systems (e.g., air traffic control surveillance systems), include a processor receiving device status information. A variational autoencoder receives and optimizes the device status information and determines whether it qualifies as an anomaly. Optimized device status information is compared to either non-anomalous or anomalous device status data in a latent space of the variational autoencoder. The latent space preferably includes an n-D point scatter plot and hidden vector values. The processor optimizes the device status information by generating a plurality of probabilistic models of the device status information and determining which of the plurality of models is optimal. A game theoretic optimization is applied to the plurality of models, and the best model is used to generate the n-D point scatter plot in latent space. An image gradient sobel edge detector preprocesses the device status information prior to optimization.

Abstract: This disclosure describes an additive manufacturing method that includes monitoring a temperature of a portion of a build plane during an additive manufacturing operation using a temperature sensor as a heat source passes through the portion of the build plane; detecting a peak temperature associated with one or more passes of the heat source through the portion of the build plane; determining a threshold temperature by reducing the peak temperature by a predetermined amount; identifying a time interval during which the monitored temperature exceeds the threshold temperature; identifying, using the time interval, a change in manufacturing conditions likely to result in a manufacturing defect; and changing a process parameter of the heat source in response to the change in manufacturing conditions.

Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: A control system for use within an adaptive support garment is discussed herein. The control system can include a lace spool, a ratchet mechanism, an actuator, and a control circuit. The lace spool can include a lace groove adapted to accumulate a portion of a lace cable coupled to a support structure within the adaptive support garment. The ratchet mechanism can be configured to control rotation of the lace spool during operation of the control system. The actuator can be adapted to control engagement of the ratchet mechanism. The control circuit electrically can be coupled to the actuator and can be configured to operate the actuator to engage or disengage the ratchet mechanism. In operation, rotation of the lace spool controls an effective length of the lace cable to provide adaptive support.

Abstract: An article of apparel providing dynamic support for an appendage of a person is discussed herein. The article of apparel can include a support garment control device configured to provide dynamic support. The support garment control device can include a control lace coupled to a support portion of the article of apparel. In an example, the support garment control device configured to apply a first tension on the control lace, lock the support garment control device at the first tension to inhibit movement of the control lace in response to detecting a change in movement of the person, and unlock the support garment control device after a pre-determined event subsequent to the change in movement of the person.

Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: Combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, compositions thereof, and methods of using them are provided.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

Abstract: A respiration-assistance apparatus or method can include or use a lifting element such as to cyclically push, pull, or lift, toward a superior direction of the subject, at least one subject region during an inhalation portion of a respiration cycle of the subject. A cyclical member can couple the lifting element to a fixed reference. Abdominal or ribcage compression can be provided. A multi-action or other cam can be used, such as together with a reciprocating element. Examples can be configured for use with a wheelchair, a bed, a vacuum or suction affixation element, a wearable garment, etc.

Abstract: Techniques and architectures for data ingestion in an environment having a distributed data storage system. A request to import data into the environment. The data to be imported from an external source through an application programming interface (API). The request is analyzed to determine if the request corresponds to a request to import a large data load. The data is staged if the request is for the large data load. Data management jobs are created to cause the data to be stored in one or more nodes of the distributed data storage system. The data management jobs are transmitted to corresponding nodes in the distributed data storage system. The jobs are executed asynchronously to cause the data to be stored in the nodes.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: A respiration-assistance apparatus or method can include or use a lifting element such as to cyclically push, pull, or lift, toward a superior direction of the subject, at least one subject region during an inhalation portion of a respiration cycle of the subject. A cyclical member can couple the lifting element to a fixed reference. Abdominal or ribcage compression can be provided. A multi-action or other cam can be used, such as together with a reciprocating element. Examples can be configured for use with a wheelchair, a bed, a vacuum or suction affixation element, a wearable garment, etc.

Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: An adaptive support garment integrating directional fabrics to assist in providing adaptive support to select portions of the garment is discussed herein. The adaptive support garment can include a first directional fabric, a second direction fabric, and a tension device. The first directional fabric includes first directional fibers, and the first directional fabric can be coupled to a fixed portion of the adaptive support garment. The second directional fabric includes second directional fibers, and the second directional fabric can be coupled to a movable control structure portion of the adaptive support garment. The tension device can be coupled to the movable control structure and configured to apply a tension in a first direction on the movable control structure. In operation, the first directional fibers can engage with the second directional fibers to resist movement in a second direction opposite the first direction.

Abstract: A control system for controlling tension applied to a lace cable coupled to a support structure of an adaptive support garment is discussed herein. The control system can include a lace spool, a damper mechanism, and a locking ring. The lace spool can include a lace groove to receive the lace cable and a rotary bias member to apply rotational tension to resist extension of the lace cable out of a housing holding the control system. The damper mechanism is engagable with the lace spool to generate an additional rotational tension resisting extension of the lace cable out of the housing. The locking ring is frictionally coupled to the lace spool, and the locking ring can include a lock wedge adapted to disengage the damper mechanism upon rotation into a pre-determined rotational position relative to the damper mechanism.

Abstract: An article of apparel providing dynamic support for an appendage of a person is discussed herein. The article of apparel can include a support garment control device configured to provide dynamic support. The support garment control device can include a control lace coupled to a support portion of the article of apparel. In an example, the support garment control device configured to apply a first tension on the control lace, lock the support garment control device at the first tension to inhibit movement of the control lace in response to detecting a change in movement of the person, and unlock the support garment control device after a pre-determined event subsequent to the change in movement of the person.

Abstract: A control system for use within an adaptive support garment is discussed herein. The control system can include a lace spool, a ratchet mechanism, an actuator, and a control circuit. The lace spool can include a lace groove adapted to accumulate a portion of a lace cable coupled to a support structure within the adaptive support garment. The ratchet mechanism can be configured to control rotation of the lace spool during operation of the control system. The actuator can be adapted to control engagement of the ratchet mechanism. The control circuit electrically can be coupled to the actuator and can be configured to operate the actuator to engage or disengage the ratchet mechanism. In operation, rotation of the lace spool controls an effective length of the lace cable to provide adaptive support.

Abstract: The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.