Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. The reader component may communicate with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.

Abstract: Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

Abstract: Described, in certain respects, are unique methods and systems for treating fistulae and other passageways and openings in the body. In some embodiments, treatment will be performed on fistulae that include a passage extending through a subcutaneous wall or wall-like structure. Illustratively, such a passage can extend through a subcutaneous tissue wall that includes, at a minimum, portions of an intestinal wall, and in this regard, such a wall can have a first side that is provided by the luminal side of the intestines and a second subcutaneous side that is provided, for example, by the abluminal side of the intestines and/or by other subcutaneous tissues adhered to this abluminal side. Some inventive products and methods involve sealing off the passage from both sides of the wall, for example, where a sealing element is placed on each side of the wall over an opening to the passage.

Abstract: Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

Abstract: A pipe coupling for forming a pipe connection includes: a wall formed as a tube and including an inner surface defining an inner diameter and an outer surface; an electrical conductor supported by the wall and extending about a circumference of the coupling; and a pair of contacts exposed on the outer surface and electrically in contact with the electrical conductor for connecting an electrical power source to the electrical conductor.

Abstract: A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. Further, a tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal for compressing the liner outlet and closing any annular assembly clearance at the primary seal for obviating opportunity for seal extrusion under pressure. An axial position in the boss, and dimensional integrity, of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be integral with the boss. Reverse extrusion of the primary seal due to trapped gas and rapid decompression of the cylinder can be defeated by providing a leak path.

Abstract: The present disclosure relates generally to antimicrobial peptides, methods for their use, and methods for preparing devices having surfaces which are modified to incorporate OH said peptides. In some embodiments, the antimicrobial peptides are antimicrobial OH cationic peptides modified to comprise a thiol functional group.

Abstract: A method of disinfecting a contact lens storage case having a lid, the method comprising the steps of occluding the cavity of the case with the lid; and actively drying the case by heating the case for about three hours at about 60 degrees Celsius.

Abstract: The embodiments described include graft devices for reinforcing patient tissue structures and methods of making and using the graft devices. In certain embodiments the graft devices have a remodelable extracellular matrix material graft body defining a slot and having a portion receivable through the slot to form a closed loop. Such graft devices can be used in encircling reinforcement of patient tissue structures such as anal sphincters or anastomosed vessel segments.

Abstract: Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.

Abstract: A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. Further, a tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal for compressing the liner outlet and closing any annular assembly clearance at the primary seal for obviating opportunity for seal extrusion under pressure. An axial position in the boss, and dimensional integrity, of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be integral with the boss. Reverse extrusion of the primary seal due to trapped gas and rapid decompression of the cylinder can be defeated by providing a leak path.

Abstract: A sealing system for an outlet of a plastic-lined cylinder has a plastic liner outlet extending into a bore of a boss. An insert is engageable with the bore, forming a primary seal between the insert and portion of the liner outlet. A tapered compression surface of the insert engages a tapered bore portion of the liner outlet adjacent the primary seal forming a tapered interface and a secondary seal. An axial position in the boss, and dimensional integrity, of the liner outlet is maintained by engaging an annular distal end of the liner outlet in the bore by a stop. The stop can be formed on the insert.

Abstract: The embodiments described include graft devices for reinforcing patient tissue structures and methods of making and using the graft devices. In certain embodiments the graft devices have a remodelable extracellular matrix material graft body defining a slot and having a portion receivable through the slot to form a closed loop. Such graft devices can be used in encircling reinforcement of patient tissue structures such as anal sphincters or anastomosed vessel segments.

Abstract: There is disclosed an ultrasound apparatus comprising an ultrasound transducer that operates in a target plane, and a light source that emits a broad, planar light beam that is co-planar with said target plane and directed relative to said ultrasound transducer to illuminate at least a region where an instrument is to be aligned with said target plane.

Abstract: A mass spectrometer for analysis of a sample 5. A laser 1 is provided to illuminate at least part of the surface of the sample 5. Laser light is conducted via an optical fiber 2 and a zoom optical system 3 to the sample. A variable ion optical system 9,10,11 is provided to extract and focus ions released from the sample 5 onto a detector 12. The optical and ion optical systems operate continuously and synchronously to vary the fields of laser illumination and view of the sample such that they are substantially confocal and equal in diameter on the surface of the sample. The sample may be a MALDI sample.

Abstract: There is disclosed an ultrasound apparatus comprising an ultrasound transducer that operates in a target plane, and a light source that emits a broad, planar light beam that is co-planar with said target plane and directed relative to said ultrasound transducer to illuminate at least a region where an instrument is to be aligned with said target plane.

Abstract: Nail care systems in accordance with embodiments of the present invention can include a housing and a nail clipper associated with the housing, the nail clipper having an upper member and a lower member banded by an upper lever and a lower lever. Cutting blades associated with the members can be pinched together by actuating the levers. A container formed between the members can receive nail clippings ejected away from the nail. A nail filer associated with the housing includes a rotatable file that can be used to file nails. This description is not intended to be a complete description of, or limit the scope of, the invention.

Abstract: A memory device includes memory cells, bit lines, active area lines running generally in parallel to the bit lines, and transistors formed in each active area line and electrically coupling memory cells to corresponding bit lines. Each bit line includes slanted portions that intersect a corresponding portion of an active area line at an angle. Contacts electrically coupling the bit line to portions of the active area line are formed in a region generally defined by the angled intersection of the bit line to the active area line. The memory cells can have an area of about 6F2, and the bit lines can be coupled to sense amplifiers in a folded bit line configuration. Each bit line includes a first level portion and a second level portion.

Abstract: A charged particle buncher with a series of spaced apart electrodes 1 arranged to generate a shaped electric field, the series comprising a first electrode 1a, a last electrode 1b and one or more intermediate electrodes, wherein the shaped electric field is generated substantially without free charges being transferred onto or away from the intermediate electrode or electrodes. The first and last electrodes may be connected to means for transferring charged on to or off the electrode. The first, intermediate and last electrodes may be connected in serried with capacitors.