Patents by Inventor Mark E. Wilson

Mark E. Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Azoles as Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators
    Publication number: 20110028514
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Application
    Filed: May 3, 2010
    Publication date: February 3, 2011
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Alex M. Nadzan, Gary D. Lopaschuk, Jason R. Dyck
  • Pyrimidinyl-Thiophene Kinase Modulators
    Publication number: 20100305128
    Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: August 6, 2010
    Publication date: December 2, 2010
    Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie A. Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
  • Fused ring heterocycle kinase modulators
    Patent number: 7829558
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: November 9, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steensma, Mark E. Wilson
  • Pyrimidinyl-thiophene kinase modulators
    Patent number: 7803806
    Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: September 28, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie A. Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
  • Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors
    Patent number: 7786145
    Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: August 31, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Bin Liu, Thomas Arrhenius, Mark E. Wilson, Alex M. Nadzan, Gary D. Lopaschuk, Jason R. Dyck, Rossy Serafimov
  • Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases
    Patent number: 7723366
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: May 25, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Masahiro Nishimoto, David Mark Wallace, Sovouthy Tith, Steve Joel Brown, Charles Stanford Harmon, Gary D. Lopaschuk, Jason R. Dyck
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7709645
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: May 4, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
    Patent number: 7709510
    Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: May 4, 2010
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Thomas Arrhenius, Jie Fei Cheng, Mark E. Wilson, Rossy Serafimov, Alex M. Nadzan, Gary D. Lopaschuk, Jason R. Dyck
  • Fused Ring Heterocycle Kinase Modulators
    Publication number: 20100036118
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 11, 2010
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20090306056
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: July 10, 2009
    Publication date: December 10, 2009
    Inventors: WILLIAM D. ARNOLD, PIERRE BOUNAUD, ANDREAS GOSBERG, ZHE LI, IAN MCDONALD, RUO W. STEENSMA, MARK E. WILSON
  • Fused ring heterocycle kinase modulators
    Patent number: 7626021
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: December 1, 2009
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7601839
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: October 13, 2009
    Assignee: SGX Pharmaceuticals Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7582637
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: September 1, 2009
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • FUSED RING HETEROCYCLE KINASE MODULATORS
    Publication number: 20090203687
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: September 22, 2008
    Publication date: August 13, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steemsma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATIORS
    Publication number: 20090143352
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: April 10, 2007
    Publication date: June 4, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Piperidine Compounds Useful as Malonyl-CoA Decarboxylase Inhibitors
    Publication number: 20090124660
    Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
    Type: Application
    Filed: October 3, 2008
    Publication date: May 14, 2009
    Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHA
    Inventors: Jie Fei Cheng, Mi Chen, Thomas Arrhenius, Mark E. Wilson, Gary D. Lopaschuk, Jason R. Dyck, Rossy Serafimov
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20090005378
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 1, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • Fused ring heterocycle kinase modulators
    Patent number: 7452993
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: November 18, 2008
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steensma, Mark E. Wilson
  • Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors
    Patent number: 7449482
    Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: November 11, 2008
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Jie Fei Cheng, Mi Chen, Thomas Arrhenius, Mark E. Wilson, Gary D. Lopaschuk, Jason R. Dyck, Rossy Serafimov
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20080221119
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: February 29, 2008
    Publication date: September 11, 2008
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Andreas Gosberg, Zhe Li, Ian McDonald, Ruo W. Steensma, Mark E. Wilson