Abstract: A process for the preparation of 1,3-bis(allylamino)propane is provided. According to one aspect, the process for the preparation of 1,3-bis(allylamino)propane includes i) forming a reaction mixture containing allylamine (CH2?CH2CH2NH2) and a difunctional propane, (ii) separating a 1,3-bis(allylamino)propane product from the reaction mixture, and (iii) recovering any excess, unreacted allylamine from the reaction mixture.

Abstract: The present disclosure encompasses methods of cancer immunotherapy, and particularly methods of allogeneic cellular immunotherapy, using particular lymphodepletion regimens in combination with particular populations of chimeric antigen receptor T cells.

Abstract: An aircraft has a landing gear that can be extended and retracted and a landing gear control system that is configured so that it can cause extension/retraction of the landing gear of the aircraft in response to pilot operation of a landing gear lever. The control system is also configured such that in the scenario of pilot incapacitation, it can cause extension/retraction of the landing gear of the aircraft in response to an automated command for landing gear extension/retraction. A kit of parts including a relaying unit can be used for converting an existing aircraft to one that has this functionality. There is also a method of automatically extending/retracting landing gear, for example in the event of pilot incapacitation when performing single-pilot operation of the aircraft.

Abstract: An inner middle rotor is rotated while an inner front rotor, an inner back rotor, and an outer rotor are not rotated. The inner middle rotor is surrounded by the inner front rotor, the inner back rotor, the outer rotor, and a fuselage. After rotating the inner middle rotor while not rotating the inner front rotor, the inner back rotor, and the outer rotor, the inner middle rotor, the inner front rotor, the inner back rotor, and the outer rotor are simultaneously rotated.

Abstract: A data corpus is partitioned into text strings for header classification. A group characteristic is computed for a text string, and whether the group characteristic satisfies a group characteristic criterion is determined. The text string may be disqualified from header classification if the group characteristic criterion is not satisfied, or one or more font characteristics may be determined for the text string if the group characteristic criterion is satisfied. A font characteristic that meets one or more prevalence criteria may be identified and evaluated to determine whether the font characteristic meets at least one font characteristic criterion. The text string may be disqualified from header classification if the font characteristic criterion is not satisfied, or if the font characteristic meets the font characteristic criterion, the text string is classified as a header, and tagged content is generated by applying a header tag to the text string.

Abstract: Bird's eye view (BEV) semantic mapping systems and methods are provided. A method includes receiving an image captured by a monocular camera having a first point of view (POV) of an environment including a plurality of features. The method further includes processing, by an artificial neural network (ANN), the captured image to generate a semantic map for the captured image, the semantic map associated with a second POV different from the first POV. The features exhibit a uniform scale in the semantic map. Additional methods and associated systems are also provided.

Abstract: Techniques are disclosed for systems and methods to provide passage planning for a mobile structure. A passage planning system includes a logic device configured to communicate with a user interface associated with the mobile structure and at least one operational state sensor mounted to or within the mobile structure. The logic device determines an operational range map based, at least in part, on an operational state of the mobile structure, potential navigational hazards, and/or environmental conditions associated with the mobile structure. Such operational range map and other control signals may be displayed to a user and/or used to generate a planned route and/or adjust a steering actuator, a propulsion system thrust, and/or other operational systems of the mobile structure.

Abstract: A method performed by a surgical robotic system. The method determines a surgical procedure that is to be performed using a robotic arm. The method determines, for the robotic arm, a planned trajectory based on the surgical procedure, where the planned trajectory is from a current pose of the robotic arm to a predefined procedure pose that is within a threshold distance from a trocar that is coupled to a patient. The method drives the robotic arm along the planned trajectory from the current pose to the predefined procedure pose.

Abstract: Sensor data is received from an inertial measurement unit on a vehicle. An observed attitude and an observed attitude rate of the vehicle are determined based on the sensor data. Using a model associated with a vehicle failure mode, an expected attitude and an expected attitude rate of the vehicle are determined. A malfunctioning rotor is determined based on the observed attitude, the observed attitude rate, the expected attitude, and the expected attitude rate. In response to identifying the malfunctioning rotor, a responsive action is performed, including by updating a geometry matrix so that at least one non-malfunctioning rotor in the plurality of rotors compensates for the malfunctioning rotor.

Abstract: Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

Abstract: An electrochemical device includes an electrolyte having a hydroxamate or N-hydroxyamide compound.

Abstract: A method for engaging and disengaging a surgical instrument of a surgical robotic system including receiving a sequence of user inputs from one or more user interface devices of the surgical robotic system; determining, by one or more processors communicatively coupled to the user interface devices and the surgical instrument, whether the sequence of user inputs indicates an intentional engagement or disengagement of a teleoperation mode in which the surgical instrument is controlled by user inputs received from the user interface devices; in response to determining of engagement, transition the surgical robotic system into the teleoperation mode; and in response to determining of disengagement, transition the surgical robotic system out of the teleoperation mode such that the user interface devices are prevented from controlling the surgical instrument.

Abstract: Compositions, and methods and uses thereof are provided, wherein the compositions comprise a biologically active agent and one or more solvents that dissolve the biologically active agent.

Abstract: Techniques for multi-layer training of a machine learning model are disclosed. A system pre-trains a machine learning model on training data obtained from unlabeled document graph data by executing unsupervised pre-training tasks on the unlabeled document graph data to generate a labeled pre-training data set. The system modifies document graphs to change attributes of nodes in the document graphs. The system pre-trains the machine learning model with a data set including the modified document graphs and un-modified document graphs to generate prediction associated with the modifications to the document graphs. Subsequent to pre-training, the system fine-tunes the machine learning model with a set of labeled training data to generate predictions associated with a specific attribute of a document graph.

Abstract: A vertical takeoff and landing vehicle which includes an allocation block that receives a set of desired forces or desired moments and a health metric associated with at least one of: (1) a motor controller or (2) a rotor that operates in a vertical takeoff and landing mode at least some of the time. A command signal is determined per a first manner that attempts to satisfy both the set of desired forces or desired moments and the health metric. If the command signal is unable to be determined in the first manner, a second manner is used that prioritizes flight control associated with one or more of a roll axis or a pitch axis over flight control associated with a yaw axis where the axes are mutually orthogonal. The command signal is output to the motor controller that controls the rotor using the command signal.

Abstract: Techniques are disclosed for systems and methods to provide docking assist for mobile structures. A docking assist system includes a logic device, one or more sensors, one or more actuators/controllers, and modules to interface with users, sensors, actuators, and/or other modules of a mobile structure. The logic device is adapted to receive docking assist parameters from a user interface for the mobile structure and perimeter sensor data from a perimeter ranging system mounted to the mobile structure. The logic device determines docking assist control signals based, at least in part, on the docking assist parameters and perimeter sensor data, and it then provides the docking assist control signals to a navigation control system for the mobile structure. Control signals may be displayed to a user and/or used to adjust a steering actuator, a propulsion system thrust, and/or other operational systems of the mobile structure.

Abstract: Robotic medical systems may use real-time three-dimensional (3-D) images to convey information to assist a physician or physician assistant. A robotic medical system can include one or more robotic arms. The robotic medical system can include one or more robotic displays. The robotic medical system can be configured to display a 3-D rendering that includes a graphical representation of the one or more robotic arms. The robotic medical system can be configured to update the 3-D rendering in accordance with a pre-programmed workflow corresponding to a procedure, to guide a user through the procedure.

Abstract: Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides systems for targeted delivery of therapeutic agents to Schlemm's canal (SC) endothelial cells. Also provided are methods for using the systems to treat glaucoma or reduce intraocular pressure.

Abstract: Techniques are disclosed for systems and methods to provide graphical user interfaces for assisted and/or autonomous navigation for mobile structures. A navigation assist system includes a user interface for a mobile structure comprising a display and a logic device configured to communicate with the user interface and render a docking user interface on the display. The logic device is configured to monitor control signals for a navigation control system for the mobile structure and render the docking user interface based, at least in part, on the monitored control signals. The docking user interface includes a maneuvering guide with a mobile structure perimeter indicator, an obstruction map, and a translational thrust indicator configured to indicate a translational maneuvering thrust magnitude and direction relative to an orientation of the mobile structure perimeter indicator.