Abstract: This invention provides heterocyclic compounds that bind to E3 Ubiquitin Ligase (typically through cereblon) (“Degrons”), which can be used as is or linked to a Targeting Ligand for a selected Target Protein for therapeutic purposes and methods of use and compositions thereof as well as methods for their preparation.

Abstract: A reel based tensioning device includes a housing, a spool that is rotatably positioned within the housing, and a knob member that is operably coupled with the spool to cause the spool to rotate in a first direction within the housing and thereby wind a tension member about the spool. The reel based tensioning device also includes a load holding mechanism that is coupled with the spool and that is configured to rotate the spool in the first direction within the housing and to prevent rotation of the spool in a second direction to prevent unwinding of the tension member from about the spool. The reel based tensioning device further includes an audible component that is configured to produce an audible noise responsive to operation of the knob member to signal an adjustment of the tension member.

Abstract: Systems and apparatus are provided for a high-power microwave sensor using an unmanned aerial vehicle. The unmanned aerial vehicle may include a central body, at least one electric motor, and a barometric pressure feedthrough. The central body may include a first enclosure housing a plurality of low voltage components, a voltage feedthrough connector, and a second enclosure housing a plurality of high voltage components. The low voltage components may include a first signal processing system, a first radio transceiver, a flight controller, a second signal processing system, a second radio transceiver, and a navigation system. The high voltage components may include a plurality of electronic speed controllers, a power distribution module, an input power interface, and a plurality of high power filters. The components of each enclosure may be segregated such that the high voltage components do not create electromagnetic interference with the low voltage components.

Abstract: Disclosed herein is an adjustable shoring beam in which the ends can adjusted to different heights along one or more securement tracks on a vertical post. The adjustable shoring beam engages the securement tracks on the vertical posts and each end is independently adjustable in one degree of freedom. Modular deck tracks on the vertical posts, adjacent to the securement tracks, allow for the engagement of a modular deck with a vertical post. The modular deck and securement beam are able to be moved independently past each other on the vertical posts by a user or an autonomous machine.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: A method and system for detecting and avoiding an obstacle of an autonomous unmanned maritime vehicle (UMV) traveling in an initial direction are described. The method and system include receiving a video image from at least one image sensor, the video image containing an object that has been identified as an obstacle, determining if the object can be associated with an object class from the plurality of predetermined object classes, accessing a mean height value for the object class if it determined that the object can be associated with an object class from the plurality of predetermined object classes, determining a distance between the UMV and the object based on a height of the object as displayed in the video image and the mean height for the object class, and automatically adjusting the navigational control of the autonomous UMV to travel in an adjusted direction.

Abstract: An acoustic system is disclosed. The acoustic system includes a sound absorptive substrate, and a rigid polyester shell configured to be positioned over the sound absorptive substrate. The rigid polyester shell is configured to be mounted on an interior surface of a building such that at least some sound waves pass through the rigid polyester shell. The shell is configured to provide aesthetic features to the acoustic system.

Abstract: Systems and apparatus are provided for a high-power microwave sensor using an unmanned aerial vehicle. The unmanned aerial vehicle may include a central body, at least one electric motor, and a barometric pressure feedthrough. The central body may include a first enclosure housing a plurality of low voltage components, a voltage feedthrough connector, and a second enclosure housing a plurality of high voltage components. The low voltage components may include a first signal processing system, a first radio transceiver, a flight controller, a second signal processing system, a second radio transceiver, and a navigation system. The high voltage components may include a plurality of electronic speed controllers, a power distribution module, an input power interface, and a plurality of high power filters. The components of each enclosure may be segregated such that the high voltage components do not create electromagnetic interference with the low voltage components.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: An acoustic system is disclosed. The acoustic system includes a number of acoustic panel sections having a variety of acoustic properties. Each acoustic panel section is configured to be mounted on an interior surface of a building and cooperates with the other acoustic panel sections to define a pattern on the interior surface of the building.

Abstract: Described are methods of estimating a physical property associated with a region of a sports article. The method includes determining a plurality of structural features within the region, determining, for each structural feature, a feature value, mapping each feature value to a physical property, wherein the mapping is based on a machine learning algorithm from a limited plurality of samples, and wherein each sample associates a feature value with a value of the physical property, and using the mapping to estimate the physical property for the region.

Abstract: The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: An acoustic system is disclosed. The acoustic system includes a number of acoustic panel sections having a variety of acoustic properties. Each acoustic panel section is configured to be mounted on an interior surface of a building and cooperates with the other acoustic panel sections to define a pattern on the interior surface of the building.

Abstract: A pool filter system includes a filter housing with an open interior. A pleated filter container in the open interior of the filter housing has a pleated filter side wall and divides the interior of the filter housing into an pleated filter compartment and an particulate filter compartment surrounding the pleated filter side wall. The pleated filter side wall has a plurality of pleated filter container openings. A particulate filter medium is within the particulate filter compartment, and a pleated filter is within the open interior of the pleated filter compartment. A water inlet communicates with the particulate filter compartment, and a water outlet communicates with the pleated filter compartment. The pleated filter container openings in the pleated filter container side wall have a dimension that is less than the diameter of the particulate filter medium. A backwash assembly and a method of filtering pool water is also disclosed.

Abstract: Slew drive systems for rotational and axial load bearing, e.g., in applications including satellite-based telecommunications systems, are disclosed herein. In some cases, slew drive systems disclosed herein can improve efficiency, accuracy, and/or reliability of telecommunication systems while reducing the cost and complexity of manufacture. For example, a slew drive system can comprise a threaded plug and a retaining ring in addition to a worm gear, a plurality of tapered roller bearings, and a worm wheel, allowing a significant reduction in material and labor costs of slew drive manufacture, which can be critical in the manufacture of expensive telecommunications system actuator assemblies.

Abstract: A document handler system and method includes timed operation functionality in which the manufacturer of the document handler may input coded information in the document handler to establish a timed operation of the document handler which may be contingent on continued payments for use of the document handler. Alternatively, or in addition, the timed operation may be used to establish an appropriate warranty period during which the manufacturer is obligated to provide repairs, modification and/or support for the document handler.