Patents by Inventor Mark J. Lim

Mark J. Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190227055
    Abstract: The invention relates to compositions and methods for the concentration and/or purification of analytes, such as biomarkers, typically from complex biological samples such as whole blood, serum or plasma. This invention also relates to the use of binding agents, such as antibodies, aptamers, antigens and engineered protein scaffold based binding agents (e.g. commercially available Affibodies®), to facilitate the concentration and/or purification of said analytes. This invention further relates to assays used to detect, measure and/or quantify the analyte after its concentration and/or purification, preferably solid-phase immunoassays and more preferably multiplex solid-phase immunoassays.
    Type: Application
    Filed: January 18, 2019
    Publication date: July 25, 2019
    Inventors: Mark J. Lim, Heather P. Ostendorff, Zhi Wan, John Gillespie, Kenneth J. Rothschild
  • Patent number: 10323677
    Abstract: Systems, methods, and devices for securing structures include a fastener that includes a threaded body and a head. The head includes a rounded axial protrusion having a first radial diameter, and a noncircular radial portion for securing the fastener. The noncircular radial portion has a second radial diameter greater than the first radial diameter. The noncircular radial portion is positioned between the threaded body and the rounded axial protrusion.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: June 18, 2019
    Assignee: Motorola Mobility LLC
    Inventors: David K Lim, Paul Fordham, Mark Daniel Jannick, Eric J. Kutchery, Pavana Abhiram Sirimamilla
  • Publication number: 20190004038
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 3, 2019
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Patent number: 10088474
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 2, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J Lim, Kenneth J Rothschild
  • Patent number: 10060912
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: August 28, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J Lim, Vladislav B Bergo, Kenneth J Rothschild
  • Patent number: 9910034
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: March 6, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20180017550
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 18, 2018
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20170307607
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Application
    Filed: March 24, 2017
    Publication date: October 26, 2017
    Inventors: Mark J. LIM, Heather P. OSTENDORFF, Kenneth J. ROTHSCHILD, Donald B. BLOCH
  • Publication number: 20170089891
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 30, 2017
    Inventors: Mark J Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Patent number: 9523680
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 20, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Patent number: 9513285
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: December 6, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Publication number: 20160139113
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: October 6, 2015
    Publication date: May 19, 2016
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Patent number: 9334530
    Abstract: Methods of amplifying nucleic acid on a solid support are described. Beads and template, each in known concentrations, are employed so a range of template to bead ratios can be exploited. Where the beads contain primers, the template can be amplified. After amplification, non-covalently bound template is removed, so as to leave beads with extended primers (or beads with primers that were not extended).
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: May 10, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20160018396
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 21, 2016
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20150192577
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: January 14, 2015
    Publication date: July 9, 2015
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20150141297
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: October 21, 2014
    Publication date: May 21, 2015
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Publication number: 20150057170
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Application
    Filed: June 27, 2014
    Publication date: February 26, 2015
    Inventors: Mark J. LIM, Heather P. OSTENDORFF, Kenneth J. ROTHSCHILD, Donald B. BLOCH
  • Patent number: 8932879
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 13, 2015
    Assignee: Ambergen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Patent number: 8906700
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: December 9, 2014
    Assignee: Ambergen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Patent number: 8852956
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: October 7, 2014
    Assignees: Ambergen, Inc., Massachusetts General Hospital
    Inventors: Mark J. Lim, Heather P. Ostendorf, Kenneth J. Rothschild, Donald B. Bloch