Abstract: The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder or for inducing weight loss: wherein R1 is: H; a straight or branched alkyl; a straight or branched alkyl substituted with at least one moiety selected from the group comprising: halogen, hydroxy, alkoxy, NH2, mono- or disubstituted amino, thiol, and phosphine; aryl; aralkyl; hydroxy; alkoxy; aryloxy; arylalkoxy; NH2; mono- or disubstituted amino; or halogen; X is: CH or N; L is absent or present, and when present is: an optionally substituted straight or branched C1-C10 alkyl, optionally containing one or more rings, and/or optionally containing one or more double bonds; and Ar is: an optionally substituted 5-membered unsaturated heterocyclic ring.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: The invention provides a compound of Formula (I) or a tautomer, isomer, prodrug, metal complex, or pharmaceutically acceptable salt thereof for use in the treatment of a metabolic disorder, wherein R1 is: a straight or branched C1-C20 alkoxy, preferably C1-C10 alkoxy group, optionally containing one or more rings, and/or optionally containing one or more double bonds; an alkoxycarbonyloxyalkoxy group bearing a straight, branched or cyclic alkyl; an aryloxy group; or an arylalkoxy group; R2 and R3 which can be the same or different, are: hydrogen; a straight or branched C1-C20 alkylcarbonyl or cyclic C3-C7 alkylcarbonyl group optionally containing one or more double bonds; an arylcarbonyl or arylalkylcarbonyl group; a straight or branched C1-C10 alkoxycarbonyl or cyclic C3-C7 alkoxycarbonyl group optionally containing one or more double bonds; an arylalkoxy carbonyl group; an amino group; a hydroxy group; or a group of general Formula (II) wherein Y is nitrogen, oxygen or sulfur and A is hydrogen or an amino g

Abstract: The present invention relates to compounds of Formula I which form hydrogels upon mixing with water, and to fibers which form from the compounds. The hydrogels and fibers are antibacterial and not toxic towards mammalian cells. Such compounds, hydrogels, and fibers are useful, for example, in the treatment of surfaces such as in dermal or internal wounds as a barrier layer, or any article which may require disinfection.

Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

Abstract: The present application relates to compounds of Formula (I) and salts thereof. The compounds of Formula (I) have antibacterial and anti-biofilm activities. The present application also relates to compositions comprising the compounds of Formula (I) or salts thereof, methods of treating or preventing bacterial infections using the compounds of Formula (I) or salts thereof, and methods of inhibiting biofilm formation using the compounds of Formula (I) or salts thereof.

Abstract: A flexible pipe includes: an inner liner formed as a tube and having an outer surface and an inner surface defining an inner diameter; a reinforcement layer bonded to the inner liner and including at least a first ply of reinforcing tape helically wrapped in a first helical direction about the inner liner and a second ply of reinforcing tape helically wrapped about the first ply of reinforcing tape, the second ply of reinforcing tape helically wrapped in a second helical direction opposite to the first helical direction; and an outer jacket applied over and bonded to the reinforcement layer, the outer jacket including a thermoplastic. A reinforcing tape for use in the pipe or other applications includes: a plurality of reinforcing fibers and a matrix about the plurality of reinforcing fibers to hold the reinforcing fibers in the form of a tape, the matrix including thermoplastic and an additive to increase the impact resistance of the thermoplastic.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: The present application relates to compounds of Formula (I) and salts thereof. The compounds of Formula (I) have antibacterial and anti-biofilm activities. The present application also relates to compositions comprising the compounds of Formula (I) or salts thereof, methods of treating or preventing bacterial infections using the compounds of Formula (I) or salts thereof, and methods of inhibiting biofilm formation using the compounds of Formula (I) or salts thereof.