Patents by Inventor Mark Ledeboer

Mark Ledeboer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions useful as inhibitors of JAK and other protein kinases
    Patent number: 7312227
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: December 25, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Ledeboer, Brian Ledford
  • Diaminotriazoles useful as inhibitors of protein kinases
    Patent number: 7279469
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: November 17, 2003
    Date of Patent: October 9, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Albert C. Pierce, Michael Amost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Jr., Mark Ledeboer, Shi-Kai Tian, Jinwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, Greg Henkel, Francesco G. Salituro, Jian Wang
  • Inhibitors of JAK protein kinase
    Patent number: 7271179
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: September 18, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Guy W. Bemis, Scott L. Harbeson, Mark Ledeboer
  • Compositions useful as inhibitors of JAK and other protein kinases
    Patent number: 7259161
    Abstract: The present invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: August 21, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Randy S. Bethiel, Mark Ledeboer
  • Pyrrolopyridines useful as inhibitors of protein kinase
    Publication number: 20070135466
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: May 22, 2006
    Publication date: June 14, 2007
    Inventors: Mark Ledeboer, Marion Wannamaker, Luc Farmer, Tiansheng Wang, Albert Pierce, Gabriel Martinez-Botella, Randy Bethiel, Guy Bemis, Jian Wang, Francesco Salituro, Michael Arnost, Jon Come, Jeremy Green, Michelle Stewart, Craig Marhefka
  • Compositions useful as inhibitors of protein kinases
    Patent number: 7226919
    Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3, JAK-3, FLT-3, PIM-1, SYK, or PDK-1 mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: June 5, 2007
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Mark Ledeboer, Robert Davies, David Messersmith, Young-Choon Moon, Michael Mullican
  • Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
    Patent number: 7169798
    Abstract: The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: January 30, 2007
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Pyrrolopyrimidines useful as inhibitors of protein kinase
    Publication number: 20070004762
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: February 2, 2006
    Publication date: January 4, 2007
    Inventors: Mark Ledeboer, Albert Pierce, Guy Bemis, Luc Farmer, Tiansheng Wang, David Messersmith, John Duffy, Francesco Salituro, Jian Wang
  • Pyrrolopyrimidines useful as inhibitors of protein kinase
    Publication number: 20060183761
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: February 1, 2006
    Publication date: August 17, 2006
    Inventors: Mark Ledeboer, Albert Pierce, Guy Bemis, Luc Farmer, Tiansheng Wang, David Messersmith, John Duffy, Francesco Salituro, Jian Wang
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 7084159
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: August 1, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Diaminotriazole compounds useful as protein kinase inhibitors
    Publication number: 20060063756
    Abstract: The present invention relates to inhibitors of protein kinases, particularly to inhibitors of JAK2 and JAK3. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: September 19, 2005
    Publication date: March 23, 2006
    Inventors: Francesco Salituro, Mark Ledeboer, Brian Ledford, Jian Wang, Albert Pierce, John Duffy, David Messersmith
  • Protein kinase inhibitors and uses thereof
    Publication number: 20050228005
    Abstract: Described herein are benzisoxazole compounds of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N—O or O—N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Application
    Filed: November 29, 2004
    Publication date: October 13, 2005
    Inventors: Young Moon, Jeremy Green, Robert Davies, Deb Choquette, Albert Pierce, Mark Ledeboer
  • Inhibitors of Src and Lck protein kinases
    Publication number: 20050049246
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A-B is N—O or O—N and G, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: December 4, 2003
    Publication date: March 3, 2005
    Inventors: Guy Bemis, Huai Gao, Edmund Harrington, Francesco Salituro, Jian Wang, Mark Ledeboer
  • Inhibitors of c-jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20050026967
    Abstract: The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: February 13, 2004
    Publication date: February 3, 2005
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Protein kinase inhibitors and uses thereof
    Patent number: 6825190
    Abstract: Described herein are benzisoxazole compounds of formula I: or a pharmaceutically acceptable derivative or prodrug thereof, wherein A-B is N—O or O—N; Ar is an optionally substituted C5-10 aryl group; R1 is hydrogen or an optionally substituted group selected from C1-10 aliphatic, C5-10 aryl, C6-12 aralkyl, C3-10 heterocyclyl, or C4-12 heterocyclylalkyl; and T, n, R2 and R3 are as described in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK-3 and JAK mammalian protein kinases. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: November 30, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Young-Choon Moon, Jeremy Green, Robert Davies, Deborah Choquette, Albert Pierce, Mark Ledeboer
  • Diaminotriazoles useful as inhibitors of protein kinases
    Publication number: 20040214817
    Abstract: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: November 17, 2003
    Publication date: October 28, 2004
    Inventors: Albert C. Pierce, Michael Amost, Robert J. Davies, Cornelia J. Forster, Vincent Galullo, Ronald Grey, Mark Ledeboer, Shi-Kai Tian, Jinwang Xu, Hayley Binch, Brian Ledford, David Messersmith, Suganthi Nanthakumar, Andrew Jayaraj, Greg Henkel, Francesco G. Salituro, Jian Wang
  • Compositions useful as inhibitors of protein kinases
    Publication number: 20040186115
    Abstract: The present invention provides a compound of formula (I): 1
    Type: Application
    Filed: December 17, 2003
    Publication date: September 23, 2004
    Inventors: Mark Ledeboer, Robert J. Davies, David Messersmith, Young-Choon Moon, Michael D. Mullican
  • Compositions useful as inhibitors of JAK and other protein kinases
    Publication number: 20040147507
    Abstract: The present invention provides a compound of formula I: 1
    Type: Application
    Filed: November 3, 2003
    Publication date: July 29, 2004
    Inventors: Mark Ledeboer, Brian Ledford
  • Isoxazoles and uses thereof
    Publication number: 20040132755
    Abstract: The present invention provides a compound of formula I: 1
    Type: Application
    Filed: September 8, 2003
    Publication date: July 8, 2004
    Inventors: Mark Ledeboer, Brian Ledford, Francesco G. Salituro
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20040097531
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: July 9, 2003
    Publication date: May 20, 2004
    Inventors: Mark Ledeboer, Jian Wang, Young Choon Moon