Patents by Inventor Mark Isalan

Mark Isalan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid binding proteins
    Patent number: 6977154
    Abstract: The invention provides a method for producing a zinc finger polypeptide which binds to a target nucleic acid sequence containing a modified base but not to an identical sequence containing an equivalent unmodified base.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: December 20, 2005
    Assignee: Gendaq Limited
    Inventors: Yen Choo, Mark Isalan
  • Nucleic acid binding proteins
    Patent number: 6866997
    Abstract: Disclosed herein are methods of designing zinc finger binding polypeptides for binding to particular target sequences comprising overlapping nucleotide quadruplets.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: March 15, 2005
    Assignee: Gendaq Limited
    Inventors: Yen Choo, Aaron Klug, Mark Isalan
  • Nucleic acid binding proteins
    Publication number: 20050037385
    Abstract: Disclosed herein are methods for designing DNA binding proteins comprising a plurality of zinc fingers and methods for binding the proteins to target nucleotide sequences in cells.
    Type: Application
    Filed: April 26, 2004
    Publication date: February 17, 2005
    Applicant: Gendaq Limited
    Inventors: Yen Choo, Aaron Klug, Mark Isalan
  • Nucleic acid binding proteins
    Publication number: 20040253623
    Abstract: Disclosed herein are methods for designing DNA binding proteins comprising a plurality of zinc fingers and methods for binding the proteins to target nucleotide sequences in cells.
    Type: Application
    Filed: May 24, 2004
    Publication date: December 16, 2004
    Applicant: Gendaq Limited
    Inventors: Yen Choo, Aaron Klug, Mark Isalan
  • Composition binding polypeptides
    Publication number: 20040197892
    Abstract: Disclosed herein are polypeptides with novel DNA binding specificities, constructed from combinations of zinc fingers, and methods for their preparation and use.
    Type: Application
    Filed: April 26, 2004
    Publication date: October 7, 2004
    Inventors: Michael Moore, Armin Sepp, Mark Isalan, Yen Choo
  • Nucleic acid binding polypeptides
    Publication number: 20040110923
    Abstract: We disclose a polypeptide capable of binding to a nucleic acid comprising a receptor nucleotide sequence.
    Type: Application
    Filed: February 5, 2004
    Publication date: June 10, 2004
    Inventors: Michael Moore, Mark Isalan, Lindsey Reynolds, Christopher Ullman, John Girdlestone, Christophe Demaison, Yen Choo
  • Nucleic acid binding proteins
    Patent number: 6746838
    Abstract: The invention provides a method for preparing a nucleic acid binding protein of the Cys2-His2 zinc finger class capable of binding to a nucleic acid quadruplet in a target nucleic acid sequence, wherein binding to base 4 of the quadruplet by an alpha-helical zinc finger nucleic acid binding motif in the protein is determined as follows: if base 4 in the quadruplet is A, then position +6 in the alpha-helix is Glu, Asn or Val; if base 4 in the quadruplet is C, then position +6 in the alpha-helix is Ser, Thr, Val, Ala, Glu or Asn.
    Type: Grant
    Filed: February 29, 2000
    Date of Patent: June 8, 2004
    Assignee: Gendaq Limited
    Inventors: Yen Choo, Aaron Klug, Mark Isalan
  • Modulation of viral gene expression by engineered zinc finger proteins
    Publication number: 20040039175
    Abstract: We disclose a polypeptide capable of binding to a nucleic acid comprising a viral nucleotide sequence. Preferably, the viral nucleotide sequence comprises a viral promoter sequence, for example, an HIV promoter or a herpesvirus promoter sequence.
    Type: Application
    Filed: November 7, 2002
    Publication date: February 26, 2004
    Inventors: Yen Choo, Christophe Demaison, Michael Moore, Monika Anna Papworth, Lindsey Reynolds, Christopher Graeme Ullman, Mark Isalan
  • Methods for modulating telomerase activity
    Publication number: 20030162200
    Abstract: The present invention relates to isolated or purified molecule(s) capable of binding to one or more of telomeric, G-quadruplex, or G-quartet nucleic acid(s).
    Type: Application
    Filed: October 15, 2002
    Publication date: August 28, 2003
    Applicant: Gendaq Limited and Cambridge University Technical Services, Ltd.
    Inventors: Yen Choo, Mark Isalan, Sachin D. Patel, Shankar Balasubramanian, Xiaohai Liu
  • Zinc finger polypeptides capable of binding DNA quadruplexes
    Patent number: 6492117
    Abstract: The present invention relates to isolated or purified molecule(s) capable of binding to one or more of telomeric, G-quadruplex, or G-quartet nucleic acid(s).
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: December 10, 2002
    Assignee: Gendaq Limited
    Inventors: Yen Choo, Mark Isalan, Sachin D. Patel, Shhankar Balasubramanian, Xiaohai Liu