Abstract: The invention relates to new methods of controlling the movement of polynucleotides through transmembrane pores. The invention also relates to new methods of characterising target polynucleotides using helicases.

Abstract: A ride control system includes a plurality of ride vehicles positioned within a course and configured to travel within the course. Each of the plurality of ride vehicles includes a vehicle controller configured to control movement of a respective one of the plurality of ride vehicles. Each of the plurality of ride vehicles also includes a position tracking system configured to facilitate identification of a location of the respective one of the plurality of ride vehicles within the course. Each of the plurality of ride vehicles further includes a vehicle transceiver in communication with the vehicle controller. The ride control system also includes a primary controller and a primary transceiver in communication with the primary controller. The ride control system further includes a primary wireless network formed by the vehicle transceiver and the primary transceiver to include at least the primary controller and the vehicle controller of each of the plurality of ride vehicles.

Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: Combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, and methods of using them are provided.

Abstract: A ride control system includes a plurality of ride vehicles positioned within a course and configured to travel within the course. Each of the plurality of ride vehicles includes a vehicle controller configured to control movement of a respective one of the plurality of ride vehicles. Each of the plurality of ride vehicles also includes a position tracking system configured to facilitate identification of a location of the respective one of the plurality of ride vehicles within the course. Each of the plurality of ride vehicles further includes a vehicle transceiver in communication with the vehicle controller. The ride control system also includes a primary controller and a primary transceiver in communication with the primary controller. The ride control system further includes a primary wireless network formed by the vehicle transceiver and the primary transceiver to include at least the primary controller and the vehicle controller of each of the plurality of ride vehicles.

Abstract: The invention relates to methods using constructs comprising a helicase and an additional polynucleotide binding moiety. The helicase is attached to the polynucleotide binding moiety and the construct has the ability to control the movement of a polynucleotide. The constructs can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: Techniques and systems for completing a database query. A time to complete a synchronous query in response to receiving an original database query is estimated by a database management system provided by one or more computing devices. A synchronous database query corresponding to the original database query is performed with the database management system if the estimated time to complete the synchronous query is less than a pre-selected threshold time. One or more asynchronous queries corresponding to the original database query are performed with the database management system if the estimated time to complete the synchronous query is greater than the pre-selected threshold time. A result, whether from a synchronous query or one or more asynchronous queries, is stored in an object within a non-relational database system.

Abstract: Managing data in a multitenant environment having a relational database and a non-relational database. A set of one or more policies for data retention corresponding to data stored in the relational database environment is received. The policies for data retention are defined on a tenant-by-tenant basis within the multitenant environment. The policies are deployed to data in the relational database on a tenant-by-tenant basis within the multitenant environment. Data to be copied from the relational database to the non-relational database is identified. The data to be copied in the non-relational database is stored while maintaining tenant isolation so that data belonging to the respective tenants is not accessible by other tenants when stored in the non-relational database.

Abstract: Systems and techniques for managing data in a relational database environment and a non-relational database environment. Data in the relational database environment that is static and to be maintained beyond a preselected threshold length of time is identified. The data is copied from the relational database and stored in the data the non-relational database. Access to the data is provided from the non-relational database via a user interface that accesses both the relational database and the non-relational database.

Abstract: Techniques and structures for providing a multitenant environment having both a relational database and a non-relational database. A database query is received with at least one server computing device providing a multitenant environment having a relational database system and a non-relational database system, the database query in a format corresponding to the relational database system. The query is parsed with the at least one server computing device to find one or more components of the query directed to data stored in the non-relational database system. One or more components of the query directed to data stored in the non-relational database system are converted to one or more scans of the non-relational database system. Results from the query of the relational database system and results from the one or more scans of the non-relational database system are collected. The results from the query and the results of the one or more scans to a combined result are combined.

Abstract: Techniques and mechanisms to manage data. A relational database environment having at least a relational database storage device is coupled with a server entity. Data stored in the relational database is stored in a custom object, which is one or more custom database tables that allow a customer/tenant/organization to store information unique to the customer/tenant/organization. A non-relational database environment having at least a non-relational database storage device is also coupled with the server entity. Data stored in the non-relational database is immutable. A single user interface and search language is utilized by the server entity to provide access to both the relational database environment and the non-relational database environment.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

Abstract: A respiration-assistance apparatus or method can include or use a lifting element such as to cyclically push, pull, or lift, toward a superior direction of the subject, at least one subject region during an inhalation portion of a respiration cycle of the subject. A cyclical member can couple the lifting element to a fixed reference. Abdominal or ribcage compression can be provided. A multi-action or other cam can be used, such as together with a reciprocating element. Examples can be configured for use with a wheelchair, a bed, a vacuum or suction affixation element, a wearable garment, etc.

Abstract: Novel combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, and methods of using them are provided.

Abstract: Novel pharmaceutical formulations of a beta-2 agonist for inhaled administration via the nose or mouth, and methods of using them are provided.

Abstract: A process for preparing a powder coated reconstituted cellulosic substrate comprising providing a reconstituted cellulosic substrate comprising cellulose based particles and a cured formaldehyde based resin, wherein an inorganic salt is dispersed throughout the substrate; applying a powder coating composition to at least one surface of said substrate; and curing the powder coating composition.

Abstract: The present invention provides fibers, foams, films and nonwoven fabrics having more than one skin treatment benefit and/or improved skin treatment benefit(s) and to products incorporated such fibers, foams, films and fabrics. The present invention also provides a method of forming fibers, nonwoven fabrics, porous films and foams with multiple skin treatment additives that impart a number of skin health attributes.

Abstract: A film cover for use in absorbent materials such as feminine care products, surgical drapes, fenestration reinforcement, absorbent pads and the like including a polymeric film having a top planar surface and a bottom planar surface and forming a plurality of apertures, at least a portion of which have an aperture region having a higher wettability than a portion of the top planar surface of the polymeric film.

Abstract: Embossed textured films are made by feeding a thin thermoplastic polymer barrier film through the nip of a bonding roll assembly having a patterned roll and an anvil roll rotating at different circumferential speeds which differ by 5% to 200%. The bond pattern is imparted to the film as well as additional texture due to the differential speeds of the rollers thereby creating an embossed, textured barrier film having improved hand and a hydrohead in excess of about 30 mbar.