Patents by Inventor Mark Ledeboer

Mark Ledeboer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of Jak protein kinase
    Publication number: 20040038992
    Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
    Type: Application
    Filed: May 6, 2003
    Publication date: February 26, 2004
    Inventors: Guy W. Bemis, Scott L. Harbeson, Mark Ledeboer
  • Inhibitors of c-JUN N terminal kinases (JNK) and other protein kinases
    Patent number: 6693108
    Abstract: The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)—R, or T(n)—Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: February 17, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Inhibitors of Src and Lck protein kinases
    Patent number: 6689778
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative thereof, wherein A—B is N—O or O—N and G, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 10, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Guy Bemis, Huai Gao, Edmund Harrington, Francesco Salituro, Jian Wang, Mark Ledeboer
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20040023963
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: May 14, 2003
    Publication date: February 5, 2004
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Protein kinase inhibitors and uses thereof
    Publication number: 20040009996
    Abstract: Described herein are benzisoxazole compounds of formula I: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: January 15, 2004
    Inventors: Young-Choon Moon, Jeremy Green, Robert Davies, Deborah Choquette, Albert Pierce, Mark Ledeboer
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 6642227
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: November 4, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Inhibitors of Src and Lck protein kinases
    Publication number: 20030171389
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: September 11, 2003
    Inventors: Guy Bemis, Huai Gao, Edmund Harrington, Francesco Salituro, Jian Wang, Mark Ledeboer
  • Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20030149051
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: February 12, 2002
    Publication date: August 7, 2003
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20030096816
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: April 10, 2002
    Publication date: May 22, 2003
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20020111353
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: December 5, 2001
    Publication date: August 15, 2002
    Inventors: Mark Ledeboer, Francesco Salituro, Young-Choon Moon