Abstract: A device for treating spinal tissue of a patient's body may include an energy source and first and second probe assemblies. Each of the probe assemblies may have an electrically conductive energy delivery device electrically coupled to the energy source, and may also have an electrothermal device for cooling the probe assembly. The device is configured so that the energy source delivers energy to the spinal tissue through the energy delivery devices in a bipolar mode that concentrates delivered energy between the energy delivery devices to create a lesion within the spinal tissue while the electrothermal devices cool the probe assemblies. Related methods of use include cooling, at times via an electrothermal device.

Abstract: Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation.

Abstract: Methods and percutaneous devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via percutaneous carotid body ablation.

Abstract: A method of treating spinal tissue of a patient's body is disclosed, the method using a system comprising an energy source and first and second internally-cooled probe assemblies, wherein each of the probe assemblies comprises an electrically conductive energy delivery device electrically coupled to the energy source. The method comprises: inserting the energy delivery devices of the first and second internally-cooled probe assemblies into spaced-apart treatment sites for the spinal tissue; delivering energy from the energy source to the spinal tissue through the energy delivery devices to create a lesion within the spinal tissue; delivering a cooling fluid to the energy delivery devices; and controlling the delivery of energy and the delivery of the cooling fluid to the energy delivery devices such that the lesion extends between the energy delivery devices.

Abstract: The invention comprises a method for introduction of materials into a patient's body. The method generally comprises providing an elongate member for introducing the material. The elongate member defines a lumen and comprises a distal end defining an aperture and a proximal end. The method further comprises the steps of positioning the elongate member at a target site of a patient's body; providing a motorized device at least partially disposed within the lumen; and introducing the material through the lumen into the target site using the motorized device.

Abstract: The invention comprises a method for introduction of materials into a patient's body. The method generally comprises providing an elongate member for introducing the material. The elongate member defines a lumen and comprises a distal end defining an aperture and a proximal end. The method further comprises the steps of positioning the elongate member at a target site of a patient's body; providing a motorized device at least partially disposed within the lumen; and introducing the material through the lumen into the target site using the motorized device.

Abstract: The invention comprises a method for introduction of materials into a patient's body. The method generally comprises providing an elongate member for introducing the material. The elongate member defines a lumen and comprises a distal end defining an aperture and a proximal end. The method further comprises the steps of positioning the elongate member at a target site of a patient's body; providing a motorized device at least partially disposed within the lumen; and introducing the material through the lumen into the target site using the motorized device.

Abstract: Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Abstract: The invention comprises a method for removal of bone marrow tissue from a patient's body. The method generally comprises the steps of providing an apparatus comprising an elongate member for receiving bone marrow tissue. The elongate member defines a lumen and comprises a distal end defining an aperture and a proximal end. The apparatus further comprises an elongate tissue removal member for conveying bone marrow tissue through the lumen. The tissue removal member is rotatably disposed within the lumen. The method further comprises gathering a sample of said tissue into said lumen; and conveying with said tissue removal member at least a portion of the tissue sample proximally along said lumen. The step of gathering may be accomplished by advancing the apparatus through the tissue.

Abstract: A treatment method is disclosed for treating a bodily tissue utilizing one or more steps of removal of material as well as one or more steps of energy delivery in order to effectively treat the bodily tissue. These mechanisms of treatment may beneficially be used to induce separate treatment effects, for example to treat both the symptoms and the underlying cause of a specific pathological condition. In addition, a specific application of the inventive method is described for using the inventive method to treat an intervertebral disc.

Abstract: Methods of treating the sacroiliac region of a patient's body by delivering energy are described. In some embodiments, the method comprises the steps of: inserting at least one probe into the sacroiliac region, the probe comprising at least one energy delivery device: positioning the at least one energy delivery device adjacent material to be treated; and delivering energy through the at least one energy delivery device to create a longitudinal strip lesion; wherein the at least one energy delivery device remains in a substantially static position during creation of the strip lesion. In some embodiments, energy may be delivered to treat at least two branches of the sacral nerves or to create an intra-articular lesion.

Abstract: Methods of treating the sacroiliac region of a patient's body by delivering energy are described. In some embodiments, the method comprises the steps of: positioning one elongated probe comprising at least one energy delivery device within a sacroiliac joint of the body; and delivering radiofrequency energy through the elongated probe. In some embodiments, the delivery of energy results in the creation of a lesion. In further embodiments, energy may be delivered substantially along a long axis of the sacroiliac joint. In yet further embodiments, at least one energy delivery device may be positioned adjacent a sacroiliac joint and energy may be delivered so as to create a lesion at least partially within the joint.

Abstract: Methods of treating the sacroiliac region of a patient's body by delivering energy are described. In some embodiments, the method comprises the steps of: inserting at least one probe into the sacroiliac region, the probe comprising at least one energy delivery device; positioning the at least one energy delivery device adjacent material to be treated; and delivering energy through the at least one energy delivery device to create a longitudinal strip lesion; wherein the at least one energy delivery device remains in a substantially static position during creation of the strip lesion. In some embodiments, energy may be delivered to treat at least two branches of the sacral nerves or to create an intra-articular lesion.

Abstract: An electrosurgical apparatus comprising an energy source operable to concurrently provide a first signal and a second signal, said first and second signals having different frequencies; and a signal processor operable to receive a third signal from a patient's body, to process said third signal, and to produce an output based on a processing of said third signal; wherein said third signal is an evoked potential generated by said patient's body in response to a delivery of said second signal to said patient's body.

Abstract: A method of treating spinal tissue of a patient's body is disclosed, the method using a system comprising an energy source and first and second internally-cooled probe assemblies, wherein each of the probe assemblies comprises an electrically conductive energy delivery device electrically coupled to the energy source. The method comprises: inserting the energy delivery devices of the first and second internally-cooled probe assemblies into spaced-apart treatment sites for the spinal tissue; delivering energy from the energy source to the spinal tissue through the energy delivery devices to create a lesion within the spinal tissue; delivering a cooling fluid to the energy delivery devices; and controlling the delivery of energy and the delivery of the cooling fluid to the energy delivery devices such that the lesion extends between the energy delivery devices.

Abstract: A medical probe assembly, system, and methods for the use thereof to treat tissue are described. The system optionally comprises an energy source, two internally-cooled probe assemblies, and one or more cooling devices to provide cooling to at least one of the probe assemblies. The probe assemblies may be configured in a bipolar mode, whereby current flows preferentially between the probe assemblies. The probe assemblies and system described herein are particularly useful to deliver radio frequency energy to a patient's body. RF energy delivery may be used for various applications, including the treatment of pain, tumor ablation and cardiac ablation.

Abstract: Methods of treating the sacroiliac region of a patient's body by delivering energy are described. In some embodiments, the method comprises the steps of: positioning one elongated probe comprising at least one energy delivery device within a sacroiliac joint of the body; and delivering radiofrequency energy through the elongated probe. In some embodiments, the delivery of energy results in the creation of a lesion. In further embodiments, energy may be delivered substantially along a long axis of the sacroiliac joint. In yet further embodiments, at least one energy delivery device may be positioned adjacent a sacroiliac joint and energy may be delivered so as to create a lesion at least partially within the joint.

Abstract: An electrosurgical device comprising a means for impeding flow for delivering energy to a region of tissue is described. In addition, a method of treating the sacroiliac region of a patient's body by delivering energy is also described. The method includes the steps of inserting a probe into a target site within the sacroiliac region of a patient's body and delivering energy to the probe to treat tissue within the target site.

Abstract: A method and apparatus are disclosed for removal of material from a body. The apparatus comprises an elongate member defining a lumen and comprising a proximal end and a distal end. The distal end of the elongate member defines an aperture. The apparatus further comprises a tissue removal member. The tissue removal member comprises a shaft rotatably disposed within the lumen of the elongate member. The apparatus further comprises a rigid cannula for inserting the elongate member into a patient's body. The cannula defines a lumen for receiving the elongate member, and has a proximal open end and a distal open end communicating with the lumen of the cannula.

Abstract: The invention comprises a method for introduction of materials into a patient's body. The method generally comprises providing an elongate member for introducing the material. The elongate member definines a lumen and comprises a distal end defining an aperture and a proximal end. The method further comprises the steps of positioning the elongate member at a target site of a patient's body; providing a motorized device at least partially disposed within the lumen; and introducing the material through the lumen into the target site using the motorized device.