Patents by Inventor Mark James O'Connor

Mark James O'Connor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING CANCER
    Publication number: 20220387468
    Abstract: Methods of treating cancer with a combination of a WEE1 inhibitor and a DNA-damaging agent in patients having SLFN11-deficient cancer cells are disclosed herein.
    Type: Application
    Filed: October 23, 2020
    Publication date: December 8, 2022
    Inventors: Elisabetta LEO, Claudia WINKLER, Mark James O'CONNOR, Gemma Nicole JONES, Andrew James PIERCE
  • COMBINATION OF CHK AND PARP INHIBITORS FOR THE TREATMENT OF CANCERS
    Publication number: 20100249112
    Abstract: A combination, comprising a checkpoint kinase (CHK) inhibitor, or a pharmaceutically acceptable salt thereof, and a poly (ADP-ribose)polymerase (PARP) inhibitor, or a pharmaceutically acceptable salt thereof is described.
    Type: Application
    Filed: May 23, 2008
    Publication date: September 30, 2010
    Applicant: ASTRAZENECA R&D
    Inventors: Mark James O'Connor, Graeme Cameron Murray Smith, Sonya Zabludoff
  • ATM inhibitors
    Patent number: 7049313
    Abstract: The application concerns a compound of formula I: wherein one of P and Q is O, and the other of P and Q is CH, where there is a double bond between whichever of Q and P is CH and the carbon atom bearing the R3 group; Y is either O or S; R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; R3 is a phenyl or pyridyl group, attached by a first bridge group selected from —S—, —S(?O)—, —S(?O)2—, —O—, —NRN— and CRC1RC2— to an optionally substituted C5-20 carboaryl group, the phenyl or pyridyl group and optionally substituted C5-20 carboaryl group being optionally further linked by a second bridge group, so as to form an optionally substituted C5-7 ring, the phenyl or pyridyl group being further optionally substituted.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: May 23, 2006
    Assignee: Kudos Pharmaceuticals Ltd.
    Inventors: Graeme Cameron Murray Smith, Niall Morrison Barr Martin, Stephen Philip Jackson, Mark James O'Connor, Alan Yin Kai Lau, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Laurent Jean Martin Rigoreau, Marc Geoffery Hummersone, Roger John Griffin
  • Methods and means for improving retroviral integration
    Publication number: 20040197913
    Abstract: Retroviral integration is promoted in mammalian cells by inhibition of RAD52 DNA-binding activity, e.g. using RNAi. This is useful in gene therapy, especially ex vivo. Retroviral integration is inhibited by increasing mammalian RAD52 DNA-binding activity, useful in inhibiting retroviruses.
    Type: Application
    Filed: September 8, 2003
    Publication date: October 7, 2004
    Inventors: Mark James O'Connor, Stephen Philip Jackson, Alan Lau
  • Inhibiting retrotransposon and retroviral integration by targeting the atm pathway
    Publication number: 20040014701
    Abstract: Ataxia telangiectasia mutated (ATM)-dependent DNA damage signalling mechanisms are involved in retroviral and retrotransposon integration. Screening methods for inhibitors of retroviral and retrotranspons activity comprise inhibiting the ATM-dependent DNA damage signalling pathway, e.g. by disrupting interaction between components of the pathway. Inhibitors are useful as anti-retroviral agents, e.g. in inhibition of HIV.
    Type: Application
    Filed: July 18, 2003
    Publication date: January 22, 2004
    Inventors: Mark James O'Connor, Stephen Philip Jackson, Alan Lau
  • ATM inhibitors
    Publication number: 20040002492
    Abstract: The application concerns a compound of formula I: 1
    Type: Application
    Filed: February 24, 2003
    Publication date: January 1, 2004
    Applicant: Kudos Pharmaceuticals Ltd
    Inventors: Graeme Cameron Murray Smith, Niall Morrison Barr Martin, Stephen Philip Jackson, Mark James O'Connor, Alan Yin Kai Lau, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Laurent Jean Martin Rigoreau, Marc Geoffery Hummersone, Roger John Griffin