Patents by Inventor Mark Huang

Mark Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200054765
    Abstract: Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 20, 2020
    Inventors: Zhi-Yong YANG, Gary J. NABEL, Ling XU, Ronnie WEI, Huawei QIU, Jochen BENINGA, Jochen KRUIP, Ercole RAO, Wulf Dirk LEUSCHNER, Christian BEIL, Christian LANGE, Mark CONNORS, John R. MASCOLA, Richard A. KOUP, Jinghe HUANG, Nicole A. DORIA-ROSE, Tongqing ZHOU, Peter D. KWONG, Young Do KWON, Amarendra PEGU, Mangaiarkarasi ASOKAN
  • Patent number: 10562960
    Abstract: Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 18, 2020
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Mark Connors, Jinghe Huang, Byong Ha Kang, John Mascola, Elise Ishida, Tongqing Zhou, Peter Kwong, Anqi Zheng
  • Patent number: 10556329
    Abstract: A tool bit assembly includes a tool bit having a shaft with a first working region disposed at a first end of the shaft and a first reduced diameter portion proximate the working region and disposed between a first shoulder and a second shoulder. A floating sleeve has a rear portion with a pair of opposed window openings, a front portion supporting a magnet, and a pair of balls, with each ball disposed in one of the window openings. The floating sleeve is receivable over the tool bit with the magnet proximate the first working regions and the balls received in the first reduced diameter portion to allow the floating sleeve to move between a first position in which the balls abut the first shoulder and a second position in which the balls abut the second shoulder.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: February 11, 2020
    Assignee: BLACK & DECKER INC.
    Inventors: Michael P. Peters, Denny Jiang, Michael Huang, Darren B. Moss, Aland Santamarina, David B. Lee, Mark E. Brunson, Ruth E. Mitchener Keffer
  • Publication number: 20200039914
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, A, W, L, Ra, and G are defined herein: and by Formula (II) as follows: wherein R1B, WB, LB, , and GB are defined herein.
    Type: Application
    Filed: October 24, 2017
    Publication date: February 6, 2020
    Inventors: Hui Huang, James C. Lanter, Sanath K. Meegalla, Mark R. Player
  • Publication number: 20200029927
    Abstract: Systems and methods for determining body composition by combining dual-energy x-ray (DXA) technology with three-dimensional (3D) optical technology and/or bioimpedance technology. A multi-modality scanning system may include a dual-energy x-ray source and an x-ray detector mounted to opposing sides a c-arm and configured to scan a patient on a optically translucent table. The system may also include one or more 3D optical imaging devices to capture 3D optical images of the patient substantially concurrently with the emission of the dual energy x-rays. A bioimpedance machine may also be included in the multi-modality scanning system. Data based on the dual-energy x-rays may be combined with the data from the 3D optical images and/or the bioimpedance data to generate values of at least three compartments selected from: bone, fat tissue, lean tissue, dehydrated lean tissue, and water.
    Type: Application
    Filed: March 22, 2018
    Publication date: January 30, 2020
    Inventors: Kevin E. WILSON, John A. SHEPHERD, Bennett K. NG, Mark GUETERSLOH, Chao HUANG, Thomas L. KELLY, Wei WANG, Howard WEISS
  • Publication number: 20200031692
    Abstract: An electrode for use in bio-electrochemical systems is described, including: a substantially planar electrode material; a frame comprising a non-conductive substance; and one or more first conductive substances linked or secured to the frame. Bio-electrochemical systems, racks for inserting the electrode, and methods of using the racks are also described.
    Type: Application
    Filed: August 5, 2019
    Publication date: January 30, 2020
    Applicant: Cambrian Innovation, Inc.
    Inventors: Matthew Silver, Justin Buck, Casey Chartier, Mark Barosky, James Ryan Hawkins, Zhen Huang, Quynh Anh Le Tran, Tzipora Wagner
  • Patent number: 10546306
    Abstract: Methods, apparatuses, computer program products, devices and systems are described that carry out accepting at least one persona from a party to a transaction; evaluating the transaction; and negotiating receipt of at least one different persona from the party to the transaction at least partly based on an evaluation of the transaction.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: January 28, 2020
    Assignee: Elwha LLC
    Inventors: Marc E. Davis, Matthew G. Dyor, William Gates, Xuedong Huang, Roderick A. Hyde, Edward K. Y. Jung, Jordin T. Kare, Royce A. Levien, Richard T. Lord, Robert W. Lord, Qi Lu, Mark A. Malamud, Nathan P. Myhrvold, Satya Nadella, Daniel Reed, Harry Shum, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 10546295
    Abstract: Methods, apparatuses, computer program products, devices and systems are described that carry out accepting at least one request for personal information from a party to a transaction; evaluating the transaction; and negotiating presentation of at least one persona to the party to the transaction at least partly based on an evaluation of the transaction.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: January 28, 2020
    Assignee: Elwha LLC
    Inventors: Marc E. Davis, Matthew G. Dyor, William Gates, Xuedong Huang, Roderick A. Hyde, Edward K. Y. Jung, Jordin T. Kare, Royce A. Levien, Richard T. Lord, Robert W. Lord, Qi Lu, Mark A. Malamud, Nathan P. Myhrvold, Satya Nadella, Daniel Reed, Harry Shum, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Publication number: 20200026170
    Abstract: An illumination system includes an input device configured to generate a first luminescent light beam; a pumping assembly, optically coupled to the input device, configured to project a pumping light beam into the input device; a focusing lens, aligned with the first luminescent light beam, to focus the first luminescent light beam enhanced by the pumping light beam as an output beam; and an output device, optically coupled to the focusing lens, configured to: receive the output beam from the focusing lens, and project an application output, formed with the output beam, from a projection device.
    Type: Application
    Filed: July 11, 2019
    Publication date: January 23, 2020
    Inventors: Yung Peng Chang, Alan Wang, Kirk Huang, Mark Chang, Lion Wang, Andy Chen, Kenneth Li
  • Publication number: 20200026169
    Abstract: An illumination system includes: a laser array assembly including: a laser configured to generate a laser light; a crystal phosphor waveguide, adjacent to the laser and in the laser light, configured to: generate of a luminescent light based on receiving the laser light, and direct the luminescent light away from a base end; and a compound parabolic concentrator (CPC), coupled to the crystal phosphor waveguide opposite the base end, configured to: collect the luminescent light from the crystal phosphor waveguide, project the luminescent light away from the crystal phosphor waveguide.
    Type: Application
    Filed: July 11, 2019
    Publication date: January 23, 2020
    Inventors: Yung Peng Chang, Alan Wang, Kirk Huang, Mark Chang, Lion Wang, Andy Chen, Kenneth Li
  • Patent number: 10539450
    Abstract: A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: January 21, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Barry Neil Fulkerson, Joe Fazio, Alec Huang, Brian Thomas Kelly, Tam Nolan, Mark Smith
  • Patent number: 10533052
    Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: January 14, 2020
    Assignee: Bristol-Myers Squibb Company
    Inventors: Xiao Min Schebye, Mark J. Selby, Michelle Minhua Han, Christine Bee, Andy X. Deng, Anan Chuntharapai, Brigitte Devaux, Huiming Li, Paul O. Sheppard, Alan J. Korman, Daniel F. Ardourel, Ekaterina Deyanova, Richard Huang, Guodong Chen, Michelle Kuhne, Hong-An Truong
  • Publication number: 20200002646
    Abstract: The disclosure relates to compositions comprising a polysaccharide derivative, wherein the polysaccharide derivative comprises a polysaccharide substituted with a) at least one hydrophobic group, and b) at least one hydrophilic group, wherein the polysaccharide is poly alpha-1,3-glucan, poly alpha-1,6-glucan, or poly alpha-1,3-1,6-glucan.
    Type: Application
    Filed: December 14, 2017
    Publication date: January 2, 2020
    Inventors: Zhengzheng Huang, Helen S M Lu, Weiming Qiu, Mukesh C. Shah, Steven W. Shuey, Mark Robert Sivik, Kristi Lynn Fliter
  • Patent number: 10523618
    Abstract: Methods, apparatuses, computer program products, devices and systems are described that carry out accepting at least one email communication from at least one member of a network; disambiguating the at least one search term including associating the at least one search term with at least one of network-participation identifier data or device-identifier data; and presenting the sender profile in association with the at least one email communication.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 31, 2019
    Assignee: Elwha LLC
    Inventors: Marc E. Davis, Matthew G. Dyor, William Gates, Xuedong Huang, Roderick A. Hyde, Edward K. Y. Jung, Jordin T. Kare, Royce A. Levien, Richard T. Lord, Robert W. Lord, Qi Lu, Mark A. Malamud, Nathan P. Myhrvold, Satya Nadella, Daniel Reed, Harry Shum, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Publication number: 20190390138
    Abstract: The disclosure relates to products including a polysaccharide derivative wherein the polysaccharide derivative includes a polysaccharide substituted with at least one of: a) at least one sulfate group; b) at least one sulfonate group; c) at least one thiosulfate group; or d) a combination thereof; wherein the polysaccharide is poly alpha-1,3-glucan, poly alpha-1,6-glucan, poly alpha-1,3-1,6-glucan, or a mixture thereof; and the polysaccharide derivative has a degree of substitution of about 0.001 to about 3. The products can be useful as anti-deposition and/or anti-graying agents in laundry detergents, and in home care applications.
    Type: Application
    Filed: June 19, 2019
    Publication date: December 26, 2019
    Inventors: Mark Robert SIVIK, Zhengzheng HUANG, Helen S.M. LU, Rakesh NAMBIAR, Jayme L. PAULLIN
  • Publication number: 20190378890
    Abstract: A rolled-up electromagnetic component for on-chip applications comprises: a multilayer sheet in a rolled configuration comprising at least one turn about a longitudinal axis; a core defined by a first turn of the rolled configuration; and a soft magnetic material disposed within the core, where the multilayer sheet comprises a conductive pattern layer on a strain-relieved layer. A method of making a rolled-up electromagnetic component for on-chip applications includes forming a rolled-up device comprising: a multilayer sheet in a rolled configuration having at least one turn about a longitudinal axis, where the multilayer sheet comprises a conductive pattern layer on a strain-relieved layer; and a core defined by a first turn of the rolled configuration. The method further includes introducing a soft magnetic material into the core.
    Type: Application
    Filed: June 7, 2019
    Publication date: December 12, 2019
    Inventors: Xiuling Li, Wen Huang, Zhendong Yang, Mark D. Kraman, Jimmy Ni, Zihao Ou, Qian Chen, J. Gary Eden
  • Publication number: 20190375770
    Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
    Type: Application
    Filed: December 5, 2018
    Publication date: December 12, 2019
    Applicant: AbbVie Inc.
    Inventors: Benoit Cardinal-David, Vincent S. Chan, Kassibla E. Dempah, Brian P. Enright, Rodger F. Henry, Raimundo Ho, Ye Huang, Alexander D. Huters, Russell C. Klix, Scott W. Krabbe, Philip R. Kym, Yanbin Lao, Xiaochun Lou, Sean E. Mackey, Mark A. Matulenko, Peter T. Mayer, Christiopher P. Miller, James Stambuli, Valentino J. Stella, Eric A. Voight, Zhi Wang, Geoff G. Zhang
  • Patent number: 10504525
    Abstract: A method of encoding audio information for forward error correction reconstruction of a transmitted audio stream over a lossy packet switched network, the method including the steps of: (a) dividing the audio stream into audio frames; (b) determining a series of corresponding audio frequency bands for the audio frames; (c) determining a series of power envelopes for the frequency bands; (d) encoding the envelopes as a low bit rate version of the audio frame in a redundant transmission frame.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: December 10, 2019
    Assignee: Dolby Laboratories Licensing Corporation
    Inventors: Xuejing Sun, Kai Li, Mark S. Vinton, Shen Huang
  • Patent number: 10501550
    Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: December 10, 2019
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
  • Publication number: 20190345569
    Abstract: The present invention relates to a method of selectively amplifying at least one nucleic acid sequence of at least one microorganism and/or virus in a sample of a subject, wherein k-mers 3 are applied that show a difference in frequency and/or context in the genome 2 of the at least one microorganism and/or virus compared to the genome of the subject 1.
    Type: Application
    Filed: November 28, 2017
    Publication date: November 14, 2019
    Inventors: Carsten Dietrich, Yiwei Huang, Mark Matzas, Andreas Emanuel Posch