Abstract: A gasket is provided that forms a sealing connection between a pair of tubular members. The gasket comprises a first section shaped to fit within a recess of one of a pair of tubular members. The first section includes an anchor portion comprising first and second sides. The gasket further comprises a second section extending from the first section and is configured to make a sealing contact with the other of the tubular members. The gasket also includes at least one self-locating arm in a sealing contact within the recess and extending from one of the first or second sides of the anchor portion of the first section. The self-locating arm biases the first section such that the other of the first or second sides is in contact with the recess to form a sealing connection.

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract: A gasket is provided that forms a sealing connection between a pair of tubular members. The gasket comprises a first section shaped to fit within a recess of one of a pair of tubular members. The first section includes an anchor portion comprising first and second sides. The gasket further comprises a second section extending from the first section and is configured to make a sealing contact with the other of the tubular members. The gasket also includes at least one self-locating arm in a sealing contact within the recess and extending from one of the first or second sides of the anchor portion of the first section. The self-locating arm biases the first section such that the other of the first or second sides is in contact with the recess to form a sealing connection.

Abstract: A gasket is provided that forms a sealing connection between a pair of tubular members. The gasket comprises a first section shaped to fit within a recess of one of a pair of tubular members. The first section includes an anchor portion comprising first and second sides. The gasket further comprises a second section extending from the first section and is configured to make a sealing contact with the other of the tubular members. The gasket also includes at least one self-locating arm in a sealing contact within the recess and extending from one of the first or second sides of the anchor portion of the first section. The self-locating arm biases the first section such that the other of the first or second sides is in contact with the recess to form a sealing connection.

Abstract: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds.

Abstract: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds.

Abstract: A coupler assembly for use with a pipe or piping sections comprising a unitary annular body, forming first and second cylindrical openings for surrounding a pipe or piping sections to facilitate forming a fluid-tight seal therein. The unitary annular body comprises a medial portion and first and second longitudinal portions integrally connected to opposite ends of the medial portion. Extending from the first and second longitudinal portions away from the medial portion are respective first and second locking arrangements for securing the coupler assembly to a pipe or piping sections.

Abstract: An annular sealing gasket for forming a sealing connection between a first tubular member and a second tubular member. The annular sealing gasket comprises a flexible sealing portion adapted to form a sealing connection between a first tubular member and a second tubular member and a body region adapted for supporting the flexible sealing portion and anchoring the annular sealing gasket to a secured connection. The body region further comprises spaced first and second conical legs extending convergingly away from the body region transversely from the flexible sealing portion.

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract: A method and an annular integral gasket are provided for forming a sealing connection between a first tubular member and a second tubular member. The integral gasket comprises at least one flexible sealing portion adapted to form a sealing connection between a first tubular member and a second tubular member. The integral gasket further comprises a bonding layer adapted to be fixedly attached to a tubular member by a joining process. The integral gasket also comprises a body region adapted for supporting the flexible sealing portion and the bonding layer.

Abstract: A method and apparatus for welding ends of two separate articles or a single article to form a single welded article. The apparatus comprises first and second molds for supporting and clamping first and second ends of at least one article and an infrared heating element for thermally energizing over a prescribed period of time the first and second ends of the at least one article to a welding condition. The apparatus further comprises a regulator for altering the power supplied for energizing the infrared heater over at least a portion of the prescribed period of time to achieve increased electromagnetic radiation penetration into the body of the at least one article beyond the first and second ends. The apparatus also comprises an actuator for advancing the first and second ends into a contacting position to form a single welded article.

Abstract: A method and apparatus for welding two separate ends of an extrusion or two separate extrusion ends to form a flashless extrudate or gasket by having a first and a second mold for supporting and clamping the extrusion ends, and a spacer bar for positioning the extrusion ends to a location within the mold. A heating element elevates the temperature of the extrusion ends to a welding condition, and a clamping device is used for securing the extrusion ends. A flashless welding operation results by inserting and clamping at least one heated extrusion end into a welding mold until an acceptable contact pressure is obtained against the opposing heated extrusion end.

Abstract: A composite high strength annular gasket and method of forming same is used for forming a seal between two pipe members. The gasket comprises a sealing material having a first durometer, the sealing material provides a pliable flexing surface for forming a sealing connection between a mating pipe member and adjoining pipe member during assembly. The gasket also comprises a base material forming one or more cords having a second durometer, the one or more cords embedded in and bonded with the sealing material, providing enhanced anti-compression and tensile strength to the composite annular gasket. The base material has a durometer higher than the sealing material.

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract: A method and an annular integral gasket are provided for forming a sealing connection between a first tubular member and a second tubular member. The integral gasket comprises at least one flexible sealing portion adapted to form a sealing connection between a first tubular member and a second tubular member. The integral gasket further comprises a bonding layer adapted to be fixedly attached to a tubular member by a joining process. The integral gasket also comprises a body region adapted for supporting the flexible sealing portion and the bonding layer.

Abstract: The present invention is directed to an annular gasket for providing a fluid-tight seal between an inner pipe and an outer pipe, when the pipes are in a relative surrounded and surrounding relationship. The gasket includes a gasket portion configured to sealingly engage the inner and outer pipes when the pipes are in a relative surrounded and surrounding relationship. The gasket includes a low coefficient of friction surface which is applied to the gasket portion. The gasket may be formed by a method in which a low coefficient of friction film is inserted into a mold before injection of compounds used to form the gasket.

Abstract: Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.

Abstract: This invention provides methods of identifying an Eg5 binding ligand. The ligand is identified by using the atomic coordinates of an Eg5 crystal to generate a three dimensional structure. The three dimensional structure is used in molecular modeling techniques and docking experiments to identify ligands that bind to the binding pocket of Eg5. A novel binding pocket is identified. The invention also provides a crystallized Eg5 and ligand complex.

Abstract: A coupler assembly (10) and method of manufacture (10) for use with pipe comprising a unitary annular body (20) forming first and second cylindrical openings for surrounding a pipe or piping sections to facilitate forming a fluid-tight seal therein. The unitary annular body (20) comprises a medial portion (64) formed from a first material having a first durometer and first and second lateral portions (56, 58) integrally connected to opposite ends of the medial portion (64). The first and second lateral portions (56, 58) are made from a second material having a second durometer relatively higher than the first durometer of the first material. The coupler assembly (10) further comprises at least one clamping assembly (26) surrounding the unitary annular body member (20) adapted for compressing the coupler assembly (10) into a fluid-tight seal.