Abstract: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: This disclosure provides a method for generating an optimal tree for rendering or streaming a 3D model. The method includes: obtaining a complete tree of a 3D model; obtaining a quality value of a node of the complete tree of the 3D model; obtaining a visibility value of the node of the complete tree of the 3D model; determining an optimal tree of the 3D model based on the complete tree, the quality value, and the visibility value; and rendering the 3D model based on the optimal tree.

Abstract: A method, computer program product, and computer system are provided for user access group discovery. The method includes: generating a matrix that depicts the respective resources of a set of resources accessed by each of a plurality of users; obtaining, for each user, a similarity measurement using the matrix, wherein the similarity measurement is based on a comparison of the resources accessed by the user to the resources accessed by the other users; generating, for each user, a feature vector for clustering the users into user access groups, wherein the feature vector represents the resources accessed by the user; applying the feature vectors and the similarity measurements to a centroid-based clustering algorithm to obtain the user access groups; and outputting the user access groups for application in a security environment.

Abstract: Provided herein are methods and systems for identifying a related data values in a plurality of datasets. The method can include extracting data from the plurality of datasets, identifying potential linking categories, and determining a validity of the potential linking categories. One or more linking categories can be selected from the potential linking categories based on the validity, and related data values can be identified between the plurality of datasets based on the selected linking categories. Also provided herein are methods and systems for classifying data values as reconciled or non-reconciled. The method can include identifying a plurality of related data values in a plurality of datasets. For each of the plurality of related data values, a similarity score and confidence score can be determined, and the plurality of related data values can be classified as reconciled or non-reconciled based on the similarity score and/or the confidence score.

Abstract: Described herein is a method of training a model configured to predict whether a feature associated with an imaged substrate will be defective after etching of the imaged substrate and determining etch conditions based on the trained model. The method includes obtaining, via a metrology tool, (i) an after development image of the imaged substrate at a given location, the after development image including a plurality of features, and (ii) an after etch image of the imaged substrate at the given location; and training, using the after development image and the after etch image, the model configured to determine defectiveness of a given feature of the plurality of features in the after development image. In an embodiment, the determining of defectiveness is based on comparing the given feature in the after development image with a corresponding etch feature in the after etch image.

Abstract: Systems and methods for automated document processing for use in AI-augmented auditing platforms are provided. A system for determining the composition of document bundles extracts substantive content information and metadata information from a document bundle and generates, based on the extracted information regarding a composition of the document bundle. A system for validating signatures in documents extracts data representing a spatial location for respective signatures and generates a confidence level for respective signatures, and determines, based on location and confidence level, whether signature criteria are met. A system for extracting information from documents applies a set of data conversion processing steps to a plurality received documents to generate structured data, and then applies a set of knowledge-based modeling processing steps to the structured data to generating output data extracted from the plurality of electronic documents.

Abstract: A light-emitting system is provided which is removably attachable to headgear for personal illumination to enhance visibility of the user to others. The light-emitting system includes a housing that defines a receiving aperture and is configured to surround a portion of the headgear when the light-emitting system is removably attached to the headgear for use. The light-emitting system further includes at least one lens and a plurality of lighting elements coupled to the annular housing which are configured to selectively generate a halo or at least a partial halo of light that radiates outwardly away from the annular housing through the at least one lens to provide enhanced personal illumination.

Abstract: This invention relates to a wholly recombinant four factor hemostatic complex concentrate (4F-PCC) composition, human liver cell-produced product. Methods of producing a hemostatic composition using a hepatocyte cell line and a CRISPR/Cas9 gene activation multiplexing, which allows for simultaneous and high level expression of the FII, FVII, FIX, and FX clotting factors. The resultant product is a recombinant resuscitation solution to aid in mitigation of coagulopathy, reversal of coagulopathic states, and fluid resuscitation.

Abstract: The present invention relates to a method for increasing the activity and/or the yield of a recombinant vitamin K-dependent protein expressed in cell culture. The present invention further relates to uses and compositions of matter.

Abstract: Provided herein are methods and systems for identifying a related data values in a plurality of datasets. The method can include extracting data from the plurality of datasets, identifying potential linking categories, and determining a validity of the potential linking categories. One or more linking categories can be selected from the potential linking categories based on the validity, and related data values can be identified between the plurality of datasets based on the selected linking categories. Also provided herein are methods and systems for classifying data values as reconciled or non-reconciled. The method can include identifying a plurality of related data values in a plurality of datasets. For each of the plurality of related data values, a similarity score and confidence score can be determined, and the plurality of related data values can be classified as reconciled or non-reconciled based on the similarity score and/or the confidence score.

Abstract: Disclosed is a one-piece, integrally formed universal backing ring having an integrally formed, one piece annular structure with a center opening configured to be translated over a journal of a railcar axle and engage a dust guard and a dust guard fillet of the railcar axle. The annular structure includes an inner contoured surface having a profile that is contoured for a tight surface fit with a complementary surface of the dust guard fillet. The annular structure also includes a dust guard lip which projects over the dust guard fillet and engages the dust guard. The dust guard lip has a length extending generally parallel with an axis of the annular structure, and is configured to provide a mechanical interference fit of the dust guard lip with the dust guard of 0.052-0.1875 inches with a maximum diameter of the dust guard for each Class of railcar axle.

Abstract: A system for use in servicing a machine. The system includes a tubular body including a longitudinal axis, a tip end, a dispensing nozzle defined at the tip end, and an interior channel in flow communication with the dispensing nozzle. The tubular body is configured to be flexible. An actuator is configured to selectively modify an orientation of the tubular body, and a reservoir is in flow communication with the interior channel. The reservoir is configured to supply a maintenance fluid to the tubular body for discharge from the dispensing nozzle.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using lysenin.

Abstract: The invention relates to modified helicases with reduced unbinding from polynucleotides. The helicases can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

Abstract: A no-back brake system for an actuator includes a ball ramp mechanism. A drag brake assembly is configured to be coupled to a first portion of the ball ramp mechanism. A main brake assembly is configured to be coupled to an actuator and a second portion of the ball ramp mechanism. A limited authority damper assembly is disposed between the drag brake assembly and the main brake assembly. The limited authority damper assembly includes an outer spacing ring configured to be coupled to the drive shaft of the actuator, an inner damping ring coupled to the outer spacing ring and the drag brake assembly, and a first spring disposed between the outer spacing ring and the inner damping ring.

Abstract: An installation apparatus for connecting a fluid fitting to a fluid element includes a tool mechanism having a first abutment surface and a second abutment surface that faces and is movable relative to the first abutment surface; a first sensor configured to detect a first property of the installation apparatus or fluid fitting and provide a first output corresponding to the first property; a second sensor configured to detect a second property of the installation apparatus or fluid fitting and provide a second output corresponding to the second property; and a processing unit that is configured to generate a first resulting data set based on the first output and second output, and compare the resulting data set with a first predetermined data set to determine if the first resulting data set is compliant with the first predetermined data set.

Abstract: A pharmaceutical product for administration of an anti TROP2 antibody-drug conjugate in combination with an ATR inhibitor is provided. The anti-TROP2 antibody-drug conjugate is an antibody-drug conjugate in which a drug linker represented by the following formula (wherein A represents the connecting position to an anti-TROP2 antibody) is conjugated to an anti-TROP2 antibody via a thioether bond. Also provided is a therapeutic use and method wherein the anti-TROP2 antibody-drug conjugate and the ATR inhibitor are administered in combination to a subject: Formula (I).

Abstract: A biopharmaceutical flow port, a biopharmaceutical liquid container assembly, and a method for manufacturing the biopharmaceutical flow port and the biopharmaceutical liquid container assembly are described. The biopharmaceutical flow port includes a hose barb coupled to an elliptic body. The hose barb includes a bore. The elliptic body includes a flow passage, a first edge, and a second edge. The flow passage is fluidly coupled to the bore. The first edge extends from the elliptic body away from the flow passage in a first direction and the second edge extends from the elliptic body away from the flow passage in a second direction opposite the first direction. The biopharmaceutical liquid container assembly includes a biopharmaceutical liquid container with an opening and the biopharmaceutical flow port coupled to the biopharmaceutical liquid container within the opening and in fluid communication with a volume of the biopharmaceutical liquid container.

Abstract: Systems and methods for automated document processing for use in AI-augmented auditing platforms are provided. A system for determining the composition of document bundles extracts substantive content information and metadata information from a document bundle and generates, based on the extracted information regarding a composition of the document bundle. A system for validating signatures in documents extracts data representing a spatial location for respective signatures and generates a confidence level for respective signatures, and determines, based on location and confidence level, whether signature criteria are met. A system for extracting information from documents applies a set of data conversion processing steps to a plurality received documents to generate structured data, and then applies a set of knowledge-based modeling processing steps to the structured data to generating output data extracted from the plurality of electronic documents.