Abstract: The subject matter described herein relates to laminated magnetic cores, methods of fabricating laminated magnetic cores, and electric devices using laminated magnetic cores. In some examples, a method for fabricating a laminated magnetic core includes depositing a first magnetic layer and depositing an interlamination layer of over the first magnetic layer. The interlamination layer comprises a partially conducting material having a conductivity greater than or equal to 10?4 S/cm and less than or equal to 105 S/cm. The method includes depositing a second magnetic layer over the interlamination layer. The method can include sequentially depositing additional interlamination layers and additional magnetic layers in an alternating fashion to produce the laminated magnetic core.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: FDisclosed herein are compositions including a thermoformable sheet having three of more layers. Two layers include one or more monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, one or more monovinylidene aromatic monomer and unsaturated nitrile containing copolymers, or a blend of one or more monovinylidene aromatic monomer containing polymers and a polyolefin, which exhibit resistance to environmental stress cracking. At least one of the two layers is an outer layer. An inner layer includes post-consumer recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber, post-industrial recycled monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include virgin monovinylidene aromatic monomer containing polymers which are impact modified by a rubber. Optionally, the composition may include an outer layer which is a gloss layer.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: A winch system for a vehicle is provided herein. The winch system includes a winch assembly that is coupled to a body. A sensor system is configured to monitor the winch assembly. A controller processes information from the sensor system. The controller is configured to determine a duration of use and service condition of the winch assembly. The controller is also configured to determine an unauthorized condition based on tampering. The controller is further configured to determine an operational condition from at least one of the service condition and the unauthorized condition. A display generates a visual message when the controller determines the operational condition.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: A method of controlling power delivered to a shape memory alloy, SMA, actuator wire arrangement, wherein the arrangement comprises a plurality of SMA actuator wires, comprising: the steps of: applying, at a PWM frequency, to each of the SMA actuator wires during respective active periods a succession of voltage pulses; and applying, during a resistance measurement period, to one of the plurality of SMA actuator wires a resistance measurement current pulse, wherein the resistance measurement period corresponds to the respective active period of one of the plurality of SMA actuator wires.

Abstract: The subject matter described herein relates to laminated magnetic cores, methods of fabricating laminated magnetic cores, and electric devices using laminated magnetic cores. In some examples, a method for fabricating a laminated magnetic core includes depositing a first magnetic layer and depositing an interlamination layer of over the first magnetic layer. The interlamination layer comprises a partially conducting material having a conductivity greater than or equal to 10?4 S/cm and less than or equal to 105 S/cm. The method includes depositing a second magnetic layer over the interlamination layer. The method can include sequentially depositing additional interlamination layers and additional magnetic layers in an alternating fashion to produce the laminated magnetic core.

Abstract: Compounds and compositions that have a Protein Recognition Moiety bound to an electrophile for the selective covalent modification of targeted proteins to treat disorders mediated by the targeted protein are described.

Abstract: Extracellular protein degraders and compositions are provided that have a potent asialoglycoprotein receptor (ASGPR) Binding Ligand bound to an Extracellular Protein Targeting Ligand for the selective degradation of the Target Extracellular Protein, for example immunoglobulin in vivo to treat disorders mediated by the extracellular protein.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: Heteroaryl sulfonyl compounds and compositions that have a KRAS Recognition Moiety bound to an electrophile for the selective covalent modification of KRAS, for example a mutant KRAS, to treat KRAS-mediated disorders are described.

Abstract: Heteroaryl sulfonyl compounds and compositions that have a CDK2 Recognition Moiety bound to an electrophile for the selective covalent modification of CDK2 to treat CDK2-mediated disorders are described.

Abstract: Methods and systems for producing metal/polymer multilayer microstructures. In some examples, a method includes method for fabricating a multilayer microstructure using sequential multilayer deposition. This method includes deposition of an active metal containing desired physical, mechanical, and/or electrical properties, followed by the deposition of a protective layer of an inert metal. Subsequently, a polymer layer is deposited in which the deposition bath chemistry and conditions are optimized to control the growth direction and rate of the polymerization and thus the morphology of the layer. This is defined as the morphological polymer layer. A film of the same polymer with different polymerization conditions is then deposited such that a proper interface for subsequent metal deposition is created; this is the interfacial polymer layer. Lastly, the interfacial polymer layer is activated by deposition of a thin pure metal on the surface, creating an optimal substrate for the next active metal layer.

Abstract: Compounds and compositions that have an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein are described.

Abstract: The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.

Abstract: The present invention relates to systems for providing noninvasive cranial nerve stimulation and methods for using the same. The present invention administers therapy through electrodes that are noninvasively attached to one or more of a subject’s cranial nerve. The systems can be used to enhancing rehabilitation and recovery by improving neuroplasticity and coupling muscle training with feedback.

Abstract: A pressure sensor assembly includes a pressure sensor, a pedestal and an electrically conductive header having a header cavity. The pressure sensor includes, an electrically conductive sensing layer having a sensor diaphragm, an electrically conductive backing layer having a bottom surface that is bonded to the sensing layer, an electrically insulative layer having a bottom surface that is bonded to a top surface of the backing layer, and a sensor element having an electrical parameter that changes based on a deflection of the sensor diaphragm in response to a pressure difference. The pedestal is bonded to the electrically insulative layer and attached to the header within the header cavity.