Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

Abstract: Data replication with delta compression is disclosed. A primary system and a replica system are determined to both have an identical first data segment that is similar to a second data segment. The second data segment is encoded, wherein the encoding refers to the first data segment.

Abstract: Providing a subset of de-duplicated as output is disclosed. In some embodiments, the output comprises a subset of data stored in de-duplicated form in a plurality of containers each comprising a plurality of data segments comprising the data. For each container that includes one or more data segments comprising the subset, a corresponding container data is included in the output. Each container may include one or more segments not included in the subset. For each container the corresponding container data of which is included in the output, a corresponding value in a data structure comprising for each container stored on the de-duplicated storage system a data value indicating whether or not the corresponding container data has been included in the output is updated.

Abstract: Providing a subset of de-duplicated data as output is disclosed. The subset of data includes a plurality of data segments. In some embodiments, the output includes segments of data stored across a plurality of containers in a de-duplicated storage system. Each container stores one or more data segments from the subset as well as one or more segments not from the subset. For each container that includes at least one data segment from the subset, the corresponding container data is included in the output in its entirety, including segments that are not from the subset. In the event that container data is included in the output, a value in a data structure that corresponds to the container is updated. The data structure includes a value for each container in the de-duplicated storage system that indicates whether the corresponding container data has been included in the output.

Abstract: Delta compression after identity deduplication is disclosed. A first data segment is determined to be identical to a first previous data segment. A second data segment, not determined to be identical to a second previous data segment, is then determined to be similar to a third previous data segment.

Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

Abstract: Providing a subset of de-duplicated as output is disclosed. In some embodiments, the output comprises a subset of data stored in de-duplicated form in a plurality of containers each comprising a plurality of data segments comprising the data. For each container that includes one or more data segments comprising the subset, a corresponding container data is included in the output. Each container may include one or more segments not included in the subset. For each container the corresponding container data of which is included in the output, a corresponding value in a data structure comprising for each container stored on the de-duplicated storage system a data value indicating whether or not the corresponding container data has been included in the output is updated.

Abstract: Medical devices having bonded joints are disclosed. The bonded joints include two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces include materials that are suitable for medical devices. Most preferably, Nitinol includes at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device including a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin further includes a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device having contiguous heterogeneous structural elements of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.

Abstract: Stream locality delta compression is disclosed. A previous stream indicated locale of data segments is selected. A first data segment is then determined to be similar to a data segment in the stream indicated locale.

Abstract: A system for backup replication comprises a processor and a memory. The processor is configured to determine data present in a most recent backup not present in a previous backup; transmit an extent specification; and transmit data segment fingerprints of the one or more data segments. The memory is coupled to the processor and is configured to provide the processor with instructions.

Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

Abstract: Stream locality delta compression is disclosed. A previous stream indicated locale of data segments is selected. A first data segment is then determined to be similar to a data segment in the stream indicated locale.

Abstract: A subset of de-duplicated is outputted. In some embodiments, the output includes a subset of data stored in de-duplicated form in a plurality of containers each including a plurality of data segments comprising the data. For each container that includes one or more data segments comprising the subset, a corresponding container data is included in the output. Each container may include one or more segments not included in the subset. For each container the corresponding container data of which is included in the output, a corresponding value in a data structure including for each container stored on the de-duplicated storage system a data value indicating whether or not the corresponding container data has been included in the output is updated.

Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

Abstract: Transmitting filesystem changes over a network is disclosed. A hash of data comprising a chunk of directory elements comprising one or more consecutive directory elements in a set of elements sorted in a canonical order is computed at a client system. One or more directory elements comprising the chunk are sent to a remote server in the event it is determined based at least in part on the computed hash that corresponding directory elements as stored on the remote server are not identical to the directory elements comprising the chunk as stored on the client system.

Abstract: Medical devices comprised of bonded joints are disclosed. The bonded joints comprise two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces are comprised of materials that are suitable for medical devices. Most preferably, Nitinol comprises at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device comprised of a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin is further comprised of a radiopaque additive, a lubricious additive, or both radiopaque and lubricious additives. Also disclosed is an intraluminal device comprised of contiguous heterogeneous structural elements comprised of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.

Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support-structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.

Abstract: Medical devices having bonded joints are disclosed. The bonded joints include two surfaces bonded by a layer of phenoxy resin therebetween. In the preferred embodiments, bonded surfaces include materials that are suitable for medical devices. Most preferably, Nitinol includes at least one bonded surface, however, other preferred materials may include, but are not limited to cobalt chromium, stainless steel, titanium, tantalum, and plastic. An intraluminal device including a plurality of locations with a phenoxy resin layer is also disclosed wherein the phenoxy resin further includes a radioopaque additive, a lubricious additive, or both radioopaque and lubricious additives. Also disclosed is an intraluminal device having contiguous heterogeneous structural elements of metallic members and non-metallic sections that are bonded together by a layer of phenoxy resin therebetween.

Abstract: In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode, at least one guard electrode and at least one return electrode. The guard electrode is positioned between the wound and return electrodes in the electrical path of current traveling between the return and wound electrodes on the surface of the skin, sinking the surface current and force the wound current to travel deeper into the tissue. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate substantially surrounding the wound and guard electrodes and is designed to be placed over healthy tissue.