Abstract: Provided are methods of identifying peptide epitopes of a major histocompatibility complex (MHC) molecule of an antigen, such as a tumor antigen, autoimmune antigen or pathogenic antigen. In some embodiments, the methods relate to using cytomegalovirus containing a nucleic acid molecule encoding the antigen to infect cells under conditions to generate particular peptide epitopes of the antigen. Also provided are methods of identifying peptide binding molecules that bind to a peptide epitope in the context of an MHC molecule. In some embodiments, the peptide binding molecule is a T cell receptor (TCR) or antibody, including antigen-binding fragments thereof and chimeric antigen receptors (CAR) thereof. Also provided are methods of genetically engineering cells containing such peptide binding molecules, and such genetically engineered cells, including compositions and uses thereof in adoptive cell therapy.

Abstract: Provided are methods of identifying peptide epitopes of an antigen recognized by the non-classical major histocompatibility complex (MHC) molecule designated MHC-E. In some embodiments, the antigen is a tumor antigen, autoimmune antigen or pathogenic antigen. Also provided are methods of identifying peptide binding molecules that bind to a peptide in the context of an MHC-E molecule. In some embodiments, the peptide binding molecule is a T cell receptor (TCR) or antibody, including antigen-binding fragments thereof and chimeric antigen receptors (CAR) thereof. Also provided are methods of genetically engineering cells containing such MHC-E-restricted peptide binding molecules, and such genetically engineered cells, including compositions thereof and uses in adoptive cell therapy.

Abstract: Systems and methods of producing video data and/or audio-photos from a static digital image are disclosed. One such method, among others, comprises receiving input from a user indicating sequentially, in real time, a plurality of regions of the static digital image. The method also includes processing the user input to determine the visual content of each of a sequence of video frames and generating output data representative of the sequence of video frames. The sequence and composition of the video frames are determined such that the visual content of the video frames is taken from the static digital image. For each region of the static image indicated by the user, a video frame is composed such that the said region occupies a substantial part of the video frame. The sequence of video frames shows the regions indicated by the user in sequential correspondence with the sequence in which the user indicated the regions and substantially in pace with the time in which the user indicated the regions.

Abstract: An audio photograph data storage system stores a printed image and a plurality of audio segments associated with the printed image. The audio segments are arranged in a plurality of audio layers.

Abstract: An apparatus for Internet browsing and other Internet-interactive activities, comprises: a camera focusing on a printed hypertext document for generating video signals representing an image of the printed hypertext document in electronic form: A processor linked to the camera processes images of the printed hypertext document captured by the camera and a finger or other pointing implement within the camera field of view pointing to a region of the printed hypertext document and determines from the image the identity of a linked web page or a linked multi-media, i.e. audio and/or video sequence, data file referred to on that hypertext document in the region pointed to, and then fetches from the Internet or a local cache of web pages data comprising the linked web page or linked multimedia data file referenced in the printed hypertext document. A receiver receives and displays or plays the fetched data.

Abstract: The present invention provides an elastomeric film having anti-skid properties. The film comprises one or more layers, wherein at least one of the layers comprises from 0.1 to 10% (by weight) of an anti-skid additive, which does not melt, or has a melt temperature greater than 500° F., and has a particle size between 50 and 500 microns. Suitable anti-skid additives may be sand, clay, silica, crosslinked polyethylenes, other polymers or ultra high molecular weight polyethylene (UHMWPE). Also provided is a resin composition and a method for manufacturing an elastomeric film having anti-skid properties.

Abstract: A plastic bag comprising a first face and a second face, at least a portion of each being 2-ply and having an intermediate space therebetween, the 2-ply portion of the first face having an inner layer of air-impervious plastic material having openings therein; the 2-ply portion of the second face having an outer layer of air-impervious plastic material, the outer layer having openings therein permitting air to pass therethrough, the openings of the outer layer having a smaller average opening area than an average opening area of the openings of the inner layer of the first face; and a filtering chamber formed between the inner layer and the outer layer such that air in an interior of the bag may egress the bag by passing through the filtering chamber, the air being at least partially filtered of particulate matter as it egresses the bag.

Abstract: The present invention provides an elastomeric film having anti-skid properties. The film comprises one or more layers, wherein at least one of the layers comprises from 0.1 to 10% (by weight) of an anti-skid additive, which does not melt, or has a melt temperature greater than 500° F., and has a particle size between 50 and 500 microns. Suitable anti-skid additives may be sand, clay, silica, crosslinked polyethylenes, other polymers or ultra high molecular weight polyethylene (UHMWPE). Also provided is a resin composition and a method for manufacturing an elastomeric film having anti-skid properties.

Abstract: The present invention provides a reflective film that can be adhered to a surface of a construction material to form a composite material that is useful as radiant heat insulation in industrial, commercial and residential buildings. The reflective film comprises a layer of Aluminum foil adhered to a surface of a polymer film. Also provided is an alternative in which the reflective film comprises a layer of Aluminum foil adhered to polymer-coated kraft paper. The polymer film or polymer-coated kraft paper composite is formulated such that reflective film may be laminated to the surface of the construction material without the use of an adhesive. Also provided are manufacturing processes for the production of the reflective film, or film composite, and for laminating the film or film composite to the surface of a construction material.

Abstract: An automated method and apparatus for assisting a reader to read a printed or scribed document that cites, directly or indirectly, other information. A camera focuses down on the document for generating video signals representing an image of the document in electronic form, and a processor linked to the camera processes the image of the document captured by the camera, the processor being configured to fetch information from a database when a user, by pointing to a position on the document, selects a position within the image. The document is placed within the field of view of the camera and finger or pointing implement is placed within the field of view of the camera to a selected position on the document. The camera captures an image of the document and of the finger or pointing implement overlying the document.

Abstract: A multi-media photograph album comprises a network of electrical conductors which connect with plural data storage devices storing audio data and/or image data. A user, via a user interface, selectively addresses the data storage devices. The user selects individual sound bites for immediate playback via a speaker in the photo album, or via transmission over a wireless link, for playback through an external audio device, for example a hi-fi system. Image data are retrieved from the data storage devices and sent via a wireless link to an image data storage device, e.g., a personal computer. The data storage device can be embedded within a photograph, or can be a separate data storage device attached to the album.

Abstract: A passage of sound is attached to a printed image 11 by means of an electronic storage medium 12. The electronic storage medium 12 comprises a die 16 containing a non-volatile memory and a flexible substrate 14 with connectors 15. The connectors can be interfaces with a separate reader 4 which plays the passage of sound recorded in the electronic storage medium. Further information is also provided in the electronic storage medium 12 memory. This further information relates to the printed image. Such information may include a version of the image printed, either to the same or to a lower resolution. It may also include information relating to image capture conditions or location, or information allowing referencing or indexing of the image.

Abstract: The present invention relates generally to methods for activating and expanding T cells, and more particularly, to methods for restoring hematologic function and/or accelerating hematologic recovery in patients by administering said T cells. Compositions of cells activated and expanded by the methods herein are further provided.

Abstract: A storage apparatus for sentimental electronic memorabilia includes a memory and processor for the storage and manipulation of files within which memorabilia is stored, and a monitor for assimilating the memorabilia; in the case of visually assimilable files, the monitor is a visual monitor. Each file is associated with an artefact which acts as a vehicle for the establishment of sentimental links to electronically stored information. The artefacts are stored within a box which also houses the monitor and processor. The association of artefacts with files is through the provision of an rf tag identifier on the artefact. Once the identifier is read by an rf tag reader on the box, the file corresponding to the identifier is retrieved from the memory and furnished to a user in an assimilable form by means of the monitor.

Abstract: A method of associating hand written notes with a stored data set, comprising using a data processor to access the data set, making meaningful hand-written notes, reading and storing images of those notes linked to a record of the state of the data processor when accessing the data set; repeating the process for multiple data sets; then retrieving and reproducing some or all of the associated notes linked with any data set currently being accessed by the data processor, by addressing the record with the current state of the data processor.

Abstract: The present invention provides an elastomeric film having anti-skid properties. The film comprises one or more layers, wherein at least one of the layers comprises from 0.1 to 10% (by weight) of an anti-skid additive, which does not melt, or has a melt temperature greater than 500° F., and has a particle size between 50 and 500 microns. Suitable anti-skid additives may be sand, clay, silica, crosslinked polyethylenes, other polymers or ultra high molecular weight polyethylene (UHMWPE). Also provided is a resin composition and a method for manufacturing an elastomeric film having anti-skid properties.

Abstract: A camera comprising means for capturing an image, integral scent association means operable by a user to associate a scent with the image, and integral means operable to cause the said scent to be perceived by a user. The invention also provides a printer comprising printing means and integral scent generation means, wherein the scent generation means comprise a drive mechanism and a tape having a plurality of scented regions, the drive mechanism being operable to spool the tape and the scent generation means being operable to cause a selected scented region to emit its scent.

Abstract: An audio photograph data storage system stores a printed image and a plurality of audio segments associated with the printed image. The audio segments are arranged in a plurality of audio layers.

Abstract: A printed document is an interface with a computer. A camera generates a video signal representing an image of the printed document. A processor linked to the camera processes an image of the printed document and a finger or pointing implement pointing to a region of the printed document. The processor recognizes when a graphical user interface element within the captured image is selected by the user pointing to the user interface element on the printed document by determining the region on the page that is pointed to by the finger or pointing implement and determining from a memory the identity of the user interface element, if any, that corresponds to the region of the printed page pointed to by the finger or pointing implement and then triggers an operation represented by that graphical user interface element.

Abstract: A multi-media photograph album comprises a network of electrical conductors which connect with plural data storage devices storing audio data and/or image data. A user, via a user interface, selectively address the data storage devices. The user selects individual sound bites for immediate playback via a speaker in the photo album, or via transmission over a wireless link, for playback through an external audio device, for example a hi-fi system. Image data are retrieved from the data storage devices and sent via a wireless link to an image data storage device, e.g., a personal computer. The data storage device can be embedded within a photograph, or can be a separate data storage device attached to the album.