Patents by Inventor Mark Cronin

Mark Cronin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240158398
    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: April 20, 2023
    Publication date: May 16, 2024
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian Lewis Hodous, Joseph L. Kim, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin
  • Patent number: 11634422
    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: April 25, 2023
    Assignee: Blueprint Medicines Corporation
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian Lewis Hodous, Joseph L. Kim, Brett D. Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin
  • Publication number: 20220315585
    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: May 29, 2020
    Publication date: October 6, 2022
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Paul E. Fleming, Brian L. Hodous, Joseph L. Kim, Josh Waetzig, Brett Williams, Douglas Wilson, Kevin J. Wilson, Mark Cronin
  • Publication number: 20200051685
    Abstract: A system configured to: (a) receive, from a computing device, service request data including a service to be performed on behalf of a member of a carrier organization; (b) receive bid data from one or more supplier devices based on the service; (c) provide the bid data to an agent device; (d) receive winning bid data from the agent device based on the bid data; (e) transmit an electronic notification to a winning supplier device associated with a winning supplier according to the winning bid data; (f) receive a first confirmation from the winning supplier device that the service is completed; (g) receive a second confirmation from a member device of the member that the service is completed; and (h) authorize payment to a financial account associated with the winning supplier based on first confirmation and second confirmation.
    Type: Application
    Filed: August 8, 2018
    Publication date: February 13, 2020
    Inventors: Henry S. Thompson, Dharmendra R. Chokshi, Mark Cronin, Antony L. Kerz
  • Patent number: 10280204
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: May 7, 2019
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 10233186
    Abstract: Described herein are compounds, such as compounds of formula (I) and pharmaceutically acceptable salts thereof, that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: March 19, 2019
    Assignee: BLUEPRINT MEDICINES CORPORATION
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Mark Cronin, Paul E. Fleming, Brian L. Hodous, Joseph L. Kim, Brett Williams, Douglas Wilson, Kevin J. Wilson
  • Patent number: 10040834
    Abstract: A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: August 7, 2018
    Assignee: TUFTS UNIVERSITY
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 9969134
    Abstract: A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: May 15, 2018
    Assignee: Trustees of Tufts College
    Inventors: David Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 9802374
    Abstract: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 31, 2017
    Assignee: TUFTS UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
  • Publication number: 20170298069
    Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.
    Type: Application
    Filed: April 14, 2017
    Publication date: October 19, 2017
    Inventors: Natasja Brooijmans, Jason D. Brubaker, Mark Cronin, Paul E. Fleming, Brian L. Hodous, Joseph L. Kim, Josh Waetzig, Brett Williams, Douglas Wilson, Kevin J. Wilson
  • Publication number: 20160376331
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Application
    Filed: February 18, 2016
    Publication date: December 29, 2016
    Inventors: David L. KAPLAN, Fiorenzo OMENETTO, Brian LAWRENCE, Mark CRONIN-GOLOMB
  • Patent number: 9513405
    Abstract: A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: December 6, 2016
    Assignee: TUFTS UNIVERSITY
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Publication number: 20140349380
    Abstract: A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
    Type: Application
    Filed: January 13, 2014
    Publication date: November 27, 2014
    Applicant: TUFTS UNIVERSITY
    Inventors: Fiorenzo OMENETTO, David L. KAPLAN, Brian LAWRENCE, Mark CRONIN-GOLOMB
  • Publication number: 20140205797
    Abstract: A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.
    Type: Application
    Filed: October 28, 2013
    Publication date: July 24, 2014
    Applicant: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Publication number: 20140039159
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Application
    Filed: July 11, 2013
    Publication date: February 6, 2014
    Inventors: David L. KAPLAN, Fiorenzo OMENETTO, Brian LAWRENCE, Mark CRONIN-GOLOMB
  • Publication number: 20130323811
    Abstract: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 5, 2013
    Applicant: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
  • Patent number: 8574461
    Abstract: A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: November 5, 2013
    Assignee: Tufts University
    Inventors: David Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb
  • Patent number: 8529835
    Abstract: A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: September 10, 2013
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb, Irene Georgakoudi
  • Publication number: 20120270864
    Abstract: The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, to their use in the treatment of bacterial infections, and to their methods of preparation.
    Type: Application
    Filed: May 18, 2012
    Publication date: October 25, 2012
    Inventors: Andrew Aydon Godfrey, Janelle Comita-Prevoir, Mark Cronin, Bolin Geng, Folkert Reck
  • Patent number: 8195021
    Abstract: A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.
    Type: Grant
    Filed: November 5, 2007
    Date of Patent: June 5, 2012
    Assignee: Tufts University/Trustees of Tufts College
    Inventors: David L. Kaplan, Fiorenzo Omenetto, Brian Lawrence, Mark Cronin-Golomb