Abstract: A space-saving configuration for electronics is disclosed in which at least four circuit boards are arranged to form sides of a five-or-greater sided geometric prism that are perpendicular to a common plane. That is, they are stood up on their sides and connected with flex cable to approximate a cylinder. Each circuit board can include one or more sides with electrical components. The circuit boards make up at least half of the five-or-greater sided geometric prism such that the circuit boards wrap at least halfway around. A common connector on one of the circuit boards can be configured to receive power from an underlying motherboard, and flex cables connecting adjacent circuit boards in series distribute power received from the connector to each of the circuit boards in series.

Abstract: A disposable cartridge for use in a diagnostic assay system including a cartridge body defining a barrel port. A rotor is rotationally mounted to the cartridge body and comprises a plurality of assay chambers and a plurality of rotor ports each fluidly coupled to at least one of the plurality of assay chambers. A syringe is coupled to the cartridge body and operative to inject and withdraw assay fluids through the barrel port. The syringe includes a barrel defining an internal environment, a plunger positioned in the barrel and structured to move within a working area, and a disposable shaft structured to detachably mate at a first end with the plunger. The disposable shaft is isolated from the internal environment of the barrel.

Abstract: A space-saving configuration for electronics is disclosed in which at least four circuit boards are arranged to form sides of a five-or-greater sided geometric prism that are perpendicular to a common plane. That is, they are stood up on their sides and connected with flex cable to approximate a cylinder. Each circuit board can include one or more sides with electrical components. The circuit boards make up at least half of the five-or-greater sided geometric prism such that the circuit boards wrap at least halfway around. A common connector on one of the circuit boards can be configured to receive power from an underlying motherboard, and flex cables connecting adjacent circuit boards in series distribute power received from the connector to each of the circuit boards in series.

Abstract: A disposable cartridge for mitigating cross-contamination of fluid sample reagents. The disposable cartridge includes a cartridge body defining a syringe barrel having an barrel port operative to inject and withdraw assay fluids in response to the displacement of a syringe plunger. Furthermore, the disposable cartridge includes a rotor defining a plurality of assay chambers in fluid communication with the barrel port through one of a plurality of rotor ports disposed about the periphery of the rotor. Finally, the disposable cartridge includes a flow control system between the barrel and rotor ports which prevents cross-contamination of fluid sample reagents from one assay chamber to another assay chamber.

Abstract: A method for inserting and retaining a reagent within a disposable cartridge of a diagnostic assay system. The method includes the steps of: (i) drying a reagent in combination with a carrier, and (ii) inserting the carrier, with the dried reagent, into an open end of one of the assay chambers, wherein the carrier facilitates insertion of the pellet into a chamber without contact by an operator.

Abstract: A method for inserting and retaining a reagent within a disposable cartridge of a diagnostic assay system. The method includes the steps of: (i) drying a reagent in combination with a carrier, and (ii) inserting the carrier, with the dried reagent, into an open end of one of the assay chambers, wherein the carrier facilitates insertion of the pellet into a chamber without contact by an operator.

Abstract: A disposable cartridge for mitigating cross-contamination of fluid sample reagents. The disposable cartridge includes a cartridge body defining a syringe barrel having an barrel port operative to inject and withdraw assay fluids in response to the displacement of a syringe plunger. Furthermore, the disposable cartridge includes a rotor defining a plurality of assay chambers in fluid communication with the barrel port through one of a plurality of rotor ports disposed about the periphery of the rotor. Finally, the disposable cartridge includes a flow control system between the barrel and rotor ports which prevents cross-contamination of fluid sample reagents from one assay chamber to another assay chamber.

Abstract: Footwear includes structural features that may provide one or more of the following features or functions: (a) help “lock” the wearer to the ground under torsional forces induced in the leg/foot (e.g., by a golf swing or other activities); (b) help provide stable support, e.g., at the medial heel and/or lateral forefoot areas; (c) help support and prevent undesired distortion of the footwear upper, e.g., when torsional forces are applied; and/or (d) help provide a very stable and secure feel and fit by securing across the instep portion of the foot, e.g., in a forward lateral-to-rear medial direction (e.g., between medial heel and lateral forefoot sidewall supports).

Abstract: A disposable cartridge for mitigating cross-contamination of fluid sample reagents. The disposable cartridge includes a cartridge body defining a syringe barrel having an barrel port operative to inject and withdraw assay fluids in response to the displacement of a syringe plunger. Furthermore, the disposable cartridge includes a rotor defining a plurality of assay chambers in fluid communication with the barrel port through one of a plurality of rotor ports disposed about the periphery of the rotor. Finally, the disposable cartridge includes a flow control system between the barrel and rotor ports which prevents cross-contamination of fluid sample reagents from one assay chamber to another assay chamber.

Abstract: A method for optimizing the heat transfer when performing target amplification of an assay fluid, comprising the steps of: (i) moving assay fluid through at least one channel disposed along an underside surface of a disposable cartridge of a diagnostic assay test device such that the fluid collects in a amplification region of the channel; (ii) heating the amplification region of the assay channel to heat the assay fluid; (iii) interposing a conformal material between the underside surface of a disposable cartridge and the RF heater, and (iv) applying a contact pressure between the underside surface of a disposable cartridge and the RF heater.

Abstract: An article of footwear includes an upper having a toe box and a forefoot portion adjacent the toe box. The forefoot portion has a first region having a first stiffness. The article of footwear also includes a transition region including an elastomeric transition layer disposed on and partially covering the first region. The transition region has a second stiffness that is greater than the first stiffness. The article of footwear further includes a toe cap disposed on and partially covering the elastomeric transition layer at the toe box.

Abstract: A method for inserting and retaining a reagent within a disposable cartridge of a diagnostic assay system. The method includes the steps of: (i) drying a reagent in combination with a carrier, and (ii) inserting the carrier, with the dried reagent, into an open end of one of the assay chambers, wherein the carrier facilitates insertion of the pellet into a chamber without contact by an operator.

Abstract: A software method to effectuate value enhancement riders that attach to indexed universal life insurance policies. The system enables the policy to substantially expand the policies notional values exposed to market volatility. The enhancement rider(s) come in three forms: a premium based enhancement rider, an accumulated value based enhancement rider and a combination of the two riders. Policy owners can opt in and opt out of the rider(s) annually. The software system nests insider a carrier's home office policy administration system and performs all the operational and maintenance functions that the rider(s) requires to function properly. Importantly these rider(s) dramatically affect the operating parameters of the policy. These rider(s) change the mundane accumulation performance associated with that of typical indexed life insurance policy into the financial industry's leading source of cash accumulation.

Abstract: A disposable cartridge for mitigating cross-contamination of fluid sample reagents. The disposable cartridge includes a cartridge body defining a syringe barrel having an barrel port operative to inject and withdraw assay fluids in response to the displacement of a syringe plunger. Furthermore, the disposable cartridge includes a rotor defining a plurality of assay chambers in fluid communication with the barrel port through one of a plurality of rotor ports disposed about the periphery of the rotor. Finally, the disposable cartridge includes a flow control system between the barrel and rotor ports which prevents cross-contamination of fluid sample reagents from one assay chamber to another assay chamber.

Abstract: Footwear includes structural features that may provide one or more of the following features or functions: (a) help “lock” the wearer to the ground under torsional forces induced in the leg/foot (e.g., by a golf swing or other activities); (b) help provide stable support, e.g., at the medial heel and/or lateral forefoot areas; (c) help support and prevent undesired distortion of the footwear upper, e.g., when torsional forces are applied; and/or (d) help provide a very stable and secure feel and fit by securing across the instep portion of the foot, e.g., in a forward lateral-to-rear medial direction (e.g., between medial heel and lateral forefoot sidewall supports).

Abstract: A diagnostic assay system includes a platform configured to receive a disposable cartridge having a sample chamber for receipt of an assay fluid, and an a PCR chamber disposed in fluid communication with the sample chamber for performing target amplification of the assay fluid. A heating source is disposed adjacent a heat exchange surface disposed along at least one side of the PCR chamber and is configured to conform to the contour of the heat exchange surface to accelerate target amplification of the assay fluid. The heating source introduces heat into the assay fluid from one side of the disposable cartridge and, in one embodiment, employs a conformal material interposing the heating source and the heat exchange surface to mitigate the formation of air pockets therebetween.

Abstract: An article of footwear includes an upper assembly with an upper and an upper covering member. The upper covering member includes a lighting panel layer capable of illuminating the upper covering member. A majority of the upper covering member may be configured to illuminate.

Abstract: Articles of footwear or other foot-receiving devices include an upper/foot-covering member having medial and lateral strap tensioning components located on opposite sides of the ankle area. A securing system is provided that includes: (i) a first strap portion extending across the instep area, engaging the lateral strap tensioning component, and extending in front of the foot-insertion opening to the medial ankle side (where it may be secured), and (ii) a second strap portion extending across the instep area, engaging the medial strap tensioning component, and extending in front of the foot-insertion opening and to the lateral ankle side (where it may be secured). The first and second strap portions cross one another at two separated crossing locations.