Abstract: A sensory system (10, 100) for improving and/or restoring sensation to a foot or hand of a patient. The system (10, 100) includes at least one force sensor (12, 102) implanted subcutaneously within a finger or palm of a hand or on a plantar surface of a foot of a patient and a base unit (18, 104) that is worn externally by the patient or is implanted subcutaneously in the patient. The force sensor (12, 102) is configured to transmit wireless communication signals to the base unit (18, 104) in response to and concerning forces sensed by the force sensor, and base unit (18, 104) is configured to apply peripheral nerve stimulation based on the wireless communication signals received from the force sensor (12) or to transmit the sensory data to a separate neural implant (106). The force sensor (12, 102) transmits the wireless communication signals to the base unit (18, 104) by magnetic human body communication (mHBC).

Abstract: A seal assembly for a battery cell includes a grommet having an opening having an inner surface. A nail has a nail head and a stem extending from the stem. The stem includes a first portion with a larger diameter and a second portion with a smaller diameter and the stem extends through the opening in the grommet. The stem and the grommet form a first interference fit at a distal end of the opening. A trap clearance is formed between the distal end of the opening and the nail head. The trap clearance defines a trap for a sealant. A sealant is disposed on the stem and is located at least partially in the trap.

Abstract: Wireless sensors configured to sense, record and transmit data are provided herein. In one aspect, the wireless sensor has a power harvesting unit; a transducing A-to-D converter unit, a microcontroller unit, and a transmitting coil. The power harvesting unit is configured to receive an external energizing magnetic field generated by an external interrogator and store the energy generated thereby. The transducing A-to-D converter unit has a passive electrical transducer configured to respond to variations in a physical property and a converter configured to measure a characteristic value of the passive electrical transducer and provide a digital signal that is indicative of the measured characteristic value. The microcontroller unit is electrically coupled to the power harvesting unit and the transducing A-to-D converter unit and is configured to receive the digital signal from the transducing A-to-D converter unit.

Abstract: A method and system for adjusting the spatial accuracy of one or more address records by comparing the situs addresses of parcel records to the physical addresses of the address records, comparing the landowner names of parcel records to the personal names of the address records, and comparing the spatial coordinates of the address record to the spatial coordinates for the centroids of parcel records.

Abstract: Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.

Abstract: Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility.

Abstract: Wireless sensors configured to sense, record and transmit data are provided herein. In one aspect, the wireless sensor has a power harvesting unit; a transducing A-to-D converter unit, a microcontroller unit, and a transmitting coil. The power harvesting unit is configured to receive an external energizing magnetic field generated by an external interrogator and store the energy generated thereby. The transducing A-to-D converter unit has a passive electrical transducer configured to respond to variations in a physical property and a converter configured to measure a characteristic value of the passive electrical transducer and provide a digital signal that is indicative of the measured characteristic value. The microcontroller unit is electrically coupled to the power harvesting unit and the transducing A-to-D converter unit and is configured to receive the digital signal from the transducing A-to-D converter unit.

Abstract: Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Abstract: Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Abstract: An optical device for integrated photonic applications includes a substrate, a dielectric waveguide and a surface plasmon waveguide. The dielectric waveguide includes a dielectric waveguide core disposed relative to a dielectric waveguide cladding and a common cladding. The surface plasmon waveguide includes a surface plasmon waveguide core disposed relative to the common cladding and a surface plasmon waveguide cladding. The common cladding couples the dielectric waveguide and the surface plasmon waveguide.

Abstract: Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.

Abstract: The present invention comprises methods and devices for thermal treatment of a barrier to increase the permeability of the barrier. One form of increasing the permeability of the barrier comprises forming micropores which may be used for administration of active agents across the barrier, or may be used for sampling or collecting fluids, or may be used for detecting, measuring or determining analytes, or may be used for monitoring of physiological or other conditions. Devices of the present invention may comprise microheaters that are activated by inductive or ohmic heating power supply components.

Abstract: Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer.

Abstract: Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle.

Abstract: Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Abstract: Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna.

Abstract: Simple microneedle devices for delivery of drugs across or into biological tissue are provided, which permit drug delivery at clinically relevant rates across or into skin or other tissue barriers, with minimal or no damage, pain, or irritation to the tissue. The devices include a substrate to which a plurality of hollow microneedles are attached or integrated, and at least one reservoir, containing the drug, selectably in communication with the microneedles, wherein the volume or amount of drug to be delivered can be selectively altered. The reservoir can be formed of a deformable, preferably elastic, material. The device typically includes a means, such as a plunger, for compressing the reservoir to drive the drug from the reservoir through the microneedles, In one embodiment, the reservoir is a syringe or pump connected to the substrate.

Abstract: Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold.

Abstract: An electromagnetically coupled hermetic chamber includes a body defining a hermetic chamber. A distributed LC circuit is disposed within the hermetic chamber and a second conductive structure is attached to the body outside of the hermetic chamber. The distributed LC circuit is electromagnetically coupled to the second conductive structure without direct electrical paths thereby allowing coupling of the distributed LC circuit to external electronics without the need for electrical feedthroughs or vias that could compromise the integrity of the hermetic chamber.

Abstract: An electromagnetically coupled hermetic chamber includes a body defining a hermetic chamber. A first conductive structure is disposed within the hermetic chamber, and a second conductive structure is attached to the body outside of the hermetic chamber. The first conductive structure is electromagnetically coupled to the second conductive structure without direct electrical paths connecting the first and second conductive structures. Thus the first conductive structure can be coupled to external electronics without the need for electrical feedthroughs or vias that could compromise the integrity of the hermetic chamber.