Patents by Inventor Mark D. Scott

Mark D. Scott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10561685
    Abstract: This disclosure relates to a cellular-based therapies for modulating the level of regulatory T cells (Treg) and/or the level of pro-inflammatory T cells (Th17/Th1). To provide these therapeutic effects, a combination comprising at least one a cellular pro-tolerogenic preparation and at least one a cellular pro-inflammatory preparation are administered sequentially.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: February 18, 2020
    Assignee: CANADIAN BLLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 10394415
    Abstract: A method, system or computer usable program product for providing secure user authentication including presenting a displayed representation of a three dimensional object having multiple selection areas, wherein respective selection areas are represented on at least two faces of the object and a symbol is depicted in each of the multiple selection areas; receiving a sequence of user inputs including a plurality of user selections of respective selection areas of the object indicating selection of the respective symbol and at least one user input indicating a movement of the object between the two faces so that user selection of selection areas on each of the two faces is accomplished; utilizing a processor to compare the sequence of user inputs to a predetermined authentication sequence stored in memory; and responsive to a positive comparison of the predetermined authentication sequence, providing user authentication.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: August 27, 2019
    Assignee: International Business Machines Corporation
    Inventors: Yuk L. Chan, Michael D. Essenmacher, David B. Lection, Eric L. Masselle, Mark Allen Scott
  • Patent number: 10336290
    Abstract: A vehicle includes a body portion, an opening defined by the body portion, and an extendable bumper that is positioned in the opening and is moveable with respect to the body portions between an extended position and a retracted position. The extendable bumper includes an inflatable structure that causes movement of the extendable bumper between the retracted position and the extended position in response to inflation and deflation of the inflatable structure.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: July 2, 2019
    Assignee: Apple Inc.
    Inventors: Juan A. Lazaro, Erik Mikael Fermer, Alice C. Watts, Tommaso P. Rivellini, Christian Schermaier, John Raff, Derek C. Scott, David E. Kingman, Bryce A. Woollard, Samuel G. Fowle, Mark B. Rober, Ibuki Kamei, Donald R. Monroe, Jesse T. Buehler, Paul D. Yeomans
  • Patent number: 10296162
    Abstract: A method for providing secure user authentication including presenting a displayed representation of a three dimensional object having multiple selection areas, wherein respective selection areas are represented on at least two faces of the object and a symbol is depicted in each of the multiple selection areas; receiving a sequence of user inputs including a plurality of user selections of respective selection areas of the object indicating selection of the respective symbol and at least one user input indicating a movement of the object between the two faces so that user selection of selection areas on each of the two faces is accomplished; utilizing a processor to compare the sequence of user inputs to a predetermined authentication sequence stored in memory; and responsive to a positive comparison of the predetermined authentication sequence, providing user authentication.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: May 21, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Yuk L. Chan, Michael D. Essenmacher, David B. Lection, Eric L. Masselle, Mark Allen Scott
  • Patent number: 10188681
    Abstract: This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population. The non-proliferative allogeneic leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition with the latter leukocyte population. Cellular-based preparations and processes for achieving cellular therapy are also provided.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: January 29, 2019
    Assignee: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 10039787
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Therapeutic uses intended for the treatment/prevention of auto-immune diseases of such compositions are also provided.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: August 7, 2018
    Assignee: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 10039788
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Therapeutic uses for preventing or limiting graft rejection and GVHD of such compositions are also provided.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: August 7, 2018
    Assignee: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 10039786
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Acellular pro-tolerogenic compositions, process for making such composition as well as therapeutic uses of such compositions are also provided.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: August 7, 2018
    Assignee: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20170173078
    Abstract: This disclosure relates to a cellular-based therapies for modulating the level of regulatory T cells (Treg) and/or the level of pro-inflammatory T cells (Th17/Th1). To provide these therapeutic effects, a combination comprising at least one a cellular pro-tolerogenic preparation and at least one a cellular pro-inflammatory preparation are administered sequentially.
    Type: Application
    Filed: July 10, 2015
    Publication date: June 22, 2017
    Applicant: CANANDIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 9498496
    Abstract: This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, two allogeneic leukocyte populations are contacted (in vivo, in vitro or ex vivo) and one of these leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition. Cellular-based preparations and processes for achieving cellular therapy are also provided.
    Type: Grant
    Filed: July 12, 2013
    Date of Patent: November 22, 2016
    Assignee: CANADIAN BLOOD CERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20160206655
    Abstract: This invention relates to acellular-based therapies for decreasing the level of regulatory T cells (Treg) and/or increasing the level of pro-inflammatory T cells (Th17) to favor immune stimulation. To provide these therapeutic effects, an allogeneic leukocyte population is contacted with another leukocyte population and the acellular components produced are isolated. The leukocyte populations are contacted so as to allow pro-inflammatory allo-recognition. Acellular-based preparations and processes for achieving therapy are also provided.
    Type: Application
    Filed: December 13, 2013
    Publication date: July 21, 2016
    Applicant: CANADIAN BLOOD SERVICES
    Inventors: Mark D. SCOTT, Duncheng WANG, Wendy M. TOYOFUKU
  • Publication number: 20150209387
    Abstract: This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population. The non-proliferative allogeneic leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition with the latter leukocyte population. Cellular-based preparations and processes for achieving cellular therapy are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 30, 2015
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20150202229
    Abstract: This invention relates to cellular-based therapies for decreasing the level of regulatory T cells (Treg) and/or increasing the level of pro-inflammatory T cells (Th17) to favor immune stimulation. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population capable of proliferating. The leukocyte populations are contacted so as to allow pro-inflammatory allo-recognition. Cellular-based preparations and processes for achieving cellular therapy are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 23, 2015
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20150196597
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Therapeutic uses for preventing or limiting graft rejection and GVHD of such compositions are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: July 16, 2015
    Applicant: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20150174168
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Acellular pro-tolerogenic compositions, process for making such composition as well as therapeutic uses of such compositions are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: June 25, 2015
    Applicant: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20150164948
    Abstract: This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of miRNAs and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer. Therapeutic uses intended for the treatment/prevention of auto-immune diseases of such compositions are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: June 18, 2015
    Applicant: CANADIAN BLOOD SERVICES
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Publication number: 20140017218
    Abstract: This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, two allogeneic leukocyte populations are contacted (in vivo, in vitro or ex vivo) and one of these leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition. Cellular-based preparations and processes for achieving cellular therapy are also provided.
    Type: Application
    Filed: July 12, 2013
    Publication date: January 16, 2014
    Inventors: Mark D. Scott, Duncheng Wang, Wendy M. Toyofuku
  • Patent number: 8454934
    Abstract: A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: June 4, 2013
    Assignee: Canadian Blood Services
    Inventors: Mark D. Scott, Jayachandran N. Kizhakkedathu
  • Patent number: 8067151
    Abstract: A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded directly to the platelet or includes the polymer and a linker molecule such that the linker molecule is covalently bonded to the platelet and the polymer is covalently attached to the linker molecule. The polymer of each polymerated chemical of each modified platelet is polyethylene glycol (PEG) or a PEG derivative. Forming each modified platelet does not include modifying the platelet membrane of each platelet with a glycan-modifying agent. The at least one modified platelet is stored in a temperature range below 0° C. After being stored, the at least one modified platelet may be introduced into a subject to treat a condition related to a reduced platelet function.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: November 29, 2011
    Assignee: Canadian Blood Services
    Inventors: Elisabeth Maurer, Mark D. Scott, Nobu Kitamura
  • Patent number: 8007784
    Abstract: The present invention is directed to a non-immunogenic cellular composition comprising: a cell having a cell surface and antigenic determinants on the cell surface; an optional linker molecule covalently attached to the cell surface; and a hydrophilic, biocompatible, non-immunogenicity providing compound or polymer (e.g., polyethylene glycol or a derivative thereof) covalently attached to the linker molecule or directly to the cell. In one embodiment, the linker molecule is covalently attached directly to the antigenic determinant on the cell surface. In an alternate embodiment, the linker molecule may be covalently attached to a non-antigenic site on the cell surface, but will camouflage the antigenic determinant on the cell surface.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: August 30, 2011
    Assignee: Albany Medical College
    Inventors: Mark D. Scott, John W. Eaton