Abstract: The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.

Abstract: A stimulation system for a patient is provided. The system comprises: at least one implantable device comprising at least one implantable antenna; and an external device comprising at least one external antenna, wherein the at least one external antenna transfers power to the at least one implantable antenna. The at least one implantable device delivers therapy to the patient. A patient attachment device or body covering positions the at least one external antenna relative to the patient.

Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Abstract: An ultrasonic mechanical defect and/or fault detection and monitoring system includes at least one ultrasonic fault detection device configured to measure ultrasonic emissions from an object under evaluation and to generate an output signal in response thereto. The system further includes at least one processor configured by code to receive the generated output signal; access a library of stored signal patterns; compare the generated output signal against the library of stored signal patterns; and generate an alert where the generated output signal matches at least one of the library of stored signal patterns.

Abstract: An ultrasonic mechanical defect and/or fault detection and monitoring system includes at least one ultrasonic fault detection device configured to measure ultrasonic emissions from an object under evaluation and to generate an output signal in response thereto. The system further includes at least one processor configured by code to receive the generated output signal; access a library of stored signal patterns; compare the generated output signal against the library of stored signal patterns; and generate an alert where the generated output signal matches at least one of the library of stored signal patterns.

Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Abstract: An apparatus and method for washing and drying objects includes a rotating washing fluid sprayer having several nozzles to direct washing fluid, e.g., water, at an object being washed in a chamber. A drying fluid is directed at the object in the chamber to dry the object. The drying fluid, e.g., air, is directed in a spiral pattern against the object to urge washing liquid away from the object to dry the object and to push the drying liquid away from edges of the object. The air may be directed at the object simultaneously with the water to increase the energy with which the water impinges on the object and to urge dirt from the object being washed.

Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Abstract: This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate, wherein the conjugate comprises a thiomaltose-based analog and a molecule of interest under conditions such that the conjugate is transported across the bacterial cell wall. In certain embodiments, the molecule of interest can be a tracer or an antibiotic.

Abstract: The present invention is directed an ultrasonic frequencies fault detecting apparatus. The present invention uses high frequency ultrasonic energy signals to analyze bearings and determine the presence of faults therein. The ultrasonic return signals are heterodyned (by amplitude demodulation) into the audio spectrum for purposes of audio detection. In addition, a FFT spectrum of the signal is displayed on a monitor for more accurate results. According to the present invention software is used to automatically analyze the FFT spectrum by comparing the current spectrum with stored spectrums of known bearing conditions as modified based on the rotary speed of the bearing and the number of balls. Once a defect in a bearing has been located in this manner using automated FFT analysis, an operator can then use a device, such as a calibrated lubricant dispenser, to effectuate maintenance and/or repair.

Abstract: Methods and systems are provided for auto-optimization of gamification mechanics. A gamification platform, hosted on any suitable interface, may collect action data from one or more employee. Gamification mechanics are applied to the actions to compute an effectiveness value for each action. An optimization layer of the system may receive performance metrics for the employee from internal systems, or via third party systems. The performance metrics may be employed to update the gamification mechanics by optimizing weights for each action in a fitness function. Effectiveness predictions for future actions are generated using these optimized weights. The updated mechanics and predictions may be provided back to the gamification platform to iteratively repeat the process.

Abstract: This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.

Abstract: A lubrication dispensing apparatus for lubricating a device with moving parts includes a lubricant reservoir, a lubricant dispenser for dispensing lubricant from the lubricant reservoir, an ultrasonic detection module which detects the amplitude of ultrasonic energy emitted by said device when its parts are moving and produces an signal related thereto, and a control module which analyzes the amplitude of the signal from the ultrasonic detection module and, in response to a lubricate signal, causes the lubricant dispenser to automatically dispense lubricant onto the moving parts of the device until the signal from the ultrasonic detector indicates that the ultrasonic energy produced by the device has decreased to a particular level. The control module includes a programmed processor and a storage memory. The memory stores as a base value the value of the detected amplitude of ultrasonic energy when the device is operating properly.

Abstract: An improved method for dividing and distributing the work of an arbitrary algorithm, having a predetermined stopping condition, for processing by multiple computer systems. A scheduler computer system accesses a representation of a plurality of work units, structured as a directed graph of dependent tasks, then transforms that graph into a weighted graph in which the weights indicate a preferred path or order of traversal of the graph, in turn indicating a preferred order for work units to be executed to reduce the impact of inter-work unit dependencies. The scheduler computer system then assigns work units to one or more worker computer systems, taking into account the preferred order.

Abstract: A base computer system obtains a set of definitions of calculations to be performed, and periodically monitors a data store to see if the data required for the calculations are available. When the required data for a given calculation are available, the base computer system sends the data and calculation instructions to a group of one or more remote computer systems for execution. The remote computer systems may be equipped with Graphics Processing Units (GPUs) for high-performance computation. The base computer system then awaits the return of reports from the one or more remote computer systems.

Abstract: This invention relates to a machine implemented method of executing CPU instructions on a plurality of computers in one or more locations, logically arranged in a weighted, lattice-like structure representing information about CPUs, CPU cores, operating system threads, network interconnects, and computer locations in a many-to-many relationship. This approach, by weighting nodes and costing edges, provides a natural method for commoditizing the execution of a workload. Furthermore, this approach lends itself to a means of determining the incremental value (or cost) of additional nodes. Consequently, the creation of a virtual crowd-sourcing market—in which either CPUs singularly or lattices as a whole are market participants—is a natural extension of the method.

Abstract: A portable apparatus for determining testing the condition of a machine or device using ultrasonic signals with an array of ultrasonic sensors for receiving an ultrasonic signal transmitted from the machine or device. The apparatus possesses a heterodyne circuit coupled to receive the output signals from the ultrasonic sensors and convert the output signals to a heterodyned audio signal to be analyzed via a digital spectrum analyzer integral to the portable apparatus. The digital spectrum analyzer performs real-time fast fourier transformations on the heterodyned audio signal. After analyzing the signals, the hand held device uses a variety of audiovisual cues to direct a user to portions of the machine in need of repair or monitoring.

Abstract: Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).