Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Disclosed herein are compositions including a thermoformable sheet having three of more layers. Two layers include one or more monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, one or more monovinylidene aromatic monomer and unsaturated nitrile containing copolymers, or a blend of one or more monovinylidene aromatic monomer containing polymers and a polyolefin, which exhibit resistance to environmental stress cracking. At least one of the two layers is an outer layer. An inner layer includes post-consumer recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, post-industrial recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include virgin monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include an outer layer which is a gloss layer.

Abstract: A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.

Abstract: An apparatus for sputtering target material onto a substrate based on a plasma confining racetrack having two parallel straight portions and two turnaround portions includes a tubular target, an elongated magnet array, and a drive mechanism. The tubular target has two ends in proximity to the two turnaround portions and a longitudinal axis about which the target is rotatable. The magnet array is supported within the target to generate a plasma-confining magnetic field. The array includes a central stationary portion of magnets and two axially movable shunts positioned at the ends of the stationary portion. Each shunt carries a magnet segment configured to slidably extend from each end of the stationary portion to define a gap. The gaps are positioned internal to the turnaround portions. The drive mechanism axially moves the shunts parallel to the longitudinal axis of the target to vary a width of the gaps.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A composition includes one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds containing nucleophilic groups, and the copolymer has on average about 0.01 to about 15.0 percent by weight of nucleophilic groups pendant from the copolymer. The copolymer is chain extended and/or branched by one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds having electrophilic groups, or a portion of the chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups are crosslinked with other chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups by ionic bonding of anions formed from the pendant nucleophilic groups with a metal cation having a valence of 2 or greater or complexation between pendant acid groups and metal oxides.

Abstract: This invention provides protein stabilizing compounds, compositions, and methods of use thereof, that include a USP7 Targeting Ligand, a Protein Targeting Ligand, and optionally a Linker for the restoration of a Target Ubiquitinated Protein to treat a disorder mediated by deficiencies of the Target Protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Example illustrations are directed to a suspension system for a vehicle and methods. In some examples, a controller of a suspension system is configured to determine the vehicle is in a service environment, and to set a height precision mode for the suspension system based on the determination the vehicle is in the service environment. In some examples, the controller is configured to detect a suspension operating condition of the vehicle, and to change a setting associated with the suspension system based on the suspension operating condition. An example method comprises detecting, using a controller, a suspension operating condition of a suspension system of a vehicle. The method may further include changing, using the controller, a setting associated with the suspension system based upon the suspension operating condition.

Abstract: A composition includes one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds containing nucleophilic groups, and the copolymer has on average about 0.01 to about 15.0 percent by weight of nucleophilic groups pendant from the copolymer. The copolymer is chain extended and/or branched by one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds having electrophilic groups, or a portion of the chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups are crosslinked with other chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups by ionic bonding of anions formed from the pendant nucleophilic groups with a metal cation having a valence of 2 or greater or complexation between pendant acid groups and metal oxides.

Abstract: A sensor for detecting a target analyte in a sample includes a pair of conducting electrodes that are separated by a gap. An insulator is disposed in the gap between the electrodes. Plural wells are defined by one of the electrodes and the insulator, to expose the other of the electrodes. The wells are configured to receive a sample including a target analyte. The target analyte, when present in the sample received in the wells, modulates an impedance between the electrodes. The modulated impedance, which is measurable with an applied electrical voltage, is indicative of the concentration of the target analyte in the sample. The wells can include antibodies immobilized inside the wells, to bind the target analyte, which can be a cytokine. Also provided are a method for label-free sensing of a target analyte in a sample, and a transcutaneous impedance sensor for label-free, in-situ biomarker detection.

Abstract: The subject matter described herein relates to laminated magnetic cores, methods of fabricating laminated magnetic cores, and electric devices using laminated magnetic cores. In some examples, a method for fabricating a laminated magnetic core includes depositing a first magnetic layer and depositing an interlamination layer of over the first magnetic layer. The interlamination layer comprises a partially conducting material having a conductivity greater than or equal to 10?4 S/cm and less than or equal to 105 S/cm. The method includes depositing a second magnetic layer over the interlamination layer. The method can include sequentially depositing additional interlamination layers and additional magnetic layers in an alternating fashion to produce the laminated magnetic core.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: FDisclosed herein are compositions including a thermoformable sheet having three of more layers. Two layers include one or more monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, one or more monovinylidene aromatic monomer and unsaturated nitrile containing copolymers, or a blend of one or more monovinylidene aromatic monomer containing polymers and a polyolefin, which exhibit resistance to environmental stress cracking. At least one of the two layers is an outer layer. An inner layer includes post-consumer recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, post-industrial recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include virgin monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include an outer layer which is a gloss layer.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: A winch system for a vehicle is provided herein. The winch system includes a winch assembly that is coupled to a body. A sensor system is configured to monitor the winch assembly. A controller processes information from the sensor system. The controller is configured to determine a duration of use and service condition of the winch assembly. The controller is also configured to determine an unauthorized condition based on tampering. The controller is further configured to determine an operational condition from at least one of the service condition and the unauthorized condition. A display generates a visual message when the controller determines the operational condition.