Abstract: The present invention provides previous methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway. In particular, these compounds and pharmaceutical composition containing the same are indicated in the prophylaxis, management and treatment of cardiovascular diseases, diabetes, cancer and obesity.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: The present invention provides methods for the use of compounds as depicted by structure I, pharmaceutical compositions containing the same, and methods for the prophylaxis, management and treatment of metabolic diseases and diseases modulated by MCD inhibition. The compounds disclosed in this invention are useful for the prophylaxis, management and treatment of diseases involving in malonyl-CoA regulated glucose/fatty acid metabolism pathway.

Abstract: The present invention is directed to compositions and methods for increasing the reproductive performance of breeding populations of swine. The swine feed compositions of the present invention are animal feed blends including marine animal products such as a fish oil or fish meal products. Methods include administering to the female swine a biologically effective amount of the swine feed composition comprising marine animal products wherein the marine animal products contain omega-3 fatty acids or esters thereof that serve as a source of metabolites in the female swine, to improve reproductive performance of the female swine.

Abstract: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian, avian, or piscian reproductive sperm cells. The compositions comprise a suitable reproductive cell media and a transforming growth factor, an insulin-like growth factor, or zinc, and, optionally, inositol, transferrin, or fructose, or combinations thereof.

Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.

Abstract: The present invention relates to methods of treatment of certain metabolic diseases, and to the use of compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, the invention relates to the use of compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the following formulae: (I) and (II) Wherein Y, C, R1, R2, R6, and R7 are defined herein.

Abstract: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian, avian, or piscian reproductive sperm cells. The compositions comprise a suitable reproductive cell media and a transforming growth factor, an insulin-like growth factor, or zinc, and, optionally, inositol, transferrin, or fructose, or combinations thereof.

Abstract: Disclosed are compositions for mammalian, avian or piscian reproductive cells and methods for the collection, holding, processing, in vitro fertilization, sexing culturing, or storing (including long-term cryopreservation) of mammalian, avian, or piscian reproductive sperm cells. The compositions comprise a suitable reproductive cell media and a transforming growth factor, an insulin-like growth factor, or zinc, and, optionally, inositol, transferrin, or fructose, or combinations thereof.

Abstract: A panel assembly for transferring fluids from one location to another comprises a panel structure with openings, a nozzle projecting through each opening and a sleeve affixed between the nozzle and its respective opening. Each nozzle includes a tubular portion with a connection end adapted for connection to a transfer conduit. The connection ends of the nozzles are preferably aligned with a common reference plane. Each sleeve has an outer surface with a length that is greater than a combination of a thickness of the panel and any deformity on the panel. With this arrangement, alignment of the connection ends with the common reference plane is independent of any deformity on the panel. A method of constructing a panel assembly includes determining if any defects are present on the inner surface of the tubular portion before installing the nozzle on the panel, and precluding potential inner surface defects during installation of the nozzle on the panel.

Abstract: The present invention is directed to compositions and methods for increasing the reproductive performance of breeding populations of swine. The swine feed compositions of the present invention are animal feed blends including marine animal products such as a fish oil or fish meal products. Methods include administering to the female swine a biologically effective amount of the swine feed composition comprising marine animal products wherein the marine animal products contain omega-3 fatty acids or esters thereof that serve as a source of metabolites in the female swine, to improve reproductive performance of the female swine. The methods can also be used to increase the fertility of a male swine, and can be used to increase the reproductive performance of both male and female animals by feeding the swine feed composition to both the male and female swine.

Abstract: The present invention is directed to compositions and methods for increasing the reproductive performance of breeding populations of swine. The swine feed compositions of the present invention are animal feed blends including marine animal products such as a fish oil or fish meal products. Methods include administering to the female swine a biologically effective amount of the swine feed composition comprising marine animal products wherein the marine animal products contain omega-3 fatty acids or esters thereof that serve as a source of metabolites in the female swine, to improve reproductive performance of the female swine. The methods can also be used to increase the fertility of a male swine, and can be used to increase the reproductive performance of both male and female animals by feeding the swine feed composition to both the male and female swine.

Abstract: A panel assembly for transferring fluids from one location to another comprises a panel structure with openings, a nozzle projecting through each opening and a sleeve affixed between the nozzle and its respective opening. Each nozzle includes a tubular portion with a connection end adapted for connection to a transfer conduit. The connection ends of the nozzles are preferably aligned with a common reference plane. Each sleeve has an outer surface with a length that is greater than a combination of a thickness of the panel and any deformity on the panel. With this arrangement, alignment of the connection ends with the common reference plane is independent of any deformity on the panel. A method of constructing a panel assembly includes determining if any defects are present on the inner surface of the tubular portion before installing the nozzle on the panel, and precluding potential inner surface defects during installation of the nozzle on the panel.

Abstract: A panel assembly for transferring fluids from one location to another comprises a panel structure with openings, a nozzle projecting through each opening and a sleeve affixed between the nozzle and its respective opening. Each nozzle includes a tubular portion with a connection end adapted for connection to a transfer conduit. The connection ends of the nozzles are preferably aligned with a common reference plane. Each sleeve has an outer surface with a length that is greater than a combination of a thickness of the panel and any deformity on the panel. With this arrangement, alignment of the connection ends with the common reference plane is independent of any deformity on the panel. A method of constructing a panel assembly includes determining if any defects are present on the inner surface of the tubular portion before installing the nozzle on the panel, and precluding potential inner surface defects during installation of the nozzle on the panel.

Abstract: A method for estimating two or three location coordinates and/or receiver time offset for a receiver that receives and analyzes timed signals transmitted from one, two or three non-geosynchronous satellites (GPS, GLONASS, modified LEO, etc.). Combinations of pseudorange, Doppler shift and/or first time derivative and/or second time derivative of Doppler shift are determined and used to estimate the location coordinates and/or receiver time offset.

Abstract: A graphical machine-user interface includes a processor connected to a display screen to generate a screen display of individual items in groups together with the selector indication. The processor and a display screen are used to advantage to provide a rich keyboard function from a very limited set of pushbuttons. For example, five pushbuttons indicating "up", "right", "down", "left", and "middle" are recursively used to reduce a large two-dimensional matrix of item choices presented on the display to some subset, e.g., a top, right, bottom, left, or middle subset. If the reduction results in a choice of one, then that item is selected and output automatically. If the reduction results in a subset with more than one item, then a recursive process is used in which the selection process is repeated until the selected subset is reduced to a single item.

Abstract: A non-alcoholic delivery system for active ingredients is disclosed which does not require the use of alcohol as a solvent. Surface acting agents, or surfactants, are used to reduce surface tension of the compound in solution, facilitating dissolution of all additives including non-soluble, spray-dried flavoring oils. Surface acting agents also may produce a foaming or effervescent effect, if desired. One formulation produces a good-tasting, desirable mouthwash with appropriate flavor concentrations, as well as other products.

Abstract: A non-alcoholic effervescent compound for cleaning and disinfecting the mouth, teeth, gums and breath without necessity of alcohol as a solvent. Surface acting agents, or surfactants, are used to reduce surface tension of the compound in solution, facilitating dissolution of all additives including non-soluble oil-containing components. Surface acting agents also produce a foaming effect which loosens bacteria and food off and out from between teeth. The compound eliminates use of alcohol as a solvent, has increased cleaning action from both foaming and effervescence and produces a good-tasting, desirable mouthwash with appropriate flavor concentrations.

Abstract: An unobscured three mirror wide-angle telescopic imaging system comprised of an input baffle which provides a 20.degree. (Y axis).times.30.degree. (X axis) field of view, a primary mirror having a convex spherical surface, a secondary mirror having a concave ellipsoidal reflecting surface, a tertiary mirror having a concave spherical reflecting surface. The mirrors comprise mirror elements which are offset segments of parent mirrors whose axes and vertices commonly lie on the system's optical axis. An iris diaphragm forming an aperture stop is located between the secondary and tertiary mirror with its center also being coincident with the optical axis and being further located at the beam waist of input light beams reflected from the primary and secondary mirror surfaces. At the system focus following the tertiary mirror is located a flat detector which may be, for example, a TV imaging tube or a photographic film.