Patents by Inventor Mark J. Lim

Mark J. Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Global Proteomic Screening of Random Bead Arrays Using Mass Spectrometry Imaging
    Publication number: 20190004038
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: July 10, 2018
    Publication date: January 3, 2019
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Methods and compositions for phototransfer
    Patent number: 10088474
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: October 2, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J Lim, Kenneth J Rothschild
  • Global proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 10060912
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: August 28, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J Lim, Vladislav B Bergo, Kenneth J Rothschild
  • Methods and compositions for phototransfer
    Patent number: 9910034
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: March 6, 2018
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • METHODS AND COMPOSITIONS FOR PHOTOTRANSFER
    Publication number: 20180017550
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 18, 2018
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • A METHOD FOR DIAGNOSING PRIMARY BILIARY CIRRHOSIS (PBC) USING NOVEL AUTOANTIGENS
    Publication number: 20170307607
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Application
    Filed: March 24, 2017
    Publication date: October 26, 2017
    Inventors: Mark J. LIM, Heather P. OSTENDORFF, Kenneth J. ROTHSCHILD, Donald B. BLOCH
  • GLOBAL PROTEOMIC SCREENING OF RANDOM BEAD ARRAYS USING MASS SPECTROMETRY IMAGING
    Publication number: 20170089891
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 30, 2017
    Inventors: Mark J Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Global Proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 9523680
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: December 20, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Global proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 9513285
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: December 6, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Methods and Compositions for Phototransfer
    Publication number: 20160139113
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: October 6, 2015
    Publication date: May 19, 2016
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Methods for making and imaging arrays that comprise a plurality of different biomolecules
    Patent number: 9334530
    Abstract: Methods of amplifying nucleic acid on a solid support are described. Beads and template, each in known concentrations, are employed so a range of template to bead ratios can be exploited. Where the beads contain primers, the template can be amplified. After amplification, non-covalently bound template is removed, so as to leave beads with extended primers (or beads with primers that were not extended).
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: May 10, 2016
    Assignee: AmberGen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Methods and Compositions for Phototransfer
    Publication number: 20160018396
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 21, 2016
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Methods and Compositions for Phototransfer
    Publication number: 20150192577
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: January 14, 2015
    Publication date: July 9, 2015
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Methods and Compositions for Phototransfer
    Publication number: 20150141297
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Application
    Filed: October 21, 2014
    Publication date: May 21, 2015
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • METHOD FOR DIAGNOSING PRIMARY BILIARY CIRRHOSIS (PBC) USING NOVEL AUTOANTIGENS
    Publication number: 20150057170
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Application
    Filed: June 27, 2014
    Publication date: February 26, 2015
    Inventors: Mark J. LIM, Heather P. OSTENDORFF, Kenneth J. ROTHSCHILD, Donald B. BLOCH
  • Methods and compounds for phototransfer
    Patent number: 8932879
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: January 13, 2015
    Assignee: Ambergen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Methods and compositions for phototransfer
    Patent number: 8906700
    Abstract: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure to electromagnetic radiation. Illuminating the compound with radiation photocleaves the compound from the first surface and transfers the compound to the second surface.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: December 9, 2014
    Assignee: Ambergen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild
  • Method for diagnosing primary biliary cirrhosis (PBC) using novel autoantigens
    Patent number: 8852956
    Abstract: Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: October 7, 2014
    Assignees: Ambergen, Inc., Massachusetts General Hospital
    Inventors: Mark J. Lim, Heather P. Ostendorf, Kenneth J. Rothschild, Donald B. Bloch
  • Global Proteomic Screening Of Random Bead Arrays Using Mass Spectrometry Imaging
    Publication number: 20140235471
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: December 17, 2013
    Publication date: August 21, 2014
    Applicant: Ambergen, Inc.
    Inventors: Vladislav B. Bergo, Mark J. Lim, Kenneth J. Rothschild
  • Amplifying bisulfite-treated template
    Patent number: 8486634
    Abstract: Methods of amplifying nucleic acid are described. Primers on solid support, e.g. a population of beads, are employed. A population of nucleic acid template molecules, wherein the nucleic acid template molecules have been treated with bisulfite, is amplified so as to create loaded beads comprising amplified nucleic acid.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: July 16, 2013
    Assignee: Ambergen, Inc.
    Inventors: Mark J. Lim, Kenneth J. Rothschild