Abstract: The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. In certain embodiments, the immune effector is an immune effector protein or an immune effector fragment thereof. The current invention also pertains to a method of treating a disease in a subject, the method comprising administering to the subject a pharmaceutically effective amount of the molecular conjugates of the current invention to the subject. The methods of the current invention can be used to treat cancer, such as breast cancer, ovarian cancer, prostate cancer, lung cancer, pancreatic cancer, or melanoma.

Abstract: The current invention pertains to stabilized peptoids or peptoid-peptide hybrids. The peptoids or peptoid-peptide hybrids are stabilized by side chain-side to side chain linkages and/or backbone cyclization. The current invention also provides a positional library scanning method for identification of peptoids or peptoid-peptide hybrids having a desired biological activity.

Abstract: A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of:

Abstract: Communicating location information for a first user of a first communication client from a first user terminal over a communications system to a second user terminal is described. A second communication client executed by the second user terminal displays a list of contacts associated with a second user of the second communication client that comprises a first contact representing the first user. The first user terminal determines a location of the first user and stores the determined location in a store of the first user terminal. The first communication client reads the stored location from the store. The first communication client further generates a message comprising a visual indication of the location read from the store and transmits the message to the second user terminal. The visual indication of the location is displayed on the second user terminal in the contact list in association with the first contact.

Abstract: Disclosed are compositions and methods for ex vivo expansion of tumorinfiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumorinfiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes expanded by the disclosed methods.

Abstract: A method of communicating location information relating to a first user of a first communication client from a first user terminal over a communications system to a second user terminal, the first user terminal executing the first communication client and the second user terminal executing a second communication client, the method comprising: the second communication client displaying a list of contacts associated with a second user of the second communication client, the list of contacts comprising a first contact representing the first user; the first user terminal determining a location of the first user; the first user terminal storing the determined location in a store of the first user terminal; the first communication client reading the stored location from the store; the first communication client generating a message comprising a visual indication of the location read from the store; transmitting the message from the first user terminal to the second user terminal; and displaying the visual indicatio

Abstract: A user terminal comprising: a positioning system arranged to detect a geographical location of the user terminal; a transceiver for communicating with other user terminals via a communication network; and a communication processing apparatus coupled to the transceiver and positioning system. The communication processing apparatus is arranged to detect communication events occurring via the transceiver and communication network in relation to other user terminals, and to maintain a log of the communication events. Further, the communication processing apparatus is configured to organize the log in dependence on a geographical location detected by the positioning system.

Abstract: A method and system for simulation of deformation of elastic materials are disclosed herein. A matrix-free geometric multigrid method utilizing a direct coarse grid discretization is presented for the solution of linear systems resulting from an octree discretization of the equations of corotational linear elasticity. The diagonal component of the stiffness matrix needed for the multigrid smoother is calculated without generating the stiffness matrix. The use of an incomplete linear octree data structure supports the efficient simulation of objects with complicated boundaries. Furthermore, the method is robust to large deformations, making it suitable for character skinning applications in computer animation.

Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

Abstract: The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound adduct, a method for treating disorders such as proliferation disorders (e.g., malignancies), bone deficiency diseases, and autoimmune diseases, and a method for suppressing the growth of, or inducing apoptosis in, cells (e.g., malignant cells).

Abstract: Embodiments include a television appliance configured to display a selected on-screen viewing activity, and a client application. The client application is configured to maintain a list of contacts and allow a user of the media appliance to establish communication events with contacts via a network interface and packet-based network. The client application is further configured to receive a machine-readable data item via the network interface and packet-based network from a television appliance of one or more of said contacts, the machine-readable data item indicating a current television channel being viewed by the respective contact. In at least some embodiments, the client application may control operation of said user's television appliance in relation to the contact's television appliance based on the data item.

Abstract: Techniques for displaying graphical representations of contacts are described. In accordance with one or more embodiments, a group of graphical representations of contacts is displayed at a first size in a display region. In response to a selection of a subgroup of the graphical representations, the subgroup of graphical representations is automatically resized to fit in the display region at a second size.

Abstract: A method of establishing a communication event between a first user and a second user of a communication system; wherein the first user operates a user terminal executing an electronic game application; the method comprising the steps of: storing contact information for at least the second user of the communication system; associating the contact information of the second contact with one or more game objects in the electronic game application; receiving an input signal from the first user to interact with a game object displayed during execution of the electronic game application; and responsive to receiving the signal to interact with the game object, establishing a communication event between the first user of the game application and the second user of the communication system using the contact information associated with the game object.

Abstract: The invention concerns peptoid-peptide hybrids that may act as protein interaction inhibitors (PPIIs). Another aspect of the invention concerns a method for treating a disorder (e.g., an oncologic disorder) in a human or animal subject, comprising administering an effective amount of a peptoid-peptide hybrid (a peptoid body) of the invention, or a composition comprising a peptoid-peptide hybrid, to the subject in need thereof. Another aspect of the subject invention concerns a method for killing or inhibiting the growth of cells (e.g., cancer cells or malaria-infected cells), comprising contacting a cancer cell in vitro or in vivo with an effective amount of a peptoid-peptide hybrid, or a composition comprising the peptoid-peptide hybrid. Another aspect of the invention concerns a method for producing a peptoid-peptide hybrid.

Abstract: The invention relates to novel cyclic compounds (cyclic peptides), linkers useful as beta-turn promoters in cyclic peptides, and methods for treatment of malignant cells in vitro or in vivo using one or more linear and cyclic peptides. The peptides can act as integrin interaction inhibitors and may be used in the treatment of cancers as monotherapies or in combination with other anti-cancer agents, such as proteasome inhibitors, inhibitors of autophagy, alkylating agents, MEK inhibitors, FAK/PYK2 inhibitors, and EGFR inhibitors. The invention further concerns a method of predicting the binding of a cyclic or linear HYD1 peptide to a cancer cell by assessing overexpression of biomarkers such as CD44, VLA-4 integrin, basigin, CD138 (syndecan 1), NCAM, ICAM1, ICAM3, and CD59.

Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

Abstract: The present invention concerns the use of HYD1 peptides to reduce activated T-cell numbers and/or to promote bone preservation in vivo. The present invention concerns methods of treating a bone deficiency and/or an autoimmune disorder, comprising administering an effective amount of a HYD1 peptide. Another aspect of the invention concerns a pharmaceutical composition comprising a HYD1 peptide and another agent for treating a bone deficiency and/or another agent for treating an autoimmune disorder.

Abstract: Embodiments include a television appliance configured to display a selected on-screen viewing activity, and a client application. The client application is configured to maintain a list of contacts and allow a user of the media appliance to establish communication events with contacts via a network interface and packet-based network. The client application is further configured to receive a machine-readable data item via the network interface and packet-based network from a television appliance of one or more of said contacts, the machine-readable data item indicating a current television channel being viewed by the respective contact. In at least some embodiments, the client application may control operation of said user's television appliance in relation to the contact's television appliance based on the data item.

Abstract: Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interact with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etoposide.

Abstract: A method of transmitting video data comprising: establishing a bidirectional video channel between a first terminal and a second terminal in a packet-based communication network; beginning a live, face-to-face video call over the established channel by generating first video data from a video camera of the first terminal, transmitting the first video data to the second terminal for display on a screen of the second terminal, receiving second video data generated from a video camera of the second terminal, and displaying the second video data on a screen of the first terminal; generating third video data at the first terminal from a source other than the video camera of the first terminal; receiving a user selection at the first terminal; and in response to the user selection, transmitting the third video data to the second user over the established channel of the packet-based communication network.